The Soluble Endothelial Protein C Receptor Binds to Activated Neutrophils: Involvement of Proteinase-3 and CD11b/CD18

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

1990 • 1,214 citations

P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin.

1995 • 712 citations

Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.

1983 • 674 citations

Heptinstall's Pathology of the Kidney

2014 • 622 citations

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

1996 • 524 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

1999 • 346 citations

Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties

1991 • 303 citations

The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

2000 • 298 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Human Protein C Receptor Is Present Primarily on Endothelium of Large Blood Vessels

1997 • 288 citations

Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo

1994 • 285 citations

A novel leukointegrin, αdβ2, binds preferentially to ICAM-3

1995 • 255 citations

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

1990 • 214 citations

Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils.

1997 • 192 citations

Coagulation Activation and Tissue Necrosis in Meningococcal Septic Shock: Severely Reduced Protein C Levels Predict a High Mortality

1995 • 190 citations

Metalloproteolytic Release of Endothelial Cell Protein C Receptor

2000 • 184 citations

Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.

1997 • 178 citations

Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion.

1996 • 172 citations

Plasma Levels of Endothelial Cell Protein C Receptor Are Elevated in Patients With Sepsis and Systemic Lupus Erythematosus: Lack of Correlation With Thrombomodulin Suggests Involvement of Different Pathological Processes

1998 • 172 citations

Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies

1995 • 163 citations

Presence of Proteinase 3 in Secretory Vesicles: Evidence of a Novel, Highly Mobilizable Intracellular Pool Distinct From Azurophil Granules

1999 • 163 citations

Identification of functional endothelial protein C receptor in human plasma.

1997 • 158 citations

The Crystal Structure of PR3, a Neutrophil Serine Proteinase Antigen of Wegener's Granulomatosis Antibodies

1996 • 156 citations

The Endothelial Cell Protein C Receptor

1996 • 152 citations

Treatment of rolling neutrophils with antineutrophil cytoplasmic antibodies causes conversion to firm integrin‐mediated adhesion

2000 • 130 citations

Infectious purpura fulminans: diagnosis and treatment

1999 • 124 citations

Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo

2000 • 122 citations

In Vitro Processing of Human Tumor Necrosis Factor-α

1995 • 114 citations

Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis

1998 • 91 citations

Expression and purification of a soluble tissue factor fusion protein with an epitope for an unusual calcium-dependent antibody

1992 • 89 citations

Divalent cation substitution reveals CD18- and very late antigen-dependent pathways that mediate human neutrophil adherence to fibronectin.

1992 • 88 citations

Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells

1993 • 87 citations

Wegener's granulomatosis: A meta-analysis of 349 literary case reports

1997 • 75 citations

Structure of the Azurocidin, Proteinase 3, and Neutrophil Elastase Genes: Implications for Inflammation and Vasculitis

1994 • 65 citations

A Secreted Proform of Neutrophil Proteinase 3 Regulates the Proliferation of Granulopoietic Progenitor Cells

1999 • 59 citations

Circulating leukocyte integrin expression in Wegener's granulomatosis.

1996 • 47 citations

Wegener autoantigen and myeloblastin are encoded by a single mRNA.

1991 • 44 citations

Antineutrophil cytoplasmic antibodies: Major autoantigens, pathophysiology, and disease associations

1995 • 43 citations

Proteinase 3. A neutrophil proteinase with activity on platelets.

1994 • 43 citations

Membrane Surface Proteinase 3 Expression and Intracytoplasmic Immunoglobulin on Neutrophils from Patients with ANCA-Associated Vasculitides

1993 • 39 citations

Diagnostic value of classical and atypical antineutrophil cytoplasmic antibody (ANCA) immunofluorescence patterns.

1999 • 33 citations

Renal Involvement in Systemic Vasculitis

2001 • 16 citations

Wegener's Granulomatosis

1998 • 15 citations

A Secreted Proform of Neutrophil Proteinase 3 Regulates the Proliferation of Granulopoietic Progenitor Cells

1999 • 7 citations

Anti-neutrophil Cytoplasmic Antibody-Enriched IgG Induces Adhesion of Human T Lymphocytes to Extracellular Matrix Proteins

1997 • 6 citations