Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

2006 • 4,019 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Regulatory T Cells: Mechanisms of Differentiation and Function

2007 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

FOXP3+ regulatory T cells in the human immune system

2010 • 2,283 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

2009 • 2,107 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Combining immunotherapy and targeted therapies in cancer treatment

2012 • 1,430 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

2006 • 1,180 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

2010 • 1,163 citations

miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection

2007 • 1,147 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

2011 • 1,039 citations

Humanized mice in translational biomedical research

2007 • 1,036 citations

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

2011 • 1,023 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

MicroRNA Control in the Immune System: Basic Principles

2009 • 1,002 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Inside Out

2003 • 974 citations

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

2010 • 960 citations

Smad regulation in TGF-β signal transduction

2001 • 917 citations

Rapamycin passes the torch: a new generation of mTOR inhibitors

2011 • 914 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

2009 • 882 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

Dissolving polymer microneedle patches for influenza vaccination

2010 • 813 citations

TGF-β: A Master of All T Cell Trades

2008 • 805 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus

2002 • 803 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

2009 • 763 citations

Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

2010 • 760 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Toll-Like Receptor 8-Mediated Reversal of CD4 ⁺ Regulatory T Cell Function

2005 • 734 citations

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

2004 • 730 citations

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

2007 • 730 citations

DNA methylation controls Foxp3 gene expression

2008 • 729 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation

2002 • 713 citations

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

2009 • 712 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

2011 • 705 citations

“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

2008 • 688 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

Genes and Antibodies

1959 • 675 citations

Stability of the Regulatory T Cell Lineage in Vivo

2010 • 675 citations

Oral Immunotherapy for Treatment of Egg Allergy in Children

2012 • 644 citations

The secret ally: immunostimulation by anticancer drugs

2012 • 642 citations

Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes

2005 • 630 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

2012 • 574 citations

Nonredundant roles for Stat5a/b in directly regulating Foxp3

2007 • 561 citations

Checkpoint Blockade in Cancer Immunotherapy

2006 • 558 citations

Control of Regulatory T Cell Lineage Commitment and Maintenance

2009 • 557 citations

The anticancer immune response: indispensable for therapeutic success?

2008 • 556 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

A role for Dicer in immune regulation

2006 • 514 citations

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer

2005 • 504 citations

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

2009 • 493 citations

Regulatory Lymphocytes and Intestinal Inflammation

2009 • 489 citations

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

2009 • 482 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation

2006 • 475 citations

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

2010 • 470 citations

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

2007 • 468 citations

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

2010 • 443 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Mechanisms for T cell receptor triggering

2010 • 437 citations

Persistent Toll-like receptor signals are required for reversal of regulatory T cell–mediated CD8 tolerance

2004 • 433 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

2006 • 400 citations

Cancer immunotherapy – revisited

2011 • 399 citations

Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

2001 • 386 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

Dicer-dependent microRNA pathway safeguards regulatory T cell function

2008 • 381 citations

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

2008 • 367 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

2008 • 358 citations

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

2009 • 353 citations

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

2006 • 342 citations

Loss of FOXP3 expression in natural human CD4⁺CD25⁺ regulatory T cells upon repetitive in vitro stimulation

2009 • 332 citations

Prediction and Pathogenesis in Type 1 Diabetes

2010 • 328 citations

Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses

2009 • 328 citations

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

2009 • 324 citations

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

2009 • 315 citations

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

2010 • 296 citations

Control of Autoimmunity by Naturally Arising Regulatory CD4+ T Cells

2003 • 292 citations

Clinical Use of Anti‐CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

2009 • 281 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

2005 • 278 citations

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1999 • 276 citations

Use of Inhaled Insulin in a Basal/Bolus Insulin Regimen in Type 1 Diabetic Subjects

2005 • 274 citations

Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor

2006 • 267 citations

Sphingosine 1-Phosphate Analogs as Receptor Antagonists

2004 • 267 citations

Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

2007 • 267 citations

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

2010 • 266 citations

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

2005 • 263 citations

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

2010 • 261 citations

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

2009 • 257 citations

A Structural Framework for Deciphering the Link Between I-A ^g7 and Autoimmune Diabetes

2000 • 256 citations

Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor

2005 • 249 citations

Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells

2002 • 246 citations

The Clonal-Selection Theory

1987 • 244 citations

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

2005 • 235 citations

Isoform-Specific Inhibition of RORα-Mediated Transcriptional Activation by Human FOXP3

