A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

A Multiple Comparison Procedure for Comparing Several Treatments with a Control

1955 • 5,730 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

A thousand and one protein kinases

1987 • 1,066 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.

1977 • 659 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Rapid protein kinase assay using phosphocellulose-paper absorption

1975 • 363 citations

Stimulation of corneal endothelial cell proliferation in vitro by fibroblast and epidermal growth factors

1977 • 335 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

Identification and characterization of a mitogen-activated S6 kinase.

1988 • 223 citations

[6] Catalytic subunit of cAMP-dependent protein kinase

1983 • 211 citations

The heterogeneity of protein kinase C in various rat tissues

1988 • 208 citations

Affinity chromatography of protein kinase C-phorbol ester receptor on polyacrylamide-immobilized phosphatidylserine.

1984 • 205 citations

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1987 • 189 citations

A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages

1985 • 152 citations

Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors

1987 • 148 citations

Tumor promoters: Effects on proliferation and differentiation of cells in culture

1978 • 145 citations

Priming of the respiratory burst of neutrophils by diacylglycerol. Independence from activation or translocation of protein kinase C.

1987 • 112 citations

Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding.

1985 • 94 citations

[26] Phosphorylase kinase from rabbit skeletal muscle

1983 • 89 citations

Immunological quantitation of phospholipid/CA²⁺‐dependent protein kinase of human mammary carcinoma cells: Inverse relationship to estrogen receptors

1987 • 86 citations

Selective phosphorylation of human DNA methyltransferase by protein kinase C

1986 • 50 citations

A system for obtaining large numbers of cryopreserved human monocytes purified by leukapheresis and Counter-current Centrifugation Elutriation (CCE)

1983 • 44 citations

Subcellular distribution of protein kinase C of GH3 cells: Quantitation and characterization by polyacrylamide gel electrophoresis

1985 • 43 citations

Synthetic peptide substrates for the membrane tyrosine protein kinase stimulated by epidermal growth factor

1984 • 39 citations

A comparison of the response of human lung carcinoma xenografts to vindesine and vincristine

1982 • 20 citations