Arachidonic acid increases the activity of the assembled NADPH oxidase in cytoplasmic membranes and endosomes

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

The respiratory burst of phagocytes.

1984 • 914 citations

Rapid Charcoal Assay for Intrinsic Factor (IF), Gastric Juice Unsaturated B12 Binding Capacity, Antibody to IF, and Serum Unsaturated B12 Binding Capacity

1965 • 743 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells

1989 • 353 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

1988 • 327 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

Genetic Variants of Chronic Granulomatous Disease: Prevalence of Deficiencies of Two Cytosolic Components of the NADPH Oxidase System

1989 • 258 citations

Chemoattractant-Regulated Mobilization of a Novel Intracellular Compartment in Human Neutrophils

1987 • 256 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Mononuclear Phagocytes; Functional Aspects

1981 • 215 citations

The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme.

1979 • 210 citations

Activation of neutrophil NADPH oxidase in a cell-free system. Partial purification of components and characterization of the activation process.

1987 • 202 citations

Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein.

1984 • 187 citations

Unsaturated fatty acids as second messengers of superoxide generation by macrophages

1983 • 157 citations

Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.

1988 • 153 citations

Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression.

1990 • 137 citations

Enzymatic basis of macrophage activation. Kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes.

1984 • 128 citations

Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids

1988 • 120 citations

Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase.

1983 • 120 citations

Studies on the Na+ + K+ activated ATP hydrolysing enzyme system the role of SH groups

1963 • 116 citations

MICROSPECTROFLUOROMETRIC APPROACH TO THE STUDY OF FREE/BOUND NAD(P)H RATIO AS METABOLIC INDICATOR IN VARIOUS CELL TYPES

1982 • 106 citations

Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils.

1991 • 103 citations

Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.

1987 • 98 citations

A phosphoprotein of Mr 47,000, defective in autosomal chronic granulomatous disease, copurifies with one of two soluble components required for NADPH:O2 oxidoreductase activity in human neutrophils.

1989 • 87 citations

Regulation of the oxidative response of human granulocytes to chemoattractants. No evidence for stimulated traffic of redox enzymes between endo and plasma membranes.

1985 • 85 citations

Cytochrome b translocation to human neutrophil plasma membranes and superoxide release. Differential effects of N-formylmethionylleucylphenylalanine, phorbol myristate acetate, and A23187.

1985 • 78 citations

Chinese hamster ovary cell mutants with temperature-sensitive defects in endocytosis. I. Loss of function on shifting to the nonpermissive temperature.

1986 • 77 citations

Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity

1990 • 71 citations

Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils.

1989 • 66 citations

Dual granule localization of the dormant NADPH oxidase and cytochrome b₅₅₉ in human neutrophils

1989 • 65 citations

Arachidonic acid activates Ca2+ extrusion in macrophages.

1990 • 56 citations

Isolation from neutrophil membranes of a complex containing active NADPH oxidase and cytochrome b-245

1984 • 44 citations

ATP and guanine nucleotide dependence of neutrophil activation. Evidence for the involvement of two distinct GTP-binding proteins.

1990 • 43 citations

Isolation of human neutrophil plasma membranes employing neutrophil cytoplasts and changes in the cell-surface proteins upon cell activation

1986 • 35 citations

Stimulation of the respiratory burst in peripheral blood monocytes by lipoteichoic acid. The involvement of calcium ions and phospholipase A2.

1990 • 33 citations

Difference in hydrogen peroxide release between human neutrophils and neutrophil cytoplasts following calcium ionophore activation. A role of the subcellular granule in activation of the NADPH-oxidase in human neutrophils?

1989 • 33 citations

Saturated and trans-unsaturated fatty acids elicit high levels of superoxide generation in intact and cell-free preparations of neutrophils

1987 • 29 citations

The subcellular distribution of platelet-activating factor in stimulated human neutrophils.

1990 • 27 citations

Activation of NADPH oxidase in human neutrophils permeabilized with Staphylococcus aureus alpha-toxin. A lower Km when the enzyme is activated in situ.

1992 • 26 citations

Respiratory burst of rabbit peritoneal neutrophils

1990 • 21 citations

The effect of inhibition of both diacylglycerol metabolism and phospholipase A₂ activity on superoxide generation by human neutrophils

1988 • 18 citations

The erythrocyte membrane in essential hypertension characterization of the temperature dependence of lithium efflux

1984 • 15 citations

Activation-associated alterations in neutrophil pyridine nucleotide levels: a potential regulatory role for calcium and calmodulin

1985 • 13 citations

Subcellular localization and dynamics of components of the respiratory burst oxidase

1988 • 13 citations

Inhibition of cap formation on lymphocytes by free fatty acids is not mediated by a depletion of ATP.

1982 • 11 citations