Phagocyte NADPH Oxidase p67-phoxPossesses a Novel Carboxylterminal Binding Site for the GTPases Rac2 and Cdc42

Studies on the transformation of intact yeast cells by the LiAc/SS‐DNA/PEG procedure

1995 • 2,001 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

1997 • 192 citations

Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane

1994 • 180 citations

A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease.

1986 • 168 citations

Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex

1998 • 147 citations

Rac Binding to p67

1997 • 135 citations

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

1995 • 126 citations

The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1

1996 • 110 citations

Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins

1993 • 108 citations

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors

1995 • 93 citations

Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.

1994 • 90 citations

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease.

1996 • 87 citations

A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils

1995 • 80 citations

Interactions between the Cytosolic Components p47 and p67 of the Human Neutrophil NADPH Oxidase That Are Not Required for Activation in the Cell-free System

1995 • 78 citations

Characterization of the Effector-specifying Domain of Rac Involved in NADPH Oxidase Activation

1995 • 74 citations

Stoichiometry of p22-phox and gp91-phox in phagocyte cytochrome b558

1995 • 65 citations

Low-molecular-weight GTP-binding proteins and leukocyte signal transduction

1995 • 61 citations

Inhibition of NADPH oxidase activation by synthetic peptides mapping within the carboxyl-terminal domain of small GTP-binding proteins. Lack of amino acid sequence specificity and importance of polybasic motif.

1994 • 56 citations

Role of the rac1 p21‐GDP‐dissociation inhibitor for rho heterodimer in the activation of the superoxide‐forming NADPH oxidase of macrophages

1993 • 49 citations

Translocation of p21rac2 from Cytosol to Plasma Membrane Is Neither Necessary nor Sufficient for Neutrophil NADPH Oxidase Activity

1995 • 41 citations

Guanine Nucleotide Binding Properties of Rac2 Mutant Proteins and Analysis of the Responsiveness to Guanine Nucleotide Dissociation Stimulator^,

1997 • 30 citations

Regulation of phagocyte function by low molecular weight GTP-binding proteins

1993 • 19 citations

Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein

1993 • 10 citations