Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses

1996 • 728 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

1998 • 533 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 485 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

MEKK1 activates both IκB kinase α and IκB kinase β

1998 • 382 citations

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.

1993 • 361 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

1999 • 333 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

1991 • 269 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.

1992 • 252 citations

Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase

1998 • 228 citations

IKKγ Serves as a Docking Subunit of the IκB Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein

1999 • 227 citations

Human T-Cell Leukemia Virus Type 1 Tax Induction of NF-κB Involves Activation of the IκB Kinase α (IKKα) and IKKβ Cellular Kinases

1998 • 221 citations

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

1999 • 216 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

1998 • 198 citations

Human T-Cell Leukemia Virus Type I Tax Activation of NF-ΝB/Rel Involves Phosphorylation and Degradation of IΙBκ and RelA (p65)-Mediated Induction of the italic toc-rel Gene

1994 • 186 citations

IKKγ Mediates the Interaction of Cellular IκB Kinases with the Tax Transforming Protein of Human T Cell Leukemia Virus Type 1

1999 • 181 citations

Persistent activation of NF-κB by the Tax transforming protein of HTLV-1: hijacking cellular IκB kinases

1999 • 181 citations

Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis

1999 • 180 citations

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1988 • 171 citations

Inactivation of IκBβ by the Tax Protein of Human T-Cell Leukemia Virus Type 1: a Potential Mechanism for Constitutive Induction of NF-κB

1996 • 166 citations

NF-κB-inducing Kinase and IκB Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-κB Activation

1998 • 155 citations

Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.

1991 • 153 citations

Both Amino- and Carboxyl-Terminal Sequences within IκBα Regulate Its Inducible Degradation

1996 • 153 citations

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.

1994 • 142 citations

CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

1994 • 132 citations

Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation

1991 • 116 citations

Activation of NF-κB by Phosphatase Inhibitors Involves the Phosphorylation of IκBα at Phosphatase 2A-sensitive Sites

1995 • 96 citations

Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.

1994 • 89 citations

Characterization of a Mutant Cell Line That Does Not Activate NF-κB in Response to Multiple Stimuli

1997 • 82 citations

Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta

1996 • 74 citations

CD28 Mediates a Potent Costimulatory Signal for Rapid Degradation of IκBβ Which Is Associated with Accelerated Activation of Various NF-κB/Rel Heterodimers

1996 • 70 citations

IκB Kinases Serve as a Target of CD28 Signaling

1998 • 69 citations

cis-Acting transcriptional regulatory sequences in the gibbon ape leukemia virus (GALV) long terminal repeat

1987 • 61 citations

Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells

1995 • 60 citations

The NF- B Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 47 citations

Cellular transformation by human T-cell leukemia virus type I

1996 • 36 citations

Effect of CD28 Signal Transduction on c-Rel in Human Peripheral Blood T Cells

1994 • 21 citations