Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability

(ADP-ribose)n participates in DNA excision repair

1980 • 1,112 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

1999 • 713 citations

Mitotic Misregulation and Human Aging

2000 • 592 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

1999 • 386 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

1998 • 350 citations

Involvement of poly(ADP-ribose) polymerase in base excision repair

1999 • 322 citations

Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span.

1992 • 295 citations

Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers

1998 • 291 citations

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1999 • 286 citations

Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

2000 • 281 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase

1997 • 204 citations

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

1995 • 200 citations

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

1992 • 171 citations

A Human Poly(ADP-ribose) Polymerase Gene Family (ADPRTL): cDNA Cloning of Two Novel Poly(ADP-ribose) Polymerase Homologues

1999 • 145 citations

Poly(ADP-ribosylation) and apoptosis.

1999 • 139 citations

From DNA damage and stress signalling to cell death : poly-ADP-ribosylation reactions

2000 • 135 citations

Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

1998 • 135 citations

Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens

2000 • 120 citations

trans-Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N-Methyl-N′-Nitro-N-Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon

1995 • 113 citations

Chromosome Breaks and Genomic Instability

2000 • 88 citations

Characterization of sPARP-1

2000 • 79 citations

Selective Loss of Poly(ADP-ribose) and the 85-kDa Fragment of Poly(ADP-ribose) Polymerase in Nucleoli during Alkylation-induced Apoptosis of HeLa Cells

1999 • 75 citations

Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity

2000 • 65 citations

pADPRT‐2: a novel mammalian polymerizing(ADP‐ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans¹

1999 • 53 citations

Overexpression of Human poly(ADP‐Ribose) Polymerase in Transfected Hamster Cells Leads to Increased Poly(ADP‐Ribosyl)ation and Cellular Sensitization to γ irradiation

1997 • 52 citations

Genomic Instability and Its Role in Neoplasia

1997 • 50 citations

γ-Radiation induced ADP-ribosyl transferase activity and mammalian longevity

1985 • 38 citations

Poly(ADP‐Ribosyl)ation, Genomic Instability, and Longevity

2000 • 23 citations

Alkylating Agent Hypersensitivity in Poly(Adenosine Diphosphate-Ribose) Polymerase Deficient Cell Lines

1991 • 20 citations

Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells

1997 • 16 citations