Phospholipase D

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

The Granulocyte-Macrophage Colony-Stimulating Factors

1985 • 1,007 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues

1996 • 318 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Coordination of membrane phospholipid synthesis with the cell cycle.

1994 • 281 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils.

1992 • 252 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.

1994 • 250 citations

A Glycan-Phosphatidylinositol-Specific Phospholipase D in Human Serum

1987 • 248 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Cell Cycle Regulation of Membrane Phospholipid Metabolism

1996 • 215 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 210 citations

Phospholipase D signaling is essential for meiosis.

1995 • 208 citations

Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases.

1993 • 201 citations

C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

1992 • 198 citations

Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L.

1994 • 185 citations

Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst ¹

1993 • 184 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 176 citations

Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex

1997 • 174 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Transgenic Mice Overexpressing Glutathione Peroxidase are Resistant to Myocardial Ischemia Reperfusion Injury

1996 • 171 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

The phosphatidylcholine pathway of diacylglycerol formation stimulated by phorbol diesters occurs via phospholipase D activation

1988 • 156 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Partial purification and properties of a rat brain phospholipase.

1979 • 149 citations

Influx of neutrophils into the walls of large epicardial coronary arteries in response to ischemia/reperfusion.

1991 • 149 citations

Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase.

1994 • 149 citations

Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cells

1988 • 149 citations

Regulation of Phospholipase D in HL60 Cells

1995 • 145 citations

Partial Purification and Characterization of Arf-sensitive Phospholipase D from Porcine Brain

1995 • 143 citations

Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.

1992 • 141 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Isolation of human eosinophil phospholipase D.

1976 • 139 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Purification and characterization of phosphatidylcholine phospholipase D from pig lung.

1994 • 137 citations

Rac Binding to p67

1997 • 135 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2.

1994 • 133 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase

1990 • 129 citations

Primary Structure and Functional Activity of a Phosphatidylinositol-Glycan-Specific Phospholipase D

1991 • 126 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucyl-phenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release.

1991 • 115 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity

1995 • 112 citations

v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine.

1991 • 111 citations

Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation.

1990 • 110 citations

ON THE NATURE OF THE PHOSPHORUS-CONTAINING LIPIDES OF CABBAGE LEAVES AND THEIR RELATION TO A PHOSPHOLIPIDE-SPLITTING ENZYME CONTAINED IN THESE LEAVES

1948 • 107 citations

Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.

1991 • 106 citations

Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells

1992 • 104 citations

Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.

1989 • 102 citations

Guanine nucleotides induce tyrosine phosphorylation and activation of the respiratory burst in neutrophils

1989 • 101 citations

A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterization.

1990 • 100 citations

G-Protein-coupled receptors in HL-60 human leukemia cells

1996 • 99 citations

RalA Interacts Directly with the Arf-Responsive, PIP2-Dependent Phospholipase D1

1997 • 97 citations

Phosphatidic acid and diacylglycerol synergize in a cell-free system for activation of NADPH oxidase from human neutrophils.

1993 • 96 citations

ADP-ribosylation Factor Translocation Correlates with Potentiation of GTPγS-stimulated Phospholipase D Activity in Membrane Fractions of HL-60 Cells

1995 • 95 citations

Expression of Phospholipase D during Castor Bean Leaf Senescence

1995 • 92 citations

Cell-free activation of neutrophil NADPH oxidase by a phosphatidic acid-regulated protein kinase.

1995 • 90 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

Phospholipases: structural and functional motifs for working at an interface

1996 • 89 citations

Phosphatidylethanol formation in human platelets: Evidence for thrombin-induced activation of phospholipase D

1988 • 88 citations

Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

Human Phospholipase D1 Can Be Tyrosine-phosphorylated in HL-60 Granulocytes

1997 • 85 citations

Nuclear Translocation of RhoA Mediates the Mitogen-induced Activation of Phospholipase D Involved in Nuclear Envelope Signal Transduction

1997 • 83 citations

Nuclear Phospholipase D in Madin-Darby Canine Kidney Cells

1995 • 82 citations

Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.

1994 • 80 citations

Tissue-specific distribution and subcellular distribution of phospholipase D in rat: evidence for distinct RhoA- and ADP-ribosylation factor (ARF)-regulated isoenzymes

1996 • 80 citations

Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein- and tyrosine kinase-based mechanisms

1993 • 78 citations

Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line

1989 • 78 citations

Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol.

1990 • 78 citations

12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates

1988 • 78 citations

Multiple Forms of Phospholipase D following Germination and during Leaf Development of Castor Bean

1994 • 78 citations

Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation

1991 • 78 citations

Cloning, nucleotide sequence, and expression in Escherichia coli of the phospholipase D gene from Corynebacterium pseudotuberculosis

1990 • 77 citations

Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.

1994 • 76 citations

Functional characterization of beta isoforms of murine Na,K-ATPase. The adhesion molecule on glia (AMOG/beta 2), but not beta 1, promotes neurite outgrowth.

1993 • 75 citations

A Phospholipase D-mediated Pathway for Generating Diacylglycerol in Nuclei from Madin-Darby Canine Kidney Cells

1995 • 73 citations

ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells

1996 • 72 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Human neutrophils contain distinct cytosolic and particulate tyrosine kinase activities: possible role in neutrophil activation

1989 • 71 citations

Phospholipase D fromStreptomyces antibioticus: Cloning, sequencing, expression, and relationship to other phospholipases

1994 • 68 citations

Granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation of microtubule-associated protein kinase in human neutrophils.

