The p70 tumor necrosis factor receptor mediates cytotoxicity

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.

1986 • 674 citations

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

1992 • 654 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

1991 • 576 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia

1985 • 525 citations

A Chemoattractant Receptor Controls Development in Dictyostelium discoideum

1988 • 465 citations

Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

1990 • 369 citations

Two Different Cell Types have Different Major Receptors for Human Tumor Necrosis Factor (TNFα)

1989 • 368 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

1986 • 312 citations

Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity.

1985 • 287 citations

Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha.

1991 • 230 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors.

1990 • 207 citations

Analysis of gene expression during differentiation of adipogenic cells in culture and hormonal control of the developmental program.

1984 • 203 citations

Identity of differentiation inducing factor and tumour necrosis factor

1986 • 181 citations

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor

1991 • 173 citations

Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors.

1990 • 173 citations

Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum.

1981 • 160 citations

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.

1991 • 160 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation.

1990 • 144 citations

Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor.

1990 • 139 citations

Tumor Necrosis Factor Inhibits Human Myogenesis In Vitro

1988 • 122 citations

Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo.

1988 • 97 citations

Effects of growth factors on the antiproliferative activity of tumor necrosis factors.

1987 • 96 citations

Human Mn superoxide dismutase cDNA sequence

1987 • 91 citations

Evidence for two mechanisms by which tumor necrosis factor kills cells

1989 • 80 citations

Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.

1991 • 76 citations

Tumor necrosis factor inhibits human myogenesis in vitro.

1988 • 66 citations

Binding and Crosslinking of 125I-Labeled Recombinant Human Tumor Necrosis Factor to Cell Surface Receptors1

1986 • 60 citations

Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by a defect in arachidonic acid biosynthesis.

1991 • 57 citations

Resistance of tumor cells to tumor necrosis factor

1988 • 45 citations

Amplified expression of tumor necrosis factor receptor in cells transfected with Epstein-Barr virus shuttle vector cDNA libraries.

1990 • 30 citations

Tumor necrosis factor receptor genes,TNFR1 andTNFR2, on human chromosomes 12 and 1

1991 • 16 citations