Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase‐3β

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Mechanisms of angiogenesis and arteriogenesis

2000 • 4,120 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

Angiopoietin-1 protects the adult vasculature against plasma leakage

2000 • 1,271 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Cytoskeletal regulation of pulmonary vascular permeability

2001 • 954 citations

Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling

1993 • 877 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

A morphological biosensor for mammalian cells

1993 • 756 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Emerging Multipotent Aspects of Hepatocyte Growth Factor

1996 • 662 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function.

1992 • 424 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease

2000 • 394 citations

Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

2000 • 386 citations

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses

2000 • 333 citations

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1997 • 276 citations

Activation of Cdc42, Rac, PAK, and Rho-Kinase in Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation

2000 • 276 citations

Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation

2000 • 258 citations

Essential Role of Gab1 for Signaling by the C-Met Receptor in Vivo

2000 • 255 citations

Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury.

1993 • 253 citations

Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript

1991 • 224 citations

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

1992 • 222 citations

Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium.

1994 • 209 citations

WNT-1 and HGF Regulate GSK3β Activity and β-Catenin Signaling in Mammary Epithelial Cells

1998 • 187 citations

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

1995 • 180 citations

Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356

1997 • 165 citations

Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.

1993 • 159 citations

Differential Regulation of Sphingosine-1-Phosphate- and VEGF-Induced Endothelial Cell Chemotaxis

2001 • 144 citations

Regulation of Complexed and Free Catenin Pools by Distinct Mechanisms

1997 • 138 citations

Enhancement of Migration by Protein Kinase Cα and Inhibition of Proliferation and Cell Cycle Progression by Protein Kinase Cδ in Capillary Endothelial Cells

1997 • 134 citations

Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

1994 • 130 citations

Association of the HGF/SF Receptor, c-met, with the Cell-Surface Adhesion Molecule, E-Cadherin, and Catenins in Human Tumor Cells

1999 • 119 citations

Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells

1999 • 101 citations

Role of Ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction

2000 • 93 citations

Scatter Factor and Angiogenesis

1995 • 89 citations

Cooperative Interaction between α- and β-Chains of Hepatocyte Growth Factor on c-Met Receptor Confers Ligand-induced Receptor Tyrosine Phosphorylation and Multiple Biological Responses

1998 • 89 citations

Differential signaling by alternative HGF isoforms through c-Met: activation of both MAP kinase and PI 3-kinase pathways is insufficient for mitogenesis

1999 • 80 citations

HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line

2001 • 78 citations

Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinositol-3 kinase/Akt pathway

2000 • 76 citations

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation

1997 • 76 citations

Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation

2000 • 76 citations

Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II

2001 • 70 citations

Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus.

1995 • 68 citations

Sustained Activation of Extracellular Signal-regulated Kinase Stimulated by Hepatocyte Growth Factor Leads to Integrin α2 Expression That Is Involved in Cell Scattering

2001 • 57 citations

Functional and biophysical characterization of recombinant human hepatocyte growth factor isoforms produced in Escherichia coli

1997 • 55 citations

Cell adhesion to tenascin‐X

1999 • 52 citations

Dual Effects of PKNα and Protein Kinase C on Phosphorylation of Tau Protein by Glycogen Synthase Kinase-3β

2000 • 51 citations

Receptor tyrosine kinase signaling in vascular development.

1997 • 36 citations

HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells

2001 • 34 citations

Selective Activation of Phospholipase Cγ1 and Distinct Protein Kinase C Subspecies in Intracellular Signaling by Hepatocyte Growth Factor/Scatter Factor in Primary Cultured Rat Neocortical Cells

1998 • 28 citations

Interferon- γ Upregulates the c-Met/Hepatocyte Growth Factor Receptor Expression in Alveolar Epithelial Cells

1999 • 27 citations

Intercellular Junctions in the Endothelium and the Control of Vascular Permeability

1997 • 27 citations

Glioma Inhibition by HGF/NK2, an Antagonist of Scatter Factor/Hepatocyte Growth Factor

2000 • 26 citations

Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro

1997 • 21 citations