1992 • 66 citations

Superoxide production by cytochrome b₅₅₉

1994 • 66 citations

Regulation of phospholipase D by tyrosine kinases

1996 • 64 citations

Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor

1991 • 62 citations

The translocation of respiratory burst oxidase components from cytosol to plasma membrane is regulated by guanine nucleotides and diacylglycerol.

1992 • 61 citations

Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.

1994 • 60 citations

Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1997 • 59 citations

Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.

1992 • 58 citations

Granulocyte-macrophage colony-stimulating factor activates microtubule- associated protein 2 kinase in neutrophils via a tyrosine kinase- dependent pathway

1992 • 57 citations

Biochemical characterization of phospholipase D activity from human neutrophils

1989 • 55 citations

Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils

1993 • 55 citations

Prostaglandin F_2α activates phospholipase D independently from activation of protein kinase C in osteoblast‐like cells

1994 • 51 citations

ATP-induced potentiation of G-protein-dependent phospholipase D activity in a cell-free system from U937 promonocytic leukocytes.

1993 • 50 citations

Divergent effects of propranolol on neutrophil superoxide release: Involvement of phosphatidic acid and diacylglycerol as second messengers

1991 • 49 citations

S6 Kinase p90 in Granulocyte-Macrophage Colony-stimulating Factor-stimulated Proliferative and Mature Hematopoietic Cells

1996 • 48 citations

Ras effector-homolog region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex

1994 • 48 citations

Phorbol-12-myristate-13-acetate activation of phospholipase D in human neutrophils leads to the production of phosphatides and diglycerides

1990 • 48 citations

Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes

1990 • 47 citations

Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human nerutrophils in vitro: Role of calcium, G-proteins and tyrosine kinases

1992 • 46 citations

Phorbol ester-induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophil cytoplasts

1995 • 45 citations

Involvement of Tyrosine Phosphorylation in IgE Receptor-Mediated Phospholipase D Activation in Rat Basophilic Leukemia (RBL-2H3) Cells

1993 • 44 citations

Tamoxifen activates cellular phopholipase C and D and elicits protein kinase C translocation

1997 • 43 citations

Cell-free translocation of recombinant p47-phox, a component of the neutrophil NADPH oxidase: effects of guanosine 5'-O-(3-thiotriphosphate), diacylglycerol, and an anionic amphiphile

1992 • 43 citations

Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium.

1993 • 41 citations

Fluoride activates diradylglycerol and Superoxide generation in human neutrophils via PLD/PA phosphohydrolase-dependent and -independent pathways

1990 • 35 citations

Guanine Nucleotide‐Binding Protein Regulation of Microsomal Phospholipase D Activity of Canine Cerebral Cortex

1990 • 33 citations

Immunoprecipitation of a Phospholipase D Activity with Antiphosphotyrosine Antibodies

1995 • 30 citations

Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.

1994 • 27 citations

Regulation of neutrophil responses by phosphotyrosine phosphatase.

1994 • 26 citations

Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line

1989 • 25 citations

Role of protein kinase Cα, arf, and cytoplasmic calcium transients in phospholipase D activation by sodium fluoride in osteoblast-like cells

1996 • 23 citations

Metal ion stimulation of phospholipase D‐like activity of isolated rat intestinal mitochondria

1997 • 21 citations

Regulation of phospholipase C and D activities by small molecular weight G proteins and muscarinic receptors

1997 • 19 citations

Expression of intracellular and GPI-anchored forms of GPI-specific phospholipase D in COS-1 cells

1997 • 19 citations

Potential Role of Protein Phosphorylation in GTP-γ-S-Dependent Activation of Phospholipase D

1995 • 18 citations

Emerging paradigms in granulocyte-macrophage colony-stimulating factor signaling

1996 • 17 citations

Calcium-Independent Activation of Protein Kinase C by the Dianionic Form of Phosphatidic Acid

1993 • 17 citations

Characterization and partial purification of phospholipase D from human placenta

1995 • 17 citations

Tyrosine kinase regulates phospholipase D activation at a point downstream from protein kinase C in osteoblast‐like cells

1995 • 16 citations

The C-terminus of glycosylphosphatidylinositol-specific phospholipase D is essential for biological activity

1997 • 15 citations

Phospholipase D Activity in PC12 Cells

1997 • 12 citations

Phosphatidic Acid-Induced Translocation of Cytosolic Components in a Cell-Free System of NADPH Oxidase: Mechanism of Activation and Effect of Diacylglycerol

1996 • 12 citations

Small GTPase-regulated phospholipase D in granulocytes

1996 • 12 citations

Role of diradylglycerol formation in H2O2 and lactoferrin release in adherent human polymorphonuclear leukocytes

1994 • 11 citations

Experience with teicoplanin in non‐inpatient therapy in children with central line infections

1997 • 8 citations

[29] Reconstitution of cell-free NADPH oxidase activity by purified components

1995 • 7 citations

Cellular localization of the inhibitory action of abruquinone A against respiratory burst in rat neutrophils

1997 • 7 citations

Modulation of phospholipase D stimulation in c-src transfected mesangial cells

1997 • 4 citations