2008 • 229 citations

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

2010 • 228 citations

Defective suppression of Th2 cytokines by CD4⁺CD25⁺ regulatory T cells in birch allergics during birch pollen season

2004 • 219 citations

Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production

2003 • 211 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges

2007 • 207 citations

Human CD25+ Regulatory T Cells Maintain Immune Tolerance to Nickel in Healthy, Nonallergic Individuals

2003 • 204 citations

FOXP3 acts as a rheostat of the immune response

2005 • 201 citations

Structural Basis of Peptide Binding and Presentation by the Type I Diabetes-Associated MHC Class II Molecule of NOD Mice

2000 • 197 citations

A Decrease of Regulatory T Cells Correlates With Overall Survival After Sunitinib-based Antiangiogenic Therapy in Metastatic Renal Cancer Patients

2010 • 196 citations

Diabetogenic T cells recognize insulin bound to IA^g7in an unexpected, weakly binding register

2010 • 189 citations

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1993 • 182 citations

IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

2007 • 180 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Pancreatic β-Cell Function and Immune Responses to Insulin After Administration of Intranasal Insulin to Humans At Risk for Type 1 Diabetes

2004 • 177 citations

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

2009 • 159 citations

FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells

2007 • 158 citations

Imatinib Mesylate Inhibits CD4+CD25+ Regulatory T Cell Activity and Enhances Active Immunotherapy against BCR-ABL− Tumors

2008 • 153 citations

Cutting Edge: TCR Stimulation Is Sufficient for Induction of Foxp3 Expression in the Absence of DNA Methyltransferase 1

2009 • 153 citations

The cunning little vixen: Foxo and the cycle of life and death

2009 • 150 citations

Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995.

2011 • 149 citations

Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

2005 • 149 citations

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut

2012 • 147 citations

Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity

2007 • 144 citations

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor

2011 • 141 citations

Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-β Sensitivity In Vitro and In Vivo

2006 • 138 citations

Specificity and detection of insulin-reactive CD4⁺T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

2011 • 137 citations

The Sphingosine 1-Phosphate Receptor Agonist FTY720 Differentially Affects the Sequestration of CD4+/CD25+ T-Regulatory Cells and Enhances Their Functional Activity

2005 • 137 citations

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

2010 • 136 citations

Immunotherapy of Type 1 Diabetes: Where Are We and Where Should We Be Going?

2010 • 136 citations

Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

2011 • 133 citations

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

2004 • 133 citations

Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer

2012 • 133 citations

STAT3: A Target to Enhance Antitumor Immune Response

2010 • 125 citations

KRP-203, a Novel Synthetic Immunosuppressant, Prolongs Graft Survival and Attenuates Chronic Rejection in Rat Skin and Heart Allografts

2005 • 119 citations

A Model for Developmentally Acquired Thymus‐Dependent Tolerance to Central and Peripheral Antigens

1996 • 116 citations

Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21

2008 • 116 citations

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3

2008 • 114 citations

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

1995 • 109 citations

Rapid Pharmacokinetics of Intradermal Insulin Administered Using Microneedles in Type 1 Diabetes Subjects

2011 • 107 citations

Priming and effector dependence on insulin B:9–23 peptide in NOD islet autoimmunity

2007 • 103 citations

Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4⁺CD25^– cells

2008 • 98 citations

Human regulatory T cells in autoimmune diseases

2010 • 88 citations

Enhancement of antigen-specific Treg vaccination in vivo

2010 • 84 citations

Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression

2008 • 83 citations

Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases

2009 • 79 citations

Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents

2010 • 76 citations

T cell receptor recognition of self and foreign antigens in the induction of autoimmunity

2011 • 72 citations

CD4⁺Foxp3⁺ Regulatory T‐cell Impairment by Paclitaxel is Independent of Toll‐like Receptor 4

2011 • 68 citations

Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

2011 • 59 citations

High diversity of the immune repertoire in humanized NOD.SCID.γc^−/− mice

2009 • 58 citations

Clonal Selection Theory

1960 • 31 citations

RAD 001 (everolimus) prevents mTOR and Akt late re‐activation in response to imatinib in chronic myeloid leukemia

2009 • 25 citations

Antigen-Specific Induction of Regulatory T Cells In Vivo and In Vitro

2011 • 23 citations

Identification of CML-modified Proteins in Hemofiltrate of Diabetic Patients by Proteome Analysis

2007 • 8 citations

Mucosal Insulin Vaccination for Type 1 Diabetes Prevention

2008 • 6 citations

Cited By (0)

No citing papers found in database