Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

2005 • 2,075 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

PipMaker—A Web Server for Aligning Two Genomic DNA Sequences

2000 • 1,194 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

1982 • 877 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

Activation‐induced cell death in T cells

2003 • 613 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

M<scp>olecular</scp>D<scp>efects in</scp>H<scp>uman</scp>S<scp>evere</scp>C<scp>ombined</scp>I<scp>mmunodeficiency and</scp>A<scp>pproaches to</scp>I<scp>mmune</scp>R<scp>econstitution</scp>

2004 • 524 citations

SATB1 targets chromatin remodelling to regulate genes over long distances

2002 • 485 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

2003 • 458 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

The IL-2 Receptor β Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities

1987 • 444 citations

Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ _c Receptors

2005 • 434 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

1997 • 402 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development

2000 • 391 citations

Cytokines and immunodeficiency diseases

2001 • 380 citations

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

2000 • 374 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Stabilization of Interleukin-2 mRNA by the c-Jun NH ₂ -Terminal Kinase Pathway

1998 • 353 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

1994 • 338 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

Signaling routes to CREM and CREB: plasticity in transcriptional activation

1999 • 304 citations

Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation

1998 • 304 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

1998 • 287 citations

Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells

1999 • 273 citations

Novel NFAT Sites That Mediate Activation of the Interleukin-2 Promoter in Response to T-Cell Receptor Stimulation

1995 • 259 citations

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor

2006 • 254 citations

Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors.

1987 • 252 citations

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

1996 • 249 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

Monoallelic Expression of the Interleukin-2 Locus

1998 • 232 citations

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

1997 • 224 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

The Significance of Tetramerization in Promoter Recruitment by Stat5

1999 • 213 citations

The state of the STATs: recent developments in the study of signal transduction to the nucleus

1997 • 212 citations

Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications

2004 • 208 citations

Identification of a Zinc Finger Protein that Inhibits IL-2 Gene Expression

1991 • 195 citations

Functionally Distinct NF-κB Binding Sites in the Immunoglobulin κ and IL-2 Receptor α Chain Genes

1989 • 194 citations

A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.

1996 • 182 citations

Analysis of the AP-1 sites in the IL-2 promoter.

1992 • 179 citations

A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory

2006 • 175 citations

The Common Cytokine Receptor γ Chain Plays an Essential Role in Regulating Lymphoid Homeostasis

1997 • 168 citations

THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling

1996 • 168 citations

IL-2 Secretion by CD4+ T Cells In Vivo Is Rapid, Transient, and Influenced by TCR-Specific Competition

2004 • 166 citations

Signaling from the IL-2 receptor to the nucleus

1997 • 157 citations

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

1996 • 152 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation

2001 • 152 citations

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1

1995 • 150 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation

2002 • 137 citations

Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1.

1992 • 131 citations

The −180 Site of the IL-2 Promoter Is the Target of CREB/CREM Binding in T Cell Anergy

1999 • 127 citations

Characterization of a mouse multigene family that encodes zinc finger structures.

1988 • 127 citations

Signals from CD28 Induce Stable Epigenetic Modification of the IL-2 Promoter

2005 • 125 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1996 • 117 citations

Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation.

1992 • 115 citations

NEW EMBO MEMBER'S REVIEW: Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity

2003 • 111 citations

High Mobility Group Protein I(Y) Is Required for Function and for c-Rel Binding to CD28 Response Elements within the GM-CSF and IL-2 Promoters

1996 • 109 citations

Expression of the IL-2 receptor γ chain on various populations in human peripheral blood

1994 • 104 citations

Synergistic Activation of CD4+ T Cells by IL-16 and IL-2

1998 • 100 citations

Mice with a Fluorescent Marker for Interleukin 2 Gene Activation

1998 • 100 citations

Defective expression of the interleukin-2/interleukin-15 receptor β subunit leads to a natural killer cell–deficient form of severe combined immunodeficiency

2001 • 100 citations

Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2.

1993 • 97 citations

Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.

1994 • 90 citations

Antisense Cyclic Adenosine 5′-Monophosphate Response Element Modulator Up-Regulates IL-2 in T Cells from Patients with Systemic Lupus Erythematosus

2002 • 89 citations

Characterization of the human interleukin-2 receptor gamma chain gene

1993 • 88 citations

The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death.

1999 • 87 citations

Chromatin remodeling of the interleukin-2 gene: Distinct alterations in the proximal versus distal enhancer regions

1998 • 87 citations

The Immediate-Early Gene Product Egr-1 Regulates the Human Interleukin-2 Receptor β-Chain Promoter through Noncanonical Egr and Sp1 Binding Sites

1997 • 86 citations

Calcium-dependent Activation of Interleukin-21 Gene Expression in T Cells

2005 • 84 citations

The Early Growth Response Protein (EGR-1) Regulates Interleukin-2 Transcription by Synergistic Interaction with the Nuclear Factor of Activated T Cells

1998 • 83 citations

Displacement of SATB1-Bound Histone Deacetylase 1 Corepressor by the Human Immunodeficiency Virus Type 1 Transactivator Induces Expression of Interleukin-2 and Its Receptor in T Cells

2005 • 77 citations

The Interleukin 2 Receptor α Chain/CD25 Promoter Is a Target for Nuclear Factor of Activated T Cells

1998 • 77 citations

Functional cleavage of the common cytokine receptor γ chain (γ_c) by calpain

1997 • 75 citations

The Cyclic Adenosine 5′-Monophosphate Response Element Modulator Suppresses IL-2 Production in Stimulated T Cells by a Chromatin-Dependent Mechanism

2003 • 74 citations

Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.

