Priming of Phosphatidic Acid Production by Staurosporine in f-Met-Leu-Phe-Stimulated Human Neutrophils—Correlation with Respiratory Burst

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Neutrophil priming: the cellular signals that say ‘amber’ but not ‘green’

1995 • 240 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

1988 • 190 citations

Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils

1983 • 188 citations

Talking point Amphitropic proteins: a new class of membrane proteins

1988 • 168 citations

Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes

1988 • 163 citations

Exposure of human neutrophils to chemotactic factors potentiates activation of the respiratory burst enzyme.

1983 • 157 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cells

1988 • 149 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol, and phosphatidic acid generation with superoxide anion generation.

1988 • 133 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.

1988 • 121 citations

Priming of the respiratory burst of neutrophils by diacylglycerol. Independence from activation or translocation of protein kinase C.

1987 • 112 citations

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.

1992 • 105 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils

1989 • 98 citations

Activation and substrate specificity of the human protein kinase C α and ζ isoenzymes

1993 • 96 citations

Phosphatidic acid and diacylglycerol synergize in a cell-free system for activation of NADPH oxidase from human neutrophils.

1993 • 96 citations

Cell-free activation of neutrophil NADPH oxidase by a phosphatidic acid-regulated protein kinase.

1995 • 90 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation

1991 • 78 citations

Association of ligand-receptor complexes with actin filaments in human neutrophils: a possible regulatory role for a G-protein.

1989 • 70 citations

Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C

1993 • 69 citations

Immunochemical identification and translocation of protein kinase C zeta in human neutrophils

1994 • 65 citations

Differential activation by fMet‐Leu‐Phe and phorbol ester of a plasma membrane phosphatidylcholine‐specific phospholipase D in human neutrophil

1989 • 63 citations

Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C.

1988 • 59 citations

Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH‐SY5Y human neuroblastoma cells through an α‐, β‐, and ζ‐protein kinase C‐independent pathway

1993 • 58 citations

Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by coomassie blue staining and densitometry

1989 • 56 citations

Granulocyte-Macrophage Colony-stimulating Factor Primes Neutrophils by Activating a Pertussis Toxin-sensitive G Protein Not Associated with Phosphatidylinositol Turnover

1989 • 56 citations

Regulation of phospholipase D-induced hydrolysis of choline-containing phosphoglycerides by cyclic AMP in human neutrophils.

1991 • 55 citations

Redistribution of Protein Kinase C Isoforms in Human Neutrophils Stimulated by Formyl Peptides and Phorbol-Myristate Acetate

1995 • 53 citations

A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.

1992 • 49 citations

The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil

1990 • 45 citations

A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.

1991 • 42 citations

Stimulus-specific induction of phospholipid and arachidonic acid metabolism in human neutrophils

1987 • 42 citations

Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine

1993 • 41 citations

The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post‐receptor mechanisms

1990 • 41 citations

Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor

1990 • 41 citations

Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin.

1990 • 36 citations

Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine

1992 • 35 citations

Staurosporine stimulates phospholipase D activation in human polymorphonuclear leukocytes

1993 • 29 citations

Stimulatory Effects of a Short Chain Phosphatidate on Superoxide Anion Production in Guinea Pig Polymorphonuclear Leukocytes1

1989 • 24 citations

Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: Evidence for an involvement of phospholipase D-derived phosphatidic acid

1991 • 22 citations

A protein kinase inhibitor, staurosporine, enhances the expression of phorbol dibutyrate binding sites in human polymorphonuclear leucocytes

1993 • 22 citations

Staurosporine up-regulates the expression of phorbol dibutyrate binding sites in human platelets

1994 • 7 citations