Role of Ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Glucosylation of Rho proteins by Clostridium difficile toxin B

1995 • 1,025 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 • 550 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation.

1995 • 451 citations

Caldesmon, a novel regulatory protein in smooth muscle and nonmuscle actomyosin systems

1991 • 353 citations

Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins

1998 • 320 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function

1998 • 238 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

The molecular anatomy of caldesmon

1991 • 224 citations

High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα

1997 • 206 citations

cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation

1997 • 200 citations

Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium.

1990 • 196 citations

Inactivation of Ras by Clostridium sordellii Lethal Toxin-catalyzed Glucosylation

1996 • 190 citations

Bacterial toxins that target Rho proteins.

1997 • 176 citations

Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during mitosis

1991 • 171 citations

Regulation of endothelial cell gap formation and paracellular permeability.

1995 • 165 citations

Phosphorylation of caldesmon in arterial smooth muscle

1989 • 165 citations

Protein kinase C phosphorylates caldesmon₇₇ and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1992 • 163 citations

Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.

1993 • 159 citations

A role for MAP kinase in differentiated smooth muscle contraction evoked by α-adrenoceptor stimulation

1998 • 157 citations

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60^src

1999 • 157 citations

Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts

1990 • 153 citations

Regulation of permeabilized endothelial cell retraction by myosin phosphorylation

1991 • 149 citations

Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells.

1997 • 149 citations

Structure and function of the endothelial cytoskeleton.

1991 • 136 citations

Clostridium botulinum C3 ADP-Ribosyltransferase

1992 • 136 citations

Identification of mitogen‐activated protein kinase phosphorylation sequences in mammalian h‐Caldesmon

1993 • 136 citations

Differential detergent fractionation of isolated hepatocytes: Biochemical, immunochemical and two‐dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments

1994 • 128 citations

Regulation of Thrombin-Mediated Endothelial Cell Contraction and Permeability

1996 • 121 citations

Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle.

1996 • 103 citations

Signal transduction pathways involving the raf proto-oncogene

1994 • 99 citations

Mechanisms of ionomycin-induced endothelial cell barrier dysfunction

1997 • 98 citations

Phosphorylation sequences in h‐caldesmon from phorbol ester‐stimulated canine aortas

1992 • 89 citations

Protein Serine/Threonine Kinases of the MAPK Cascade

1995 • 86 citations

Myosin phosphorylation-independent contraction induced by phorbol ester in vascular smooth muscle.

1992 • 81 citations

Mechanisms of Cholera Toxin Prevention of Thrombin- and PMA-Induced Endothelial Cell Barrier Dysfunction

1994 • 78 citations

Phosphorylation of caldesmon by mitogen‐activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.

1995 • 77 citations

Potent, Cell Active, Non-Thiol Tetrapeptide Inhibitors of Farnesyltransferase

1996 • 77 citations

Mechanisms regulating Raf‐1 activity in signal transduction pathways

1995 • 75 citations

Activation of MAP kinases in airway smooth muscle

1997 • 73 citations

Rho Protein Inhibition Blocks Protein Kinase C Translocation and Activation

1998 • 68 citations

Phosphorylation of caldesmon by cdc2 kinase.

1991 • 63 citations

Caidesmon and calponin phosphorylation in regulation of smooth muscle contraction

1994 • 60 citations

Role of Tyrosine Phosphorylation in Thrombin-Induced Endothelial Cell Contraction and Barrier Function

1998 • 58 citations

Phosphorylation of caldesmon77 by protein kinase C in vitro and in intact human platelets.

1987 • 47 citations

Protein kinase C β modulates thrombin-induced Ca2+ signaling and endothelial permeability increase

1998 • 43 citations

Kinase activation and smooth muscle contraction in the presence and absence of calcium

1995 • 39 citations

Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts.

1995 • 39 citations

Protein Kinase C Activation during Ca2+-Independent Vascular Smooth Muscle Contraction

1998 • 38 citations

Characterization of the COOH Terminus of Non-muscle Caldesmon Mutants Lacking Mitosis-specific Phosphorylation Sites

1995 • 37 citations

Resting Distribution and Stimulated Translocation of Protein Kinase C Isoforms Alpha, Epsilon and Zeta in Response to Bradykinin and TNF in Human Endothelial Cells

1997 • 37 citations

The Ca2+-Sensitizing Component of Smooth Muscle Thin Filaments: Properties of Regulatory Factors That Interact with Caldesmon

1993 • 19 citations

Receptors for the Phorbol Promoters Ester Tumour

1985 • 8 citations