Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

1997 • 1,162 citations

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

1994 • 858 citations

VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells

1998 • 694 citations

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

1997 • 665 citations

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

1996 • 567 citations

Regulation of vascular endothelial barrier function

1994 • 481 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells

1997 • 436 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor Augments Nitric Oxide Release From Quiescent Rabbit and Human Vascular Endothelium

1997 • 406 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells.

1991 • 325 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

VEGF induces NO-dependent hyperpermeability in coronary venules

1996 • 247 citations

Ca2+calmodulin-regulated nitric oxide synthases

1992 • 194 citations

Calcium measurement in isolated arterioles during myogenic and agonist stimulation

1991 • 178 citations

Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade

1993 • 174 citations

Role of VEGF receptor-1 (Flt-1) in mediating calcium-dependent nitric oxide release and limiting DNA synthesis in human trophoblast cells.

1997 • 156 citations

Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway

1997 • 150 citations

Modulation of venular microvessel permeability by calcium influx into endothelial cells

1992 • 138 citations

Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability

1997 • 112 citations

Role of protein kinase C in bradykinin-induced increases in microvascular permeability.

1991 • 99 citations

Permeability to albumin in isolated coronary venules

1993 • 66 citations

Cytosolic calcium changes in endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity

1989 • 61 citations

Protein kinase C modulates microvascular permeability through nitric oxide synthase

1996 • 56 citations

Simultaneous activation of adenylyl cyclase and protein kinase C induces production of nitric oxide by vascular smooth muscle cells.

1994 • 52 citations

PKC mediates LPS- and phorbol-induced cardiac cell nitric oxide synthase activity and hypocontractility

1995 • 43 citations

Role of nitric oxide, prostaglandins and tyrosine kinase in vascular endothelial growth factor-induced increase in vascular permeability in mouse skin

1997 • 42 citations

Vascular endothelial growth factor, a multifunctional polypeptide.

1996 • 32 citations

Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C

1994 • 31 citations

Altered basal and adenosine‐mediated protein flux from coronary arterioles isolated from exercise‐trained pigs

1997 • 22 citations