Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

2006 • 1,535 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Immunoregulatory functions of mTOR inhibition

2009 • 808 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients

2006 • 693 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

2005 • 583 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

2009 • 411 citations

Rapamycin and mTOR kinase inhibitors

2008 • 401 citations

Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease

2007 • 388 citations

Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

2007 • 383 citations

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

2005 • 371 citations

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

2007 • 335 citations

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25+ Regulatory T Cells

2004 • 279 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen-Specific Regulatory T Cells

2007 • 258 citations

Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

2003 • 255 citations

T‐cell costimulatory pathways in allograft rejection and tolerance

2003 • 218 citations

Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft-versus-host disease

2002 • 197 citations

Regulatory T cells in transplantation

2002 • 189 citations

The Pim kinases control rapamycin-resistant T cell survival and activation

2005 • 182 citations

Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

2008 • 180 citations

Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft-versus-host disease

2002 • 172 citations

Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+CD25+FoxP3+ T cells

2007 • 161 citations

Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells

2006 • 153 citations

Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.

1990 • 149 citations

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4+CD25+FOXP3+ Regulatory T-Cells

2008 • 134 citations

CTLA-4 up-regulation plays a role in tolerance mediated by CD45

2001 • 113 citations

The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice

2007 • 112 citations

CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis

2008 • 109 citations

Interleukin-7-Dependent Expansion and Persistence of Melanoma-Specific T Cells in Lymphodepleted Mice Lead to Tumor Regression and Editing

2005 • 84 citations

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.

1995 • 80 citations

Requirements for induction and maintenance of peripheral tolerance in stringent allograft models

2005 • 36 citations

Reprogramming the immune system: co‐receptor blockade as a paradigm for harnessing tolerance mechanisms

2008 • 36 citations

Donor reactive regulatory T cells

2009 • 31 citations

Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo

2006 • 28 citations

T cell dependence on mTOR signaling

2009 • 22 citations

Regulatory T cells - a journey from rodents to the clinic

2007 • 11 citations