Tumor necrosis factor signaling

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

2000 • 1,807 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Four deaths and a funeral: from caspases to alternative mechanisms

2001 • 1,605 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

2000 • 1,374 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes

1999 • 1,363 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

The Pathogenesis of Vasodilatory Shock

2001 • 1,089 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G₂/M

1999 • 997 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

1997 • 937 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

1998 • 887 citations

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

1999 • 887 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

1999 • 804 citations

NF-κB Signals Induce the Expression of c-FLIP

2001 • 799 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

2001 • 774 citations

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism

1999 • 772 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Cathepsin B contributes to TNF-α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

2000 • 702 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Lysosomal Protease Pathways to Apoptosis

2001 • 650 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

1998 • 641 citations

Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

2001 • 626 citations

Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

1999 • 612 citations

Limb and Skin Abnormalities in Mice Lacking IKKα

1999 • 609 citations

The autophagosomal–lysosomal compartment in programmed cell death

2001 • 599 citations

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

2001 • 583 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

2002 • 577 citations

NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

1999 • 574 citations

Resistance to endotoxic shock as a consequence of defective NF-kappa B activation in poly (ADP-ribose) polymerase-1 deficient mice

1999 • 569 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1999 • 554 citations

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

1998 • 553 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

2000 • 533 citations

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1998 • 531 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

2000 • 523 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1999 • 475 citations

Activation and Caspase-mediated Inhibition of PARP: A Molecular Switch between Fibroblast Necrosis and Apoptosis in Death Receptor Signaling

2002 • 470 citations

Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice

2000 • 469 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

1998 • 463 citations

Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

1998 • 461 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

2002 • 453 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II

2000 • 445 citations

NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti

2000 • 435 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

The atypical PKC-interacting protein p62 channels NF-kappa B activation by the IL-1-TRAF6 pathway

2000 • 422 citations

Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats

1999 • 418 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

1999 • 408 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

1995 • 407 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

2000 • 395 citations

The interaction of p62 with RIP links the atypical PKCs to NF-kappa B activation

1999 • 394 citations

Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor α blockade in patients with rheumatoid arthritis

2000 • 394 citations

TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90

2002 • 393 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB

2002 • 389 citations

The essential role of MEKK3 in TNF-induced NF-κB activation

2001 • 389 citations

Molecular Ordering of the Initial Signaling Events of CD95

2002 • 387 citations

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

1998 • 382 citations

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

2001 • 375 citations

The Rel/NF-κB family: friend and foe

2000 • 368 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

2000 • 365 citations

NAK is an IκB kinase-activating kinase

2000 • 365 citations

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1999 • 361 citations

The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties

2000 • 358 citations

Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction

1998 • 351 citations

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

2001 • 349 citations

The TNF-receptor-associated factor family

2001 • 344 citations

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

1993 • 341 citations

I. TNF-induced liver injury

1998 • 340 citations

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1999 • 338 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

2000 • 336 citations

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

1999 • 333 citations

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

2000 • 333 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

2001 • 324 citations

IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

2000 • 323 citations

Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

1998 • 317 citations

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

2001 • 305 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

The Enzymatic and DNA Binding Activity of PARP-1 Are Not Required for NF-κB Coactivator Function

2001 • 295 citations

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

2001 • 294 citations

The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7

2000 • 294 citations

Activation of NF-κB by FADD, Casper, and Caspase-8

2000 • 291 citations

A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation

1999 • 289 citations

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

1999 • 289 citations

Induction of cell death by tumour necrosis factor (TNF) receptor 2,CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF

1999 • 286 citations

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

2000 • 279 citations

Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis

2001 • 278 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

2002 • 274 citations

Tumor necrosis factor alpha -induced activation of c-jun N-terminal kinase is mediated by TRAF2

1997 • 273 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase (SAPK)/Jun NH2-terminal Kinase (JNK) and p38

1998 • 267 citations

Identification of a Protein with Homology to hsp90 That Binds the Type 1 Tumor Necrosis Factor Receptor

1995 • 265 citations

On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease

1999 • 263 citations

Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

1998 • 262 citations

Tumor Necrosis Factor

1988 • 261 citations

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

2000 • 259 citations

A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

1997 • 258 citations

JunD Protects Cells from p53-Dependent Senescence and Apoptosis

2000 • 257 citations

Tumor Necrosis Factor-α Supports the Survival of Osteoclasts through the Activation of Akt and ERK

2001 • 254 citations

Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia

2002 • 253 citations

Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis

1997 • 253 citations

Modularity in the TNF-receptor family

1998 • 250 citations

A20 zinc finger protein inhibits TNF and IL-1 signaling.

