Products of Sphingolipid Catabolism Block Activation of the p21-Activated Protein Kinases in Neutrophils

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1997 • 422 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation.

1998 • 336 citations

Quantitation of free sphingosine in liver by high-performance liquid chromatography

1988 • 315 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

p38 Mitogen-Activated Protein Kinase Activation Is Required for Human Neutrophil Function Triggered by TNF-α or FMLP Stimulation

1998 • 269 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

1997 • 259 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Cell regulation by sphingosine and more complex sphingolipids

1991 • 242 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin.

1984 • 230 citations

Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases

1998 • 223 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

1993 • 179 citations

Importance of MEK in Neutrophil Microbicidal Responsiveness

1998 • 155 citations

Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex

1998 • 147 citations

Antagonists of Phosphatidylinositol 3-Kinase Block Activation of Several Novel Protein Kinases in Neutrophils

1995 • 127 citations

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.

1988 • 119 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

Activation of Myosin-I by Members of the Ste20p Protein Kinase Family

1996 • 100 citations

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1991 • 97 citations

Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.

1988 • 97 citations

Activation of p21-CDC42/Rac-Activated Kinases by CD28 Signaling: p21-Activated Kinase (PAK) and MEK Kinase 1 (MEKK1) May Mediate the Interplay Between CD3 and CD28 Signals

1998 • 80 citations

p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I

1997 • 79 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

Farber's lipogranulomatosis

1969 • 73 citations

Differential Effects of a Mitogen-Activated Protein Kinase Kinase Inhibitor on Human Neutrophil Responses to Chemotactic Factors

1997 • 72 citations

N-Acetylsphingosine (C2--ceramide) Inhibited Neutrophil Superoxide Formation and Calcium Influx

1995 • 68 citations

Type C Niemann-Pick disease: A murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver

1992 • 64 citations

Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1997 • 59 citations

The Renaturable 69- and 63-kDa Protein Kinases That Undergo Rapid Activation in Chemoattractant-stimulated Guinea Pig Neutrophils Are p21-Activated Kinases

1996 • 59 citations

The Catalytic Domain of Acanthamoeba Myosin I Heavy Chain Kinase

1996 • 56 citations

Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.

1997 • 56 citations

Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase substrate

1993 • 55 citations

Membrane-Destabilizing Properties of C₂-Ceramide May Be Responsible for Its Ability To Inhibit Platelet Aggregation

1998 • 53 citations

Receptor-mediated activation of multiple serine/threonine kinases in human leukocytes.

1993 • 51 citations

Neutrophils stimulated with a chemotactic peptide or a phorbol ester exhibit different alterations in the activities of a battery of protein kinases.

1993 • 39 citations

[19] NADH oxidase from guinea pig polymorphonuclear leukocytes

1986 • 34 citations

Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation

1994 • 25 citations

The Catalytic Domain of Acanthamoeba Myosin I Heavy Chain Kinase

1996 • 24 citations

Stimulation of a histone H4 protein kinase in Triton X‐100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: Lack of requirements of calcium mobilization and protein kinase C activation

1990 • 12 citations

Activation of the p21‐activated protein kinases from neutrophils with an antibody that reacts with the N‐terminal region of Pak 1

1997 • 6 citations