Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

2003 • 1,228 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

2002 • 1,189 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes

2005 • 1,080 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Partners in transcription: NFAT and AP-1

2001 • 757 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

2005 • 666 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

The many important facets of T-cell repertoire diversity

2004 • 640 citations

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice.

1994 • 640 citations

Effects of Oral Insulin in Relatives of Patients With Type 1 Diabetes

2005 • 630 citations

TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

2003 • 595 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

2001 • 513 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.

1995 • 487 citations

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE

2007 • 452 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8⁺T cells in autoimmune diabetes

2003 • 378 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Oral Tolerance: Mechanisms and Therapeutic Applications

1999 • 318 citations

CD3-specific antibody-induced active tolerance: from bench to bedside

2003 • 305 citations

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway

2006 • 303 citations

Epitope spreading

1996 • 302 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

GRAIL

2003 • 280 citations

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

1993 • 280 citations

Use of Inhaled Insulin in a Basal/Bolus Insulin Regimen in Type 1 Diabetic Subjects

2005 • 274 citations

Multiple sclerosis

2005 • 254 citations

Characterization of a new subpopulation of mouse CD8α+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential

2002 • 254 citations

Oral Tolerance: Therapeutic Implications for Autoimmune Diseases

2006 • 253 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

Oral insulin administration and residual (β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial

2000 • 239 citations

Mucosal CD8α⁺ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties

2003 • 231 citations

Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis

2004 • 230 citations

Treatment of rheumatoid arthritis with oral type II collagen: Results of a multicenter, double-blind, placebo-controlled trial

1998 • 219 citations

Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis

2004 • 218 citations

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.

1994 • 216 citations

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis

2000 • 212 citations

No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

2000 • 211 citations

The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells.

1979 • 207 citations

Therapeutic potential of oral tolerance

2004 • 204 citations

Copolymer 1 acts against the immunodominant epitope 82–100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking

1999 • 191 citations

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

2001 • 187 citations

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)

2003 • 177 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.

1992 • 163 citations

Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases

1995 • 158 citations

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

1997 • 158 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

Treatment with Nonmitogenic Anti-CD3 Monoclonal Antibody Induces CD4+ T Cell Unresponsiveness and Functional Reversal of Established Experimental Autoimmune Encephalomyelitis

2005 • 141 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Translational Mini-Review Series on Type 1 Diabetes: Immune-based therapeutic approaches for type 1 diabetes

2007 • 140 citations

Immunological responses to fed protein antigens in mice. I. Reversal of oral tolerance to ovalbumin by cyclophosphamide.

1982 • 136 citations

Oral Tolerance in Experimental Autoimmune Encephalomyelitis

1996 • 136 citations

Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.

2002 • 131 citations

IL-4, IL-10, IL-13, and TGF-β from an Altered Peptide Ligand-Specific Th2 Cell Clone Down-Regulate Adoptive Transfer of Experimental Autoimmune Encephalomyelitis

2000 • 128 citations

DNA immunization to prevent autoimmune diabetes

1999 • 123 citations

Peripheral Tolerance Induction Using Ethylenecarbodiimide-Fixed APCs Uses both Direct and Indirect Mechanisms of Antigen Presentation for Prevention of Experimental Autoimmune Encephalomyelitis

2007 • 119 citations

Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein.

1996 • 111 citations

The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance

2002 • 106 citations

Treatment of new‐onset type 1 diabetes with peptide DiaPep277^® is safe and associated with preserved beta‐cell function: extension of a randomized, double‐blind, phase II trial

2006 • 105 citations

Reactivation of JC virus and development of PML in patients with multiple sclerosis

2007 • 100 citations

The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells

2004 • 99 citations

Oral Tolerance: Overview and Historical Perspectives

2004 • 97 citations

Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes

2001 • 94 citations

Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities

2006 • 87 citations

Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis

2005 • 87 citations

CD4+CD25+regulatory T cells generated in response to insulin B:9–23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells

2003 • 80 citations

Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction.

1990 • 77 citations

Immunomodulation in Type 1 Diabetes by NBI‐6024, an Altered Peptide Ligand of the Insulin B₍₉₋₂₃₎ Epitope

2005 • 71 citations

A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis

2005 • 71 citations

Reversal of acute experimental autoimmune encephalomyelitis and prevention of relapses by treatment with a myelin basic protein peptide analogue modified to form long-lived peptide-MHC complexes.

