Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.

1991 • 279 citations

Interleukin 7 induces CD4+ T cell-dependent tumor rejection.

1991 • 245 citations

Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.

1991 • 225 citations

Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma.

1992 • 205 citations

Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.

1992 • 187 citations

Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: Comparison between invasive and non‐invasive areas

1992 • 158 citations

Mac-1 antigen: quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen.

1982 • 153 citations

Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.

1992 • 140 citations

Monoclonal antibody analysis of complex biological systems. Combination of cell hybridization and immunoadsorbents in a novel cascade procedure and its application to the macrophage cell surface.

1981 • 105 citations

Genetic modification of a murine fibrosarcoma to produce interleukin 7 stimulates host cell infiltration and tumor immunity.

1992 • 105 citations

Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies

1984 • 101 citations

Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity.

1991 • 99 citations

Evidence that lymphokine-activated killer cells and natural killer cells are distinct based on an analysis of congenitally immunodeficient mice.

1985 • 93 citations

Decreased tumorigenicity of a transplantable rat sarcoma following transfer and expression of an IL‐2 cDNA

1991 • 92 citations

Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumours in nu/nu mice

1988 • 79 citations

Alterations in the amino-terminal third of mouse interleukin 2: effects on biological activity and immunoreactivity.

1986 • 61 citations

Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression.

1991 • 55 citations

Lack of tumorigenicity of interleukin 4 autocrine growing cells seems related to the anti-tumor function of interleukin 4

1990 • 54 citations

Macrophage colony‐stimulating factor gene transfer into tumor cells induces macrophage infiltration but not tumor suppression

1993 • 51 citations

Interleukin‐4‐mediated tumor suppression in nude mice involves interferon‐γ

1992 • 48 citations

Suppression of Tumor Formation In Vivo by Expression of the JE Gene in Malignant Cells

1991 • 39 citations