Gene Expression Profiling of Inflamed Human Endothelial Cells and Influence of Activated Protein C

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

Proinflammatory Cytokines

2000 • 1,857 citations

Treating Patients with Severe Sepsis

1999 • 1,006 citations

Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

2002 • 832 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases

1999 • 717 citations

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

2001 • 665 citations

Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

2001 • 655 citations

Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

1994 • 365 citations

Techniques in diagnostic human biochemical genetics

1991 • 348 citations

Endothelial cell heterogeneity

2003 • 323 citations

Cytokine induction of monocyte chemoattractant protein‐1 gene expression in human endothelial cells depends on the cooperative action of NF‐χB and AP‐1

1997 • 318 citations

The endothelium in sepsis: Source of and a target for inflammation

2001 • 289 citations

Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis

2001 • 273 citations

Role of Coagulation Inhibitors in Inflammation

2001 • 261 citations

Thrombomodulin

2003 • 219 citations

Transcriptional Regulation of Tissue Factor Expression in Human Endothelial Cells

1995 • 219 citations

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

2000 • 206 citations

Role of Activating Protein-1 in the Regulation of the Vascular Cell Adhesion Molecule-1 Gene Expression by Tumor Necrosis Factor-α

1998 • 190 citations

Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells

1998 • 89 citations

Transcriptional up-regulation of intracellular adhesion molecule-1 in human endothelial cells by the antioxidant pyrrolidine dithiocarbamate involves the activation of activating protein-1.

1996 • 85 citations

Lack of Role for Nitric Oxide (NO) in the Selective Destabilization of Endothelial NO Synthase mRNA by Tumor Necrosis Factor–α

1995 • 81 citations

Adenovirus-Mediated Overexpression of c-Jun and c-Fos Induces Intercellular Adhesion Molecule-1 and Monocyte Chemoattractant Protein-1 in Human Endothelial Cells

1999 • 75 citations

Multiple Transcription Factor Profiling by Enzyme-Linked Immunoassay

2002 • 69 citations

Nonisotopic Quantitative Analysis of Protein–DNA Interactions at Equilibrium

1997 • 63 citations

The antimitogenic action of tumor necrosis factor is associated with increased AP-1/c-jun proto-oncogene transcription

1989 • 57 citations

Sol Sherry Lecture in Thrombosis

1998 • 52 citations

Modulation of Human Endothelial Cell Tetrahydrobiopterin Synthesis by Activating and Deactivating Cytokines: New Perspectives on Endothelium-Derived Relaxing Factor

1993 • 49 citations

Protegrin-1 increases bacterial clearance in sepsis but decreases survival

2003 • 43 citations

Regulation of 6-Pyruvoyltetrahydropterin Synthase Activity and Messenger RNA Abundance in Human Vascular Endothelial Cells

1998 • 42 citations

Adenovirus-Mediated Overexpression of Dominant-Negative Mutant of c-Jun Prevents Intercellular Adhesion Molecule-1 Induction by LDL

2001 • 35 citations

Effect of tumour necrosis factor, heat, and radiation on the viability and microfilament organization in cultured endothelial cells

1992 • 32 citations

Critical Role of Interleukin-1β for Transcriptional Regulation of Endothelial 6-Pyruvoyltetrahydropterin Synthase

2003 • 25 citations