Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle

2000 • 599 citations

Activation of RhoA by Thrombin in Endothelial Hyperpermeability

2000 • 402 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Thrombin Inactivates Myosin Light Chain Phosphatase via Rho and Its Target Rho Kinase in Human Endothelial Cells

1998 • 348 citations

The Role of the Microtubules in Tumor Necrosis Factor-α–Induced Endothelial Cell Permeability

2003 • 316 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.

1994 • 199 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Regulation of permeabilized endothelial cell retraction by myosin phosphorylation

1991 • 149 citations

Rho activation in excitatory agonist-stimulated vascular smooth muscle

2001 • 146 citations

Activation of Myosin Light Chain Phosphatase in Intact Arterial Smooth Muscle During Nitric Oxide-induced Relaxation

2001 • 131 citations

Neutrophil Apoptosis during the Development and Resolution of Oleic Acid-Induced Acute Lung Injury in the Rat

1998 • 101 citations

THE MODERN VERSION OF ADULT RESPIRATORY DISTRESS SYNDROME

1995 • 98 citations

Lung function, permeability, and surfactant composition in oleic acid-induced acute lung injury in rats

2000 • 83 citations

Oleic Acid–Induced Mitogenic Signaling in Vascular Smooth Muscle Cells

1996 • 82 citations

Phospholipase D Activation by Sphingosine 1-Phosphate Regulates Interleukin-8 Secretion in Human Bronchial Epithelial Cells

2002 • 81 citations

Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster

1999 • 80 citations

Oleic-acid-induced lung injury in the rat. Failure of indomethacin treatment or complement depletion to ablate lung injury.

1981 • 72 citations

Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability

2004 • 72 citations

Pathogenesis of oleic acid‐induced lung injury in the rat: Distribution of oleic acid during injury and early endothelial cell changes

1995 • 68 citations

Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells

2001 • 53 citations

Expression of Rho‐kinase and its functional role in the contractile activity of the mouse vas deferens

2003 • 52 citations

Mechanisms of NOS2 regulation by Rho GTPase signaling in airway epithelial cells

2002 • 50 citations

Oleic acid induces endothelin-1 expression through activation of protein kinase C and NF-κB

2003 • 49 citations

Bombesin stimulates invasion and migration of Isreco1 colon carcinoma cells in a Rho-dependent manner.

2002 • 45 citations

Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus

2003 • 42 citations

Virulent and avirulent strains of equine arteritis virus induce different quantities of TNF-α and other proinflammatory cytokines in alveolar and blood-derived equine macrophages

2003 • 40 citations

Activation of polymorphonuclear leukocytes in oleic acid-induced lung injury

1998 • 39 citations

Nitric oxide and cell respiration: physiology and pathology.

2000 • 35 citations

Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs

2004 • 29 citations

Role of inducible nitric oxide synthase-derived nitric oxide in lipopolysaccharide plus interferon-γ-induced pulmonary inflammation

2003 • 28 citations

Preventive Effect of Phosphoenolpyruvate on Hypoxemia Induced by Oleic Acid in Guinea Pigs.

2003 • 13 citations