Monoallelic Expression of the Interleukin-2 Locus

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Allelic inactivation regulates olfactory receptor gene expression

1994 • 1,056 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line

1988 • 550 citations

Asynchronous Duplication of Chromosomes in Cultured Cells of Chinese Hamster

1960 • 530 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

V(D)J Recombination: Molecular Biology and Regulation

1992 • 464 citations

Allele-specific replication timing of imprinted gene regions

1993 • 385 citations

Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells.

1984 • 272 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Role of replication time in the control of tissue-specific gene expression.

1987 • 249 citations

The ups and downs of T cell costimulation

1994 • 240 citations

Allele specificity of DNA replication timing in the Angelman/Prader–Willi syndrome imprinted chromosomal region

1994 • 195 citations

Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

1994 • 176 citations

Mechanism of Interleukin-2 Signaling: Mediation of Different Outcomes by a Single Receptor and Transduction Pathway

1989 • 148 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

Interleukin-2 Transcription Is Regulated In Vivo at the Level of Coordinated Binding of Both Constitutive and Regulated Factors

1994 • 138 citations

T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.

1984 • 113 citations

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

1989 • 100 citations

Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects

1994 • 93 citations

Adhesion receptors in lymphocyte activation

1994 • 90 citations

Molecular Analysis of the Interleukin‐2 System

1986 • 89 citations

An Immunodeficiency Characterized by Defective Signal Transduction in T Lymphocytes

1989 • 88 citations

Organization and structure of the mouse interleukin-2 gene

1984 • 83 citations

Relationship between IL 2 synthesis and the proliferative response to PHA in different primary immunodeficiencies.

1982 • 82 citations

Interleukin 2 abrogates the nonresponsive state of T cells expressing a forbidden T cell receptor repertoire and induces autoimmune disease in neonatally thymectomized mice.

1991 • 81 citations

Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells.

1990 • 78 citations

Analysis of IL-2, IL-4, and IFN-gamma-producing cells in situ during immune responses to protein antigens.

1993 • 77 citations

Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.

1985 • 72 citations

Thymic selection and peptide‐induced activation of T cell receptor‐transgenic CD8 T cells in interleukin‐2‐deficient mice

1994 • 64 citations

Allele-specific gene expression in mammals: the curious case of the imprinted RNAs.

1994 • 56 citations

In vivo administration of interleukin‐2 turns on anergic self‐reactive T cells and leads to autoimmune disease

1992 • 44 citations

Impaired production of interleukins in patients with cell-mediated immunodeficiencies.

1983 • 38 citations

Possible role of IL-2 deficiency for hypogammaglobulinaemia in patients with common variable immunodeficiency

1992 • 33 citations

Limiting Dilution Analysis of Interleukin 2‐Producing Mature T Cells

1988 • 27 citations

Cryptococcal osteomyelitis and cellular immunodeficiency associated with interleukin-2 deficiency

1992 • 27 citations

Mapping the gene for murine T-cell growth factor, <i>Il-</i><i>2</i> to bands B-C on Chromosome 3 and for the α chain of the IL2-receptor, <i>Il-2r</i><i>a</i>, to bands A2–A3 on Chromosome 2

1990 • 20 citations

Lymphocytes with a CD4+ CD8- CD3- phenotype are effectors of experimental cutaneous graft-versus-host disease.

1991 • 17 citations

Glutamine and tetrapeptide repeat variations affect the biological activity of different mouse interleukin‐2 alleles

1996 • 16 citations

Assignment of the interleukin-2 locus to mouse chromosome 3

1989 • 14 citations

Existence of at least five interleukin-2 molecules in different mouse strains

1993 • 13 citations

EXOGENOUS RECOMBINANT INTERLEUKIN-2 ABROGATES ANTERIOR-CHAMBER-ASSOCIATED IMMUNE DEVIATION

1987 • 13 citations

Selective deficiency in IL-2 production and refractoriness to extrinsic IL-2 in immunodeficiency with hyper-IgM

1987 • 8 citations