Antisense Cyclic Adenosine 5′-Monophosphate Response Element Modulator Up-Regulates IL-2 in T Cells from Patients with Systemic Lupus Erythematosus

Derivation of the sledai. A disease activity index for lupus patients

1992 • 4,410 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Transcription Factors Responsive to cAMP

1995 • 379 citations

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

1996 • 249 citations

Transcriptional regulation by cyclic AMP-responsive factors

2000 • 228 citations

Molecular Basis of Deficient IL-2 Production in T Cells from Patients with Systemic Lupus Erythematosus

2001 • 193 citations

T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?

1993 • 183 citations

A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.

1996 • 182 citations

Immune effects and mechanisms of action of CpG motifs

2000 • 179 citations

Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression.

1999 • 144 citations

The −180 Site of the IL-2 Promoter Is the Target of CREB/CREM Binding in T Cell Anergy

1999 • 127 citations

Abnormal NF-κB Activity in T Lymphocytes from Patients with Systemic Lupus Erythematosus Is Associated with Decreased p65-RelA Protein Expression

1999 • 111 citations

Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression.

1991 • 108 citations

Defective CD3-Mediated Cell Death in Activated T Cells from Patients with Systemic Lupus Erythematosus: Role of Decreased Intracellular TNF-α

1996 • 106 citations

The T cell enigma in lupus

1996 • 106 citations

Adaptive inducibility of CREM as transcriptional memory of circadian rhythms

1996 • 88 citations

T cell-antigen-presenting cell interactions in human systemic lupus erythematosus. Evidence for heterogeneous expression of multiple defects.

1993 • 73 citations

Increased Expression of Functional Fas-Ligand in Activated T Cells from Patients with Systemic Lupus Erythematosus

1997 • 68 citations

Immune cell signaling in lupus

2000 • 67 citations

Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER)

2001 • 66 citations

Suppression of T cell function: a potential role for transcriptional repressor ICER

2000 • 63 citations

Protein Kinase C-θ Participates in the Activation of Cyclic AMP-Responsive Element-Binding Protein and Its Subsequent Binding to the −180 Site of the IL-2 Promoter in Normal Human T Lymphocytes

2001 • 58 citations

The biological treatment of renal-cell carcinoma and melanoma

2002 • 56 citations

Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients

1996 • 54 citations

Dominant Expression of a Novel Splice Variant of Caspase-8 in Human Peripheral Blood Lymphocytes

2000 • 49 citations

Human RNA Helicase A Is a Lupus Autoantigen That Is Cleaved During Apoptosis

1999 • 47 citations

Novel Cyclic Adenosine 3′,5′-Monophosphate (cAMP) Response Element Modulator θ Isoforms Expressed by Two Newly Identified cAMP-Responsive Promoters Active in the Testis¹

2000 • 44 citations

Cross-talk in signal transduction: Ras-dependent induction of cAMP-responsive transcriptional repressor ICER by nerve growth factor

1997 • 43 citations

Interleukin-2 and human immunodeficiency virus infection: Pathogenic mechanisms and potential for immunologic enhancement

1996 • 42 citations

Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells.

2000 • 42 citations

Protein Kinase A RIβ Subunit Deficiency in Lupus T Lymphocytes: Bypassing a Block in RIβ Translation Reconstitutes Protein Kinase A Activity and Augments IL-2 Production

2001 • 41 citations

The potential role of interleukin-2 in HIV

2001 • 36 citations

Increased expression of c-rel, from the NF-kappaB/Rel family, in T cells from patients with systemic lupus erythematosus.

2000 • 33 citations

Differential Oncogene and TNF‐α mRNA Expression in Bone Marrow Cells from Systemic Lupus Erythematosus Patients

1998 • 28 citations

Improving DNA Vaccines Targeting Viral Infection

2000 • 19 citations

The Effect of Circulating Serum Factors from Patients with Systemic Lupus Erythematosus on Protein Kinase A (PKA) Activity and PKA-Dependent Protein Phosphorylation in T Lymphocytes

1993 • 15 citations

Interleukin-2 as a therapeutic agent.

2001 • 14 citations