1996 • 250 citations

Caspase-8 Activation and Bid Cleavage Contribute to MCF7 Cellular Execution in a Caspase-3-dependent Manner during Staurosporine-mediated Apoptosis

2000 • 248 citations

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3

2001 • 248 citations

MEK kinase 1 gene disruption alters cell migration and c-Jun NH ₂ -terminal kinase regulation but does not cause a measurable defect in NF-κB activation

2000 • 240 citations

Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase

1998 • 228 citations

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

1997 • 224 citations

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

1993 • 221 citations

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

1995 • 214 citations

Differential Regulation and ATP Requirement for Caspase-8 and Caspase-3 Activation during CD95- and Anticancer Drug–induced Apoptosis

1998 • 213 citations

IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis

2001 • 208 citations

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis

1995 • 205 citations

Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

2000 • 202 citations

Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells.

1991 • 201 citations

Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling

1999 • 199 citations

NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun

2002 • 198 citations

Cathepsin B Knockout Mice Are Resistant to Tumor Necrosis Factor-α-Mediated Hepatocyte Apoptosis and Liver Injury

2001 • 197 citations

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

1998 • 196 citations

Reactive Oxygen Species Are Downstream Products of TRAF-mediated Signal Transduction

2001 • 196 citations

Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 and Protein Kinase Cζ in Primary Endothelial Cells

1999 • 192 citations

p38 MAPK signalling cascades: ancient roles and new functions

2000 • 190 citations

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop

1999 • 188 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

P53 Inhibits α6β4 Integrin Survival Signaling by Promoting the Caspase 3–Dependent Cleavage of Akt/PKB

1999 • 184 citations

Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site.

1997 • 183 citations

Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD)

2000 • 183 citations

Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane‐bound TNF in experimental cerebral malaria

1997 • 182 citations

Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis

1999 • 180 citations

FADD is required for multiple signaling events downstream of the receptor Fas.

1999 • 179 citations

TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton

1999 • 177 citations

Phosphatidylinositol 3-Kinase as a Mediator of TNF-Induced NF-κB Activation

2000 • 176 citations

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.

1995 • 175 citations

TNF induces internalization of the p60 receptor and shedding of the p80 receptor.

1994 • 175 citations

Lymphoid neoorganogenesis

1999 • 174 citations

Overexpression of Acid Ceramidase Protects from Tumor Necrosis Factor–Induced Cell Death

2000 • 174 citations

A Novel Human STE20-related Protein Kinase, HGK, That Specifically Activates the c-Jun N-terminal Kinase Signaling Pathway

1999 • 173 citations

Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1

2001 • 173 citations

TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase

1998 • 171 citations

TRAF1 Is a Negative Regulator of TNF Signaling

2001 • 170 citations

Hsp72 and Stress Kinase c-jun N-Terminal Kinase Regulate the Bid-Dependent Pathway in Tumor Necrosis Factor-Induced Apoptosis

2002 • 170 citations

The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-κB and c-Jun N-terminal Kinase

1999 • 169 citations

CD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily

2000 • 168 citations

MADD, a Novel Death Domain Protein That Interacts with the Type 1 Tumor Necrosis Factor Receptor and Activates Mitogen-activated Protein Kinase

1997 • 164 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes

2001 • 163 citations

Baculoviruses and apoptosis: the good, the bad, and the ugly

2001 • 158 citations

Signaling by the Germinal Center Kinase Family of Protein Kinases

1999 • 156 citations

Induction of early-immediate genes by tumor necrosis factor ? contribute to liver repair following chemical-induced hepatotoxicity

1997 • 152 citations

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

1999 • 152 citations

Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication.

1996 • 151 citations

Human pro-Tumor Necrosis Factor Is a Homotrimer

1996 • 150 citations

TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways.

