A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Control points in early T-cell development

1993 • 429 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins

1995 • 374 citations

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1990 • 353 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative

1995 • 310 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Novel NFAT Sites That Mediate Activation of the Interleukin-2 Promoter in Response to T-Cell Receptor Stimulation

1995 • 259 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

1992 • 246 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

Effects of different DNA polymerases in ligation-mediated PCR: enhanced genomic sequencing and in vivo footprinting.

1992 • 232 citations

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

1995 • 229 citations

A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region.

1996 • 220 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells Family That Is Expressed Predominantly in the Thymus

1995 • 211 citations

RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.

1995 • 198 citations

Identification of a Zinc Finger Protein that Inhibits IL-2 Gene Expression

1991 • 195 citations

Nucleosome positioning and modification: chromatin structures that potentiate transcription

1994 • 182 citations

Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.

1988 • 176 citations

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.

1986 • 171 citations

The Development of Functionally Responsive T Cells

1992 • 169 citations

NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity

1995 • 168 citations

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.

1994 • 166 citations

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor.

1992 • 164 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Architectural variations of inducible eukaryotic promoters: Preset and remodeling chromatin structures

1994 • 160 citations

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1

1995 • 150 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

Interleukin-2 Transcription Is Regulated In Vivo at the Level of Coordinated Binding of Both Constitutive and Regulated Factors

1994 • 138 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes.

1993 • 129 citations

Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system.

1994 • 123 citations

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.

1996 • 113 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Regulatory anatomy of the murine interleukin-2 gene

1990 • 106 citations

The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

1991 • 99 citations

Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model.

1996 • 99 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

Regulation of Interleukin 2 Gene Expression by CD28 Costimulation in Mouse T-Cell Clones: both Nuclear and Cytoplasmic RNAs Are Regulated with Complex Kinetics

1995 • 92 citations

The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.

1990 • 91 citations

An Enhancer/Locus Control Region Is Not Sufficient To Open Chromatin

1993 • 90 citations

Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.

1994 • 90 citations

In situ hybridization for interleukin 2 and interleukin 2 receptor mRNA in T cells activated in the presence or absence of cyclosporin A.

1988 • 86 citations

Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

1995 • 84 citations

Regulation of AP-1 and NFAT Transcription Factors during Thymic Selection of T Cells

1996 • 74 citations

Promoter Region of Interleukin-2 Gene Undergoes Chromatin Structure Changes and Confers Inducibility on Chloramphenicol Acetyltransferase Gene During Activation of T Cells

1986 • 67 citations

cis-Acting Sequences Required for Inducible Interleukin-2 Enhancer Function Bind a Novel Ets-Related Protein, Elf-1

1992 • 66 citations

The weak, fine-tuned binding of ubiquitous transcription factors to the II-2 enhancer contributes to its T cell-restricted activity

1992 • 62 citations

Expression and induction of nuclear factor-kappa B-related proteins in thymocytes.

1995 • 62 citations

Multiple modes of dorsal-bHLH transcriptional synergy in the Drosophila embryo.

1995 • 60 citations

Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene.

1988 • 53 citations

In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells.

1995 • 51 citations

Interleukin-1 synergy with phosphoinositide pathway agonists for induction of interleukin-2 gene expression: molecular basis of costimulation.

1990 • 48 citations

IL-2 gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation.

1990 • 48 citations

Regulation of the Interleukin-2 Gene

2015 • 47 citations

The selective ablation of interleukin 2-producing cells isolated from transgenic mice.

1993 • 46 citations

Role of ETS1 in IL-2 gene expression.

1995 • 40 citations

IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice

1994 • 35 citations

Dual promoter activation by the human beta-globinlocus control region.

1994 • 35 citations

Interleukin 2, 4 and 5 are sequentially produced in mitogen‐stimulated murine spleen cell cultures

1990 • 35 citations

Regulated expression and function of CD122 (interleukin-2/interleukin- 15R-beta) during lymphoid development

1996 • 33 citations

Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point.

1993 • 32 citations

The Promoter of the Human Interleukin-2 Gene Contains Two Octamer-Binding Sites and Is Partially Activated by the Expression of Oct-2

1990 • 31 citations

In vivofootprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T cells

1993 • 31 citations

Molecular Basis for Developmental Changes in Interleukin-2 Gene Inducibility

1993 • 30 citations

Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug- treated naive and memory T-helper cells

1994 • 24 citations

Transcription factor‐mediated chromatin remodelling: mechanisms and models

1995 • 18 citations

Developmental and Anatomical Patterns Of IL-2 Gene Expressionin Vivoin The Murine Thymus

1992 • 17 citations

Interleukin-1 Synergy with Phosphoinositide Pathway Agonists for Induction of Interleukin-2 Gene Expression: Molecular Basis of Costimulation

1990 • 11 citations

Regulation of IL2 gene transcription via the T-cell accessory molecule CD28

1995 • 9 citations

Programming for recognition and programming for response. Separate developmental subroutines in the murine thymus.

1994 • 7 citations

Interleukin 1 activation of the AP-1 transcription complex in murine T cells is regulated at the level of Jun B protein accumulation

1995 • 4 citations