1993 • 73 citations

A New Regulatory Region of the IL-2 Locus That Confers Position-Independent Transgene Expression

2001 • 73 citations

The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements

2002 • 72 citations

Early immune response and regulation of IL-2 receptor subunits

2005 • 71 citations

The same 50-kDa cellular protein binds to the negative regulatory elements of the interleukin 2 receptor alpha-chain gene and the human immunodeficiency virus type 1 long terminal repeat.

1989 • 67 citations

The Role of the Common Cytokine Receptor γ-Chain in Regulating IL-2-Dependent, Activation-Induced CD8+ T Cell Death

1999 • 67 citations

The GABP-responsive Element of the Interleukin-2 Enhancer Is Regulated by JNK/SAPK-activating Pathways in T Lymphocytes

1998 • 66 citations

Transcriptional Repression of the IL-2 Gene in Th Cells by ZEB

1998 • 66 citations

Negative transcriptional regulation in anergic T cells.

1995 • 66 citations

CD28 costimulation up-regulates long-term IL-2R beta expression in human T cells through combined transcriptional and post-transcriptional regulation.

1995 • 61 citations

Binding of HMG-I(Y) Imparts Architectural Specificity to a Positioned Nucleosome on the Promoter of the Human Interleukin-2 Receptor α Gene

2000 • 59 citations

Regulation by interleukin-2 (IL-2) and interferon gamma of IL-2 receptor gamma chain gene expression in human monocytes

1994 • 58 citations

CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes.

1997 • 57 citations

The Human IL-2 Gene Promoter Can Assemble a Positioned Nucleosome That Becomes Remodeled Upon T Cell Activation

2002 • 54 citations

Expression of the mouse interleukin‐2 receptor γ chain in various cell populations of the thymus and spleen

1994 • 54 citations

A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.

1990 • 53 citations

GABP Factors Bind to a Distal Interleukin 2 (IL-2) Enhancer and Contribute to c-Raf-Mediated Increase in IL-2 Induction

1997 • 52 citations

IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells

2000 • 51 citations

In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells.

1995 • 51 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation: Importance of Two Widely Separated IL-2 Response Elements

2001 • 49 citations

Induction of the interleukin-2/15 receptor β-chain by the EWS–WT1 translocation product

2002 • 45 citations

Smad-dependent Cooperative Regulation of Interleukin 2 Receptor α Chain Gene Expression by T Cell Receptor and Transforming Growth Factor-β

2005 • 43 citations

Elf-1 Contributes to the Function of the Complex Interleukin (IL)-2–responsive Enhancer in the Mouse IL-2 Receptor α Gene

1997 • 41 citations

CD28-Mediated Regulation of mRNA Stability Requires Sequences Within the Coding Region of the IL-2 mRNA

1999 • 40 citations

Temporal and Subunit-specific Modulations of the Rel/NF-κB Transcription Factors Through CD28 Costimulation

1997 • 37 citations

Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes. Autocrine role of tumor necrosis factor alpha.

1994 • 37 citations

Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.

1990 • 37 citations

In utero treatment with monoclonal antibody to IL-2 receptor β-chain completely abrogates development of Thy-1⁺ dendritic epidermal cells

1992 • 36 citations

Functional Analysis of the Human Interleukin 2 Receptor γ Chain Gene Promoter

1995 • 36 citations

IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice

1994 • 35 citations

Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor α-Chain Locus

2001 • 33 citations

The potential role of interleukin-2 in patients with HIV infection.

2002 • 30 citations

Tissue-specific Activity of the γc Chain Gene Promoter Depends upon an Ets Binding Site and Is Regulated by GA-binding Protein

1996 • 25 citations

IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes.

1992 • 25 citations

Retinoid Regulation of Interleukin-2 Receptors on Human T-Cells

1997 • 23 citations

Sp1 represses IL-2 receptor alpha chain gene expression.

1990 • 22 citations

Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor α Gene to Transcription Factors

1999 • 21 citations

Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development

2002 • 21 citations

Biallelic expression of the IL‐2 locus under optimal stimulation conditions

2000 • 19 citations

The Destabilization of IL-2 mRNA by a Premature Stop Codon and Its Differential Stabilization byTrans-Acting Inhibitors of Protein Synthesis Do Not Support a Role for Active Translation in mRNA Stability

1999 • 19 citations

IL-2 receptor alpha-chain expression is independently regulated in primary and secondary lymphoid organs.

1998 • 17 citations

Biallelic expression of the IL-2 locus under optimal stimulation conditions

2000 • 14 citations

IL-2 Receptor α-Chain Expression Is Independently Regulated in Primary and Secondary Lymphoid Organs

1998 • 13 citations

IDENTIFICATION OF A NOVEL GLUCOCORTICOID RESPONSE UNIT (GRU) IN THE 5′-FLANKING REGION OF THE MOUSE IL-2 RECEPTOR α GENE

1997 • 11 citations

Inhibition of IL-2 production by Nil-2-a in murine T cells

1998 • 8 citations

A negative regulatory element-dependent inhibitory role of ITF2B on IL-2 receptor α gene

2005 • 7 citations

NEGATIVE REGULATION OF THE INTERLEUKIN (IL)-2 RECEPTOR α CHAIN (CD25) PROMOTER REGION IN HUMAN B LYMPHOCYTES

1997 • 5 citations

Mechanisms and Biological Consequences of STAT Signaling by Cytokines that Share the Common Cytokine Receptor γ Chain, γc

2003 • 3 citations