1997 • 150 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

TWEAK can induce cell death via endogenous TNF and TNF receptor 1

1999 • 147 citations

Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro

1997 • 147 citations

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

1993 • 146 citations

Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase

1997 • 146 citations

TNF-α activates at least two apoptotic signaling cascades

1998 • 144 citations

TRAIL/Apo2L Activates c-Jun NH2-terminal Kinase (JNK) via Caspase-dependent and Caspase-independent Pathways

1998 • 144 citations

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

1994 • 144 citations

A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes

2000 • 141 citations

Tumor Necrosis Factor Induces Phosphorylation and Translocation of BAD through a Phosphatidylinositide-3-OH Kinase-dependent Pathway

1999 • 141 citations

Selective Involvement of Superoxide Anion, but Not Downstream Compounds Hydrogen Peroxide and Peroxynitrite, in Tumor Necrosis Factor-α-induced Apoptosis of Rat Mesangial Cells

2000 • 138 citations

Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells

2000 • 137 citations

The Sequence-specific DNA Binding of NF-κB Is Reversibly Regulated by the Automodification Reaction of Poly (ADP-ribose) Polymerase 1

2001 • 136 citations

TNFR80-Dependent Enhancement of TNFR60-Induced Cell Death Is Mediated by TNFR-Associated Factor 2 and Is Specific for TNFR60

1998 • 136 citations

Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis.

1998 • 130 citations

Activation of a pro‐apoptotic amplification loop through inhibition of NF‐κB‐dependent survival signals by caspase‐mediated inactivation of RIP

2000 • 130 citations

Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury

1994 • 129 citations

CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB.

1998 • 123 citations

Cytokine regulation of secondary lymphoid organ development

1998 • 123 citations

PTEN Blocks Tumor Necrosis Factor-induced NF-κB-dependent Transcription by Inhibiting the Transactivation Potential of the p65 Subunit

2002 • 122 citations

TNF in the Inflammatory Response

1999 • 122 citations

NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

2001 • 121 citations

Crucial Role of TNF Receptor Type 1 (p55), But Not of TNF Receptor Type 2 (p75), in Murine Toxoplasmosis

1998 • 119 citations

Rel/NF-κB Transcription Factors Protect against Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Up-regulating the TRAIL Decoy Receptor DcR1

2001 • 118 citations

TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis.

1993 • 118 citations

Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells

1993 • 116 citations

Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)

1999 • 114 citations

The PTEN Tumor Suppressor Protein Inhibits Tumor Necrosis Factor-induced Nuclear Factor κB Activity

2001 • 113 citations

Evidence for regulation of NF-κB by poly(ADP-ribose) polymerase

2000 • 113 citations

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

1998 • 112 citations

Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

2000 • 111 citations

Activation of Stress-activated Protein Kinase/c-Jun N-terminal Kinase, but Not NF-κB, by the Tumor Necrosis Factor (TNF) Receptor 1 through a TNF Receptor-associated Factor 2- and Germinal Center Kinase Related-dependent Pathway

1997 • 110 citations

Involvement of FAN in TNF-induced apoptosis

2001 • 110 citations

Integrating anti–tumor necrosis factor therapy in inflammatory bowel disease: current and future perspectives

2001 • 109 citations

Inhibitors of ADP-Ribosylation Impair Inducible Nitric Oxide Synthase Gene Transcription through Inhibition of NF Kappa B Activation

1998 • 107 citations

Blocking Caspase-3-Mediated Proteolysis of IKKβ Suppresses TNF-α-Induced Apoptosis

2001 • 107 citations

Emerging families of cytokines and receptors

1993 • 105 citations

Regulation of TRAF2 Signaling by Self-induced Degradation

2002 • 104 citations

Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis

2002 • 103 citations

Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion.

1999 • 101 citations

Tumor Necrosis Factor Induces Ceramide Oscillations and Negatively Controls Sphingolipid Synthases by Caspases in Apoptotic Kym-1 Cells

1998 • 100 citations

Cell Autonomous Apoptosis Defects in Acid Sphingomyelinase Knockout Fibroblasts

2001 • 97 citations

Anti–tumor necrosis factor therapies

2001 • 96 citations

Regulation of Nuclear Factor κB Transactivation

2001 • 94 citations

Resistance to the Cytotoxic Effects of Tumor Necrosis Factor α Can Be Overcome by Inhibition of a FADD/Caspase-dependent Signaling Pathway

1999 • 90 citations

Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability

2001 • 90 citations

Sensitization to Death Receptor Cytotoxicity by Inhibition of Fas-associated Death Domain Protein (FADD)/Caspase Signaling

2000 • 89 citations

Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2

2002 • 86 citations

Increased cytochromeP-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-α

2002 • 86 citations

JNK/SAPK activity contributes to TRAIL-induced apoptosis

1999 • 84 citations

Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

1998 • 84 citations

Cutting Edge: A Dominant Negative Form of TNF-α Converting Enzyme Inhibits ProTNF and TNFRII Secretion

1999 • 81 citations

Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.

