Crystal‐induced neutrophil activation. II. evidence for the activation of a phosphatidylcholine‐specific phospholipase D

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

G protein involvement in receptor-effector coupling.

1988 • 618 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

IDENTIFICATION OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUID

1961 • 479 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

ACUTE ARTHRITIS IN MAN AND DOG AFTER INTRASYNOVIAL INJECTION OF SODIUM URATE CRYSTALS

1962 • 265 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution.

1991 • 224 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Coomassie brilliant blue staining of lipids on thin-layer plates

1984 • 211 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Monocyte‐derived neutrophil chemotactic factor/interleukin‐8 is a potential mediator of crystal‐induced inflammation

1991 • 195 citations

Inflammatory microcrystals stimulate interleukin‐6 production and secretion by human monocytes and synoviocytes

1989 • 187 citations

Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilization

1984 • 180 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Molecular Basis of Gouty Inflammation: Interaction of Monosodium Urate Crystals with Lysosomes and Liposomes

1972 • 161 citations

Neutrophil-induced injury of rat pulmonary alveolar epithelial cells.

1986 • 153 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Activation of the Neutrophil (Part 1 of 4)

1988 • 149 citations

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1987 • 142 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Experimental inflammation induced by naturally occurring microcrystalline calcium salts.

1976 • 108 citations

Superoxide anion generation by human neutrophils exposed to monosodium urate. effect of protein adsorption and complement activation

1982 • 104 citations

Second messenger function of phosphatidic acid in platelet activation

1989 • 86 citations

Formation of leukotrienes and hydroxy acids by human neutrophils and platelets exposed to monosodium urate

1984 • 84 citations

Receptor-mediated phagocytosis in human neutrophils is associated with increased formation of inositol phosphates and diacylglycerol. Elevation in cytosolic free calcium and formation of inositol phosphates can be dissociated from accumulation of diacylglycerol.

1989 • 84 citations

Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol.

1990 • 78 citations

Differential activation by fMet‐Leu‐Phe and phorbol ester of a plasma membrane phosphatidylcholine‐specific phospholipase D in human neutrophil

1989 • 63 citations

Crystal‐induced endogenous pyrogen production. A further look at gouty inflammation

1985 • 61 citations

Stimulation of the respiratory burst in human neutrophils by crystal phagocytosis

1982 • 56 citations

Crystal-neutrophil interactions lead to interleukin-1 synthesis

1991 • 54 citations

Crystal‐induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals

1991 • 50 citations

Divergent effects of propranolol on neutrophil superoxide release: Involvement of phosphatidic acid and diacylglycerol as second messengers

1991 • 49 citations

The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil

1990 • 45 citations

Monosodium urate and calcium pyrophosphate crystals differentially activate the excitation-response coupling sequence of human neutrophils

1987 • 36 citations

Monosodium urate crystals stimulate phospholipase A2 enzyme activities and the synthesis of a phospholipase A2-activating protein.

1990 • 36 citations

Phorbol esters activate the pathway for phosphatidylethanol synthesis in differentiating HL-60 cells

1987 • 33 citations

A step sensitive to pertussis toxin and phorbol ester in human neutrophils regulates chemotaxis and capping but not phagocytosis

1986 • 31 citations

Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways.

1990 • 28 citations

Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: Evidence for an involvement of phospholipase D-derived phosphatidic acid

1991 • 22 citations

Crystals, inflammation, and osteoarthritis

1987 • 19 citations