1995 • 70 citations

Oral Administration of Myelin Basic Protein Is Superior to Myelin in Suppressing Established Relapsing Experimental Autoimmune Encephalomyelitis

1999 • 70 citations

Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition.

1992 • 66 citations

Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85VVHFFKNIVTP96 in chronic progressive multiple sclerosis

1997 • 66 citations

Plasmid DNAs Encoding Insulin and Glutamic Acid Decarboxylase 65 Have Distinct Effects on the Progression of Autoimmune Diabetes in Nonobese Diabetic Mice

2001 • 63 citations

Oral Insulin Therapy to Prevent Progression of Immune‐Mediated (Type 1) Diabetes

2004 • 60 citations

Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-β mRNA

1997 • 58 citations

Current Issues in the Treatment of Human Diseases by Mucosal Tolerance

2004 • 57 citations

E3 Ligases in T Cell Anergy—Turning Immune Responses into Tolerance

2004 • 54 citations

Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance.

1991 • 53 citations

Intravenous antigen adrmnistration as a therapy for autoimmune demyelinating disease

1996 • 53 citations

Induction of antigen-specific tolerance for the treatment of ongoing, relapsing autoimmune encephalomyelitis: a comparison between oral and peripheral tolerance.

1997 • 51 citations

Suppression of experimental autoimmune thyroiditis in guinea pigs by pretreatment with thyroglobulin-coupled spleen cells

1980 • 50 citations

Inhibition of relapsing experimental autoimmune encephalomyelitis in SJL mice by feeding the immunodominant PLP139-151 peptide

1996 • 48 citations

Regulation of IgE antibody production by serum molecules. I. Serum from complete Freund's adjuvant-immune donors suppresses irradiation-enhanced IgE production in low responder mouse strains.

1978 • 47 citations

Randomized, double-blind, dose-comparison study of glatiramer acetate in relapsing–remitting MS

2007 • 46 citations

Antigen-Specific Tolerance as a Therapy for Experimental Autoimmune Encephalomyelitis

1992 • 43 citations

Induction of Peripheral Tolerance with Peptide-Specific Anergy in Experimental Autoimmune Neuritis

1993 • 41 citations

Modified amino acid copolymers suppress myelin basic protein 85–99-induced encephalomyelitis in humanized mice through different effects on T cells

2004 • 38 citations

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis

2005 • 35 citations

A View on Beta Cell Transplantation in Diabetes

2002 • 35 citations

Administration of myelin basic protein-coupled spleen cells prevents experimental allergic encephalitis

1983 • 34 citations

Complexities of applying nasal tolerance induction as a therapy for ongoing relapsing experimental autoimmune encephalomyelitis (EAE) in DA rats

1998 • 34 citations

T cell recognition of self and altered self antigens.

1997 • 32 citations

Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines

2002 • 32 citations

Prevention and treatment of relapsing autoimmune encephalomyelitis with myelin peptide-coupled splenocytes

1996 • 31 citations

Inhibition of experimental autoimmune uveitis by retinal photoreceptor antigens coupled to spleen cells

1992 • 30 citations

Regulation of IgE antibody production by serum molecules. IV. Complete Freund's adjuvant induces both enhancing and suppressive activities detectable in the serum of low and high responder mice.

1979 • 29 citations

Treatment of chronic relapsing experimental allergic encephalomyelitis with the intravenous administration of splenocytes coupled to encephalitogenic peptide 91–103 of myelin basic protein

1991 • 29 citations

Differential susceptibility of human Th1 versus T h 2 cells to induction of anergy and apoptosis by ECDI/antigen-coupled antigen-presenting cells

2000 • 28 citations

Cytokine profile and insulin antibody IgG subclasses in patients with recent onset Type 1 diabetes treated with oral insulin

2004 • 24 citations

Antigen-specific inhibition of the adoptive transfer of experimental autoimmune enceophalomyelitis in Lewis rats

1992 • 23 citations

DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice

2005 • 18 citations

Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs

2001 • 15 citations

Regulation of IgE Antibody Production by Serum Molecules

1979 • 15 citations

Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes

2004 • 14 citations