1992 • 79 citations

Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice

1999 • 76 citations

Identification of Grb2 As a Novel Binding Partner of Tumor Necrosis Factor (TNF) Receptor I

1999 • 74 citations

Caspase-mediated Cleavage of Hematopoietic Progenitor Kinase 1 (HPK1) Converts an Activator of NFκB into an Inhibitor of NFκB

2001 • 73 citations

Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways

2001 • 73 citations

Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells.

1988 • 71 citations

Integrating anti–tumor necrosis factor therapy in inflammatory bowel disease: current and future perspectives

2001 • 69 citations

A model of the microtubule–kinesin complex based on electron cryomicroscopy and X-ray crystallography

1998 • 69 citations

A Novel Pathway for Tumor Necrosis Factor-α and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21 , and Phosphatidylinositol 3-Kinase

1999 • 69 citations

Caspase‐induced inactivation of the anti‐apoptotic TRAF1 during Fas ligand‐mediated apoptosis

2000 • 68 citations

Induction of inducible nitric oxide synthase is an essential part of tumor necrosis factor-alpha-induced apoptosis in MCF-7 and other epithelial tumor cells.

1999 • 67 citations

TRAF2 plays a dual role in NF‐κB‐dependent gene activation by mediating the TNF‐induced activation of p38 MAPK and IκB kinase pathways

1998 • 67 citations

Soluble and cell surface receptors for tumor necrosis factor

1992 • 66 citations

Involvement of the tumor necrosis factor receptor p75 in mediating cytotoxicity and gene regulating activities

1994 • 66 citations

Absence of the p55 Kd TNF-α receptor promotes survival in rabies virus acute encephalitis

2000 • 63 citations

A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its ‘death domain’

1995 • 61 citations

A Kinase-independent Function of Ask1 in Caspase-independent Cell Death

2001 • 60 citations

Roles of Phosphatidylinositol 3-Kinase and Rac in the Nuclear Signaling by Tumor Necrosis Factor-α in Rat-2 Fibroblasts

1999 • 59 citations

Requirement of FADD for Tumor Necrosis Factor-induced Activation of Acid Sphingomyelinase

1999 • 58 citations

Isolated limb perfusion for extremity soft-tissue sarcomas, in-transit metastases, and other unresectable tumors: Credits, debits, and future perspectives

2001 • 56 citations

cDNA Cloning and Functional Analysis of the p97 Subunit of the 26S Proteasome, a Polypeptide Identical to the Type‐1 Tumor‐Necrosis‐Factor‐Receptor‐Associated Protein‐2/55.11

1996 • 56 citations

Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF

1995 • 48 citations

TNF-Mediated Activation of the Stress-Activated Protein Kinase Pathway: TNF Receptor-Associated Factor 2 Recruits and Activates Germinal Center Kinase Related

1999 • 48 citations

Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways

2001 • 47 citations

Exacerbation of mycobacterium tuberculosis enteritis masquerading as crohn’s disease after treatment with a tumor necrosis factor-α inhibitor

2002 • 47 citations

Phosphatidylcholine-specific phospholipase C and phospholipase D are respectively implicated in mitogen-activated protein kinase and nuclear factor κB activation in tumour-necrosis-factor-α-treated immature acute-myeloid-leukaemia cells

2000 • 45 citations

NESK, a Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Is Expressed during the Late Stages of Embryogenesis

2000 • 44 citations

A20 INHIBITS NF-κB ACTIVATION DOWNSTREAM OF MULTIPLE MAP3 KINASES AND INTERACTS WITH THE IκB SIGNALOSOME

2001 • 42 citations

Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo

1999 • 42 citations

DENN, a novel human gene differentially expressed in normal and neoplastic cells

1996 • 35 citations

Tumor Necrosis Factor Receptor p55-Deficient Mice Respond to AcuteYersinia enterocoliticaInfection with Less Apoptosis and More Effective Host Resistance

2000 • 33 citations

IKKε is part of a novel PMA-inducible IkappaB kinase complex. Molecular Cell 5:513-522

2000 • 33 citations

Phenotypic analysis of TNFR1-deficient mice and characterization of TNFR1-deficient fibroblasts in vitro.

1994 • 33 citations

Activation of ERK1/2 and cPLA2 by the p55 TNF Receptor Occurs Independently of FAN

2000 • 32 citations

Role of Receptor-interacting Protein in Tumor Necrosis Factor-α-dependent MEKK1 Activation

2001 • 32 citations

Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.

1997 • 23 citations