Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Alpha-toxin of Staphylococcus aureus

1991 • 758 citations

The Role of Leukotrienes in Inflammation

1994 • 581 citations

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.

1992 • 546 citations

The ins and outs of Raf kinases

1994 • 537 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Protein kinase C, calcium and phospholipid degradation

1992 • 400 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Release and metabolism of arachidonic acid in human neutrophils.

1981 • 281 citations

Gaining access to the cytosol: the technique and some applications of electropermeabilization

1986 • 275 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Protein kinase C-dependent and -independent pathways of mitogen-activated protein kinase activation in macrophages by stimuli that activate phospholipase A2.

1994 • 229 citations

Remodeling of arachidonate-containing phosphoglycerides within the human neutrophil.

1986 • 225 citations

FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.

1994 • 167 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Characterization of hormone and protein release from alpha-toxin-permeabilized chromaffin cells in primary culture.

1986 • 147 citations

Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.

1987 • 140 citations

Alcohol and Platelet Function

1994 • 139 citations

An 100‐kDa arachidonate‐mobilizing phospholipase A₂ in mouse spleen and the macrophage cell line J774

1991 • 136 citations

Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol, and phosphatidic acid generation with superoxide anion generation.

1988 • 133 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols

1988 • 128 citations

Mapping of the C5a receptor signal transduction network in human neutrophils.

1994 • 124 citations

Diacylglycerol potentiates phospholipase attack upon phospholipid bilayers: Possible connection with cell stimulation

1983 • 120 citations

Phospholipid Functional Groups Involved in Protein Kinase C Activation, Phorbol Ester Binding, and Binding to Mixed Micelles

1989 • 115 citations

Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.

1994 • 108 citations

Anionic phospholipids stimulate an arachidonoyl-hydrolyzing phospholipase A2 from macrophages and reduce the calcium requirement for activity

1990 • 107 citations

Structural and chemical specificity of diradylglycerols for protein kinase C activation

1984 • 92 citations

Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe.

1988 • 91 citations

Second messenger function of phosphatidic acid in platelet activation

1989 • 86 citations

Phospholipase A2 Regulates Critical Inflammatory Mediators of Multiple Organ Failure

1994 • 78 citations

Platelet-activating factor production in human neutrophils by sequential stimulation with granulocyte-macrophage colony-stimulating factor and the chemotactic factors C5A or formyl-methionyl-leucyl-phenylalanine.

1989 • 67 citations

Tumor necrosis factor-alpha priming of phospholipase A2 activation in human neutrophils. An alternative mechanism of priming.

1991 • 66 citations

Macrophage arachidonate-mobilizing phospholipase A2: Role of Ca2+ for membrane binding but not for catalytic activity

1992 • 64 citations

Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.

1992 • 58 citations

Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils.

1994 • 54 citations

The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its ω-metabolites

1987 • 51 citations

Coexistence of two biochemically distinct phospholipase A₂ activities in human platelet, monocyte, and neutrophil

1993 • 49 citations

Phosphatidic Acid Directly Activates Endothelial Cell Protein Kinase C

1993 • 47 citations

Regulation of phospholipase A2 activity in undifferentiated and neutrophil-like HL60 cells. Linkage between impaired responses to agonists and absence of protein kinase C-dependent phosphorylation of cytosolic phospholipase A2.

1994 • 44 citations

Stimulus-specific induction of phospholipid and arachidonic acid metabolism in human neutrophils

1987 • 42 citations

Effect of ethanol on platelet phospholipase A₂

1992 • 41 citations

Cytosolic phospholipase A2 from human monocytic cells: characterization of substrate specificity and Ca2+-dependent membrane association

1993 • 41 citations

Differential actions of diacyl- and alkylacylglycerols in priming phospholipase A2, 5-lipoxygenase and acetyltransferase activation in human neutrophils

1991 • 37 citations

Evidence That Activation of Phospholipase D can Mediate Secretion from Permeabilized Platelets

1993 • 34 citations

Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation

1996 • 30 citations

Phospholipase D: Regulation and Functional Significance

1993 • 27 citations

Activation of NADPH oxidase in human neutrophils permeabilized with Staphylococcus aureus alpha-toxin. A lower Km when the enzyme is activated in situ.

1992 • 26 citations

Activation of cytosolic phospholipase A2 in permeabilized human neutrophils

1996 • 25 citations

Angiotensin II induces phosphatidic acid formation in neonatal rat cardiac fibroblasts: Evaluation of the roles of phospholipases C and D

1994 • 21 citations

Arachidonic acid liberation induced by phosphatidic acid endogenously generated from membrane phospholipids in rabbit platelets

1994 • 20 citations

Preferential Activation of Phospholipase A2, by Low Concentrations of Phosphatidic Acid with Long-Chain Fatty Acids in Rabbit Platelets1

1992 • 15 citations

Ethanol inhibits zymosan-stimulated eicosanoid production in mouse peritoneal macrophages

1994 • 14 citations

Separation of agonist‐stimulated arachidonate mobilization from subsequent leukotriene B₄ synthesis in human neutrophils: Different effects of oleoylacetylglycerol and phorbol myristate acetate as priming agents

1994 • 12 citations

Involvement of phosphatidic acid, phosphatidate phosphohydrolase, and inositide-specific phospholipase D in neutrophil stimulus-response pathways.

1992 • 8 citations

Generation of phosphatidic acid and diacylglycerols following ligation of surface immunoglobulin in human B lymphocytes: Potential role in PKC activation

1992 • 7 citations

Effects of Diacylglycerol on the Activation and Kinetics of the Respiratory Burst Oxidase in a Cell-Free System from Human Neutrophils: Evidence That Diacylglycerol May Regulate Nucleotide Uptake by a GTP-Binding Protein

1993 • 5 citations