A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

The extinction coefficient of cytochrome c

1962 • 693 citations

Enzymes of Glycerolipid Synthesis in Eukaryotes

1980 • 626 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.

1977 • 315 citations

Phospholipids as ionophores.

1976 • 275 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Chemoattractant-Regulated Mobilization of a Novel Intracellular Compartment in Human Neutrophils

1987 • 256 citations

Leukotriene B4 and phosphatidic acid are calcium ionophores. Studies employing arsenazo III in liposomes.

1982 • 241 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.

1985 • 234 citations

Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines

1985 • 224 citations

Synthesis of fatty acid anhydrides by reaction with dicyclohexylcarbodiimide

1966 • 218 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils

1984 • 189 citations

The rate of transmembrane movement of cholesterol in the human erythrocyte.

1981 • 179 citations

Studies on alkaline phosphatase. Inhibition by phosphate derivatives and the substrate specificity

1967 • 175 citations

Phosphorylation, transbilayer movement, and facilitated intracellular transport of diacylglycerol are involved in the uptake of a fluorescent analog of phosphatidic acid by cultured fibroblasts.

1985 • 174 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells.

1981 • 135 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Cytochalasin B enhancement of the diacylglycerol response in formyl peptide-stimulated neutrophils.

1986 • 133 citations

Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene.

1990 • 116 citations

Priming of neutrophils and macrophages for enhanced release of superoxide anion by the calcium ionophore ionomycin. Implications for regulation of the respiratory burst.

1987 • 108 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.

1986 • 106 citations

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.

1992 • 105 citations

Modulation of rat brain cytosolic phosphatidate phosphohydrolase: Effect of cationic amphiphilic drugs and divalent cations

1987 • 103 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localization

1991 • 98 citations

Propranolol-induced inhibition of rat brain cytoplasmic phosphatidate phosphohydrolase

1983 • 92 citations

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid

1989 • 88 citations

Density heterogeneity of neutrophilic polymorphonuclear leukocytes: gradient fractionation and relationship to chemotactic stimulation

1983 • 85 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

1988 • 79 citations

Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function

1990 • 75 citations

Regulation of the translocation of phosphatidate phosphohydrolase between the cytosol and the endoplasmic reticulum of rat liver. Effects of unsaturated fatty acids, spermine, nucleotides, albumin and chlorpromazine

1985 • 72 citations

Intracellular activation of protein kinase C and regulation of the surface transferrin receptor by diacylglycerol is a spontaneously reversible process that is associated with rapid formation of phosphatidic acid.

1986 • 70 citations

Expression of active, membrane-bound human placental alkaline phosphatase by transfected simian cells.

1987 • 69 citations

Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes

1992 • 69 citations

Rapid transbilayer movement of phospholipids induced by an asymmetrical perturbation of the bilayer

1978 • 68 citations

Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells.

1992 • 63 citations

Detection of a phosphatidylinositol-specific phospholipase C at the surface of Swiss 3T3 cells and its potential role in the regulation of cell growth.

1990 • 63 citations

Evidence that neutral spingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane

1984 • 55 citations

Mitogenic Action of Lysophosphatidic Acid

1991 • 50 citations

Alkaline phosphatase as a reporter enzyme

1988 • 44 citations

Physical evidence for the presence of two forms of phosphatidate phosphohydrolase in rat liver

1992 • 39 citations

Further characterization of a novel phospholipase B (phospholipase A₂ – lysophospholipase) from intestinal brush-border membranes

1991 • 35 citations

Rat alkaline phosphatase

1987 • 30 citations

Effects of Phosphatidic Acid on Islet Cell Phosphoinositide Hydrolysis, Ca2+, and Adenylate Cyclase

1989 • 30 citations

Counter-regulatory effects of phosphatidic acid on protein kinase C activity in the presence of calcium and diolein

1990 • 29 citations

Transbilayer movement and metabolic fate of ether-linked phosphatidic acid (1-O-Octadecyl-2-acetyl-sn-glycerol 3-phosphate) in guinea pig peritoneal polymorphonuclear leukocytes.

1992 • 26 citations

Stimulatory Effects of a Short Chain Phosphatidate on Superoxide Anion Production in Guinea Pig Polymorphonuclear Leukocytes1

1989 • 24 citations

Regulation of phosphatidic acid phosphohydrolase activity during stimulation of human polymorphonuclear leukocytes

1992 • 22 citations

Characterization of phosphatidic acid phosphohydrolase in neutrophil subcellular fractions

1993 • 10 citations

Comparative study on the stimulation of superoxide production in guinea-pig eosinophils by the calcium ionophore A23187

1987 • 9 citations

Molecular cloning of MER-2, a human chromosome-11-encoded red blood cell antigen, using linkage of cotransfected markers

1987 • 7 citations

Selective extraction, concentration, and assay of orthophosphate from microliter quantities of cultured mammalian cells

1989 • 5 citations