The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Two TNF receptors

1992 • 1,048 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1993 • 573 citations

ANTIGENIC PROPERTIES OF CHEMICALLY INDUCED TUMORS*

1962 • 528 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.

1985 • 430 citations

Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity.

1985 • 287 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses.

1990 • 215 citations

Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

1993 • 211 citations

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors.

1990 • 207 citations

Assays for tumour necrosis factor and related cytokines

1989 • 204 citations

Crystallographic Evidence for Dimerization of Unliganded Tumor Necrosis Factor Receptor

1995 • 180 citations

TNF induces internalization of the p60 receptor and shedding of the p80 receptor.

1994 • 175 citations

Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram-negative sepsis.

1994 • 174 citations

Tumor necrosis factors-alpha and -beta bind to the same two types of tumor necrosis factor receptors and maximally activate the transcription factor NF-kappa B at low receptor occupancy and within minutes after receptor binding.

1990 • 132 citations

TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis.

1993 • 118 citations

Quantification and characterization of high‐affinity membrane receptors for tumor necrosis factor on human leukemic cell lines

1986 • 110 citations

Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF.

1995 • 107 citations

Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils.

1994 • 105 citations

Disparate effects of tumor necrosis factor-alpha/cachectin and tumor necrosis factor-beta/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured human endothelial cells.

1987 • 87 citations

Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines.

1989 • 78 citations

Ligand-induced Formation of p55 and p75 Tumor Necrosis Factor Receptor Heterocomplexes on Intact Cells

1997 • 77 citations

Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation.

1992 • 67 citations

Involvement of the tumor necrosis factor receptor p75 in mediating cytotoxicity and gene regulating activities

1994 • 66 citations

Binding and Crosslinking of 125I-Labeled Recombinant Human Tumor Necrosis Factor to Cell Surface Receptors1

1986 • 60 citations

Mechanism of binding of multivalent immune complexes to Fc receptors. 2. Kinetics of binding

1981 • 52 citations

Binding, Internalization, and Intracellular Processing of Proteins Interacting with Recycling Receptors

1989 • 48 citations

Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma.

1990 • 44 citations

Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies.

1992 • 44 citations

WEHI-13VAR: a stable and sensitive variant of WEHI 164 clone 13 fibrosarcoma for tumor necrosis factor bioassay

1995 • 38 citations

Functional discrepancies between tumor necrosis factor and lymphotoxin α explained by trimer stability and distinct receptor interactions

1995 • 24 citations

Role of tumor necrosis factor receptors in the activation of nuclear factor kappa B in human histiocytic lymphoma U-937 cells.

1994 • 17 citations

The relationship of receptor occupancy to the kinetics of cell death mediated by tumor necrosis factor.

1988 • 17 citations

Coexpression of the human TNF receptors TR60 and TR80 in insect cells: analysis of receptor complex formation.

1994 • 12 citations

Development of resistance to tumour necrosis factor (TNFα) in KYM-1 cells involves both TNF receptors

1993 • 11 citations