Fluoride activates diradylglycerol and Superoxide generation in human neutrophils via PLD/PA phosphohydrolase-dependent and -independent pathways

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

The extinction coefficient of cytochrome c

1962 • 693 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Fluoroaluminates activate transducin‐GDP by mimicking the γ‐phosphate of GTP in its binding site

1985 • 420 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet.

1985 • 270 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils

1984 • 189 citations

Receptor-Mediated Internalization of Fluorescent Chemotactic Peptide by Human Neutrophils

1979 • 188 citations

Regulation of neutrophil NADPH oxidase activation in a cell-free system by guanine nucleotides and fluoride. Evidence for participation of a pertussis and cholera toxin-insensitive G protein.

1987 • 188 citations

Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism

1986 • 181 citations

Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process.

1979 • 170 citations

Superoxide production induced in rabbit polymorphonuclear leukocytes by synthetic chemotactic peptides and A23187.

1979 • 158 citations

Unsaturated fatty acids as second messengers of superoxide generation by macrophages

1983 • 157 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.

1986 • 148 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Cytochalasin B enhancement of the diacylglycerol response in formyl peptide-stimulated neutrophils.

1986 • 133 citations

Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.

1985 • 124 citations

Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids

1982 • 116 citations

Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase

1989 • 112 citations

Diacylglycerol accumulation and superoxide anion production in stimulated human neutrophils.

1987 • 103 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

Membrane‐cytoskeleton interactions and the regulation of chemotactic peptide‐induced activation of human granulocytes: The effects of dihydrocytochalasin B

1985 • 84 citations

Activation of the respiratory burst oxidase in neutrophils: On the role of membrane-derived second messengers, Ca++, and protein kinase C

1988 • 83 citations

Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.

1985 • 83 citations

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

1988 • 79 citations

Calcium mobilization in fluoride activated human neutrophils

1985 • 71 citations

Differential activation by fMet‐Leu‐Phe and phorbol ester of a plasma membrane phosphatidylcholine‐specific phospholipase D in human neutrophil

1989 • 63 citations

On the Biological Occurrence and Regulation of 1-Acyl and 1-O-Alkyl-diradylglycerols in Human Neutrophils

1989 • 59 citations

Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes

1989 • 59 citations

1,2-dioctanoyl-sn-glycerol can stimulate neutrophils by different mechanisms

1989 • 58 citations

Biochemical characterization of phospholipase D activity from human neutrophils

1989 • 55 citations

Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose

1986 • 50 citations

A method for the quantitative determination of glycerolipids containing O-alkyl and O-alk-1-enyl moieties

1975 • 48 citations

Diacylglycerol generation and phosphoinositide turnover in human neutrophils: Effects of particulate versus soluble stimuli

1989 • 41 citations

Relationship of phosphatidylinositol bisphosphate hydrolysis to calcium mobilization and functional activation in fluoride-treated neutrophils.

1987 • 35 citations

Diverse involvements of Ni protein in superoxide anion production in polymorphonuclear leukocytes depending on the type of membrane stimulants

1985 • 28 citations

Granulocyte/macrophage colony‐stimulating factor primes human neutrophils for increased diacylglycerol generation in response to chemoattractant

1989 • 24 citations

The effect of inhibition of both diacylglycerol metabolism and phospholipase A₂ activity on superoxide generation by human neutrophils

1988 • 18 citations