Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

Thrombin signalling and protease-activated receptors

2000 • 2,383 citations

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

2000 • 1,374 citations

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

1998 • 1,139 citations

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

1987 • 836 citations

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

2001 • 665 citations

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

2000 • 663 citations

Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis

2001 • 655 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

1995 • 380 citations

Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

2001 • 301 citations

The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

2000 • 298 citations

Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.

1994 • 277 citations

MCP-1 protects mice in lethal endotoxemia.

1997 • 262 citations

Protease activated receptors: theme and variations

2001 • 220 citations

Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1

2001 • 185 citations

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates.

1993 • 178 citations

Active Site Inhibited Factor VIIa (DEGR VIIa) Attenuates the Coagulant and Interleukin-6 and -8, but not Tumor Necrosis Factor, Responses of the Baboon to LD100Escherichia coli

1998 • 175 citations

Endothelial Protein C Receptor

1999 • 115 citations

Glycosylation and the activation of proteinase‐activated receptor 2 (PAR₂) by human mast cell tryptase

2001 • 112 citations

Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C Receptor

2001 • 80 citations

Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor‐dependent manner

2000 • 74 citations

Novel Protective Effects of Stem Cell Factor in a Murine Model of Acute Septic Peritonitis

2000 • 30 citations