Diabetogenic T cells recognize insulin bound to IA^g7in an unexpected, weakly binding register

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk

2008 • 709 citations

Aire

2009 • 533 citations

Peptide ‘Velcro’: Design of a heterodimeric coiled coil

1993 • 437 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

2001 • 386 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Chromogranin A is an autoantigen in type 1 diabetes

2010 • 330 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Three Recessive Loci Required for Insulin-Dependent Diabetes in Nonobese Diabetic Mice

1987 • 293 citations

A Structural Framework for Deciphering the Link Between I-A ^g7 and Autoimmune Diabetes

2000 • 256 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

Structural Basis of Peptide Binding and Presentation by the Type I Diabetes-Associated MHC Class II Molecule of NOD Mice

2000 • 197 citations

Insulin as an autoantigen in NOD/human diabetes

2008 • 193 citations

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule

2005 • 181 citations

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

2010 • 174 citations

Post-translational modifications of self antigens: implications for autoimmunity

2004 • 166 citations

Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity

2005 • 140 citations

The I-Ag7 MHC Class II Molecule Linked to Murine Diabetes Is a Promiscuous Peptide Binder

2000 • 134 citations

Binding interactions between peptides and proteins of the class II Major Histocompatibility Complex

2002 • 110 citations

Structural and Functional Consequences of Altering a Peptide MHC Anchor Residue

2001 • 108 citations

The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-Binding Segment in More Than One Form

2007 • 100 citations

Structural Snapshot of Aberrant Antigen Presentation Linked to Autoimmunity

2002 • 98 citations

Antigen-specific. I region-restricted interactions in vitro between tumor cell lines and T cell hybridomas.

1982 • 96 citations

On the Pathogenicity of Autoantigen-Specific T-Cell Receptors

2008 • 95 citations

Self peptides isolated from MHC glycoproteins of non-obese diabetic mice.

1994 • 92 citations

T Cells Distinguish MHC-Peptide Complexes Formed in Separate Vesicles and Edited by H2-DM

2004 • 88 citations

In APCs, the Autologous Peptides Selected by the Diabetogenic I-Ag7 Molecule Are Unique and Determined by the Amino Acid Changes in the P9 Pocket

2002 • 76 citations

Mimotopes for Alloreactive and Conventional T Cells in a Peptide–MHC Display Library

2004 • 74 citations

Use of baculovirus MHC/peptide display libraries to characterize T‐cell receptor ligands

2006 • 73 citations

Dual Overlapping Peptides Recognized by Insulin Peptide B:9–23 T Cell Receptor AV13S3 T Cell Clones of the NOD Mouse

2000 • 63 citations

Disulfide Bond Engineering to Trap Peptides in the MHC Class I Binding Groove

2007 • 59 citations

New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

2009 • 56 citations

Peptide register shifting within the MHC groove: theory becomes reality

2003 • 51 citations