The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Defining the Role of mTOR in Cancer

2007 • 2,755 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

mTOR signaling at a glance

2009 • 2,005 citations

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

2009 • 1,887 citations

mTOR regulates memory CD8 T-cell differentiation

2009 • 1,473 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

2009 • 1,172 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

2008 • 876 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

2007 • 661 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

2010 • 604 citations

Rheb fills a GAP between TSC and TOR

2003 • 467 citations

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

2010 • 442 citations

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells

2001 • 437 citations

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

2008 • 383 citations

Identification of S6 Kinase 1 as a Novel Mammalian Target of Rapamycin (mTOR)-phosphorylating Kinase

2005 • 356 citations

KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium

2006 • 343 citations

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

2009 • 315 citations

rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.

1994 • 294 citations

Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment

2005 • 271 citations

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

2009 • 262 citations

Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

2007 • 254 citations

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

2002 • 212 citations

Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity

2007 • 207 citations

Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells

2006 • 189 citations

Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin

2006 • 128 citations

SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunit

2003 • 122 citations

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

2008 • 119 citations

The Apical Complex Couples Cell Fate and Cell Survival to Cerebral Cortical Development

2010 • 110 citations

Suppressor of Cytokine Signaling 3 Regulates Proliferation and Activation of T-helper Cells

2003 • 110 citations

mTOR: taking cues from the immune microenvironment

2009 • 108 citations

Nogo-66 Promotes the Differentiation of Neural Progenitors into Astroglial Lineage Cells through mTOR-STAT3 Pathway

2008 • 106 citations

The Control of Allergic Conjunctivitis by Suppressor of Cytokine Signaling (SOCS)3 and SOCS5 in a Murine Model

2005 • 105 citations

What determines Th2 differentiation, in vitro and in vivo?

2010 • 99 citations

IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis

2005 • 96 citations

Rheb Interacts with Raf-1 Kinase and May Function To Integrate Growth Factor- and Protein Kinase A-Dependent Signals

1997 • 87 citations

Interferon-γ engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein

2004 • 85 citations

The mTORC2 Complex Regulates Terminal Differentiation of C2C12 Myoblasts

2009 • 65 citations

Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas

2008 • 38 citations

Inhibition of Mammalian Target of Rapamycin Signaling by 2-(Morpholin-1-yl)pyrimido[2,1-α]isoquinolin-4-one

2007 • 31 citations

Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation

2009 • 29 citations

Sequence Motifs in IL-4Rα Mediating Cell-Cycle Progression of Primary Lymphocytes

2005 • 24 citations