c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

Future influenza vaccines and the use of genetic recombinants.

1969 • 386 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1999 • 364 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

2001 • 349 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH ₂ -terminal kinase activation, and defects in AP-1 transcriptional activity

1997 • 266 citations

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

1993 • 265 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

1998 • 217 citations

Requirement for Transcription Factor NFAT in Interleukin-2 Expression

1999 • 196 citations

Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon γ Production from CD4+ Versus CD8+ T Cells

1999 • 168 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

Prostaglandin E₂ and the increase of intracellular cAMP inhibit the expression of interleukin 2 receptors in human T cells

1988 • 129 citations

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

1997 • 128 citations

Reprogramming the signalling requirement for AP‐1 (activator protein‐1) activation during differentiation of precursor CD4⁺ T‐cells into effector Th1 and Th2 cells

1997 • 115 citations

Integration of Calcium and Cyclic AMP Signaling Pathways by 14-3-3

2000 • 109 citations

Activation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8⁺ but Not CD4⁺ T Cells

2000 • 98 citations

Granulysin: a lethal weapon of cytolytic T cells

1999 • 97 citations

Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection

2000 • 96 citations

Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation

2000 • 93 citations

Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)

2001 • 87 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity

2002 • 85 citations

Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.

1992 • 80 citations

SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development

1998 • 67 citations

JNK1 Is Required for T Cell-Mediated Immunity AgainstLeishmania majorInfection

2000 • 66 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells

2001 • 61 citations

Blockade of CD28/B7 co‐stimulation by mCTLA4‐Hγ1 inhibits antigen‐induced lung eosinophilia but not Th2 cell development or recruitment in the lung

1997 • 54 citations

Elf-1 Contributes to the Function of the Complex Interleukin (IL)-2–responsive Enhancer in the Mouse IL-2 Receptor α Gene

1997 • 41 citations

Regulation of the IL-2 receptor alpha-gene. Interaction of a kappa B binding protein with cell-specific transcription factors.

1989 • 35 citations