Programmed Cell Death in Development

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Excitotoxic cell death

1992 • 2,307 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Nerve growth factor.

1968 • 2,025 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Expression of baculovirus P35 prevents cell death in Drosophila

1994 • 1,037 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Death in Embryonic Systems

1966 • 943 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

1993 • 855 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Local control of neurite development by nerve growth factor

1977 • 732 citations

Programmed cell death during Drosophila embryogenesis

1993 • 710 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Müllerian-inhibiting substance function during mammalian sexual development

1994 • 661 citations

Cell death in the development of the lateral motor column of the chick embryo

1975 • 658 citations

Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein

1960 • 651 citations

Lens Differentiation in Vertebrates

1981 • 638 citations

Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo

1991 • 635 citations

Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

1994 • 630 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

The Caenorhabditis elegans male: Postembryonic development of nongonadal structures

1980 • 588 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye

1993 • 557 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

1994 • 550 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

The human blastocyst: cell number, death and allocation during late preimplantation development in vitro

1989 • 548 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Cell death during differentiation of the retina in the mouse

1984 • 531 citations

A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome

1992 • 523 citations

Apoptosis: a different type of cell death

1992 • 523 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Patterns of cell death.

1988 • 470 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.

1991 • 463 citations

Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death

1992 • 458 citations

Definition and incidence of apoptosis : an historical perspective

1991 • 458 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Programmed cell death—I. Cytology of degeneration in the intersegmental muscles of the Pernyi silkmoth

1965 • 449 citations

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

1990 • 447 citations

Palate development

1988 • 440 citations

The emergence of order in the Drosophila pupal retina

1989 • 439 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

1993 • 433 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Apoptosis: The Molecular Basis of Cell Death

1991 • 425 citations

Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor

1981 • 407 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

The neurotrophic theory and naturally occurring motoneuron death

1989 • 397 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

1994 • 396 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Mutations Affecting Programmed Cell Deaths in the Nematode Caenorhabditis elegans s

1983 • 389 citations

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1992 • 387 citations

Programmed cell death—II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths

1964 • 384 citations

Programmed cell death in Caenorhabditis elegans

1994 • 379 citations

Cell death in normal and rough eye mutants of Drosophila

1991 • 364 citations

Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ culture

1966 • 364 citations

Dicing with death: dissecting the components of the apoptosis machinery

1994 • 363 citations

Myogenic cell lineages

1992 • 360 citations

Cascade Induction of c-fos, c-myc, and Heat Shock 70K Transcripts during Regression of the Rat Ventral Prostate Gland

1988 • 355 citations

Macrophages are required for cell death and tissue remodeling in the developing mouse eye

1993 • 355 citations

Extracellular ATP as a trigger for apoptosis or programmed cell death.

1991 • 342 citations

Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons

1993 • 338 citations

Perspectives on mammalian cell death

1988 • 334 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.

1993 • 320 citations

Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development

1978 • 318 citations

Post-embryonic development in the ventral cord of Caenorhabditis elegans

1976 • 314 citations

Apoptosis in metanephric development.

1992 • 310 citations

Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis)

1993 • 307 citations

Naturally Occurring Neuron Death and Its Regulation by Developing Neural Pathways

1982 • 306 citations

Cell death of motoneurons in the chick embryo spinal cord. IV. Evidence that a functional neuromuscular interaction is involved in the regulation of naturally occurring cell death and the stabilization of synapses

1979 • 299 citations

Cellular death in morphogenesis of the avian wing

1962 • 298 citations

Synaptic transmission and cell death during normal ganglionic development

1974 • 297 citations

Metamorphosis of the central nervous system of Drosophila

1990 • 293 citations

Cell death in biology and pathology

1981 • 290 citations

A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant

1987 • 280 citations

Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease

1993 • 279 citations

Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse

1989 • 277 citations

Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

1993 • 276 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

Members of several gene families influence survival of rat motoneurons in vitro and in vivo

1993 • 274 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

Active cell death in hormone-dependent tissues

1992 • 264 citations

Even-numbered rhombomeres control the apoptotic elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain

1993 • 260 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

Apoptosis induced by inhibition of intercellular contact.

1994 • 256 citations

Topographic targeting errors in the retinocollicular projection and their elimination by selective ganglion cell death

1986 • 254 citations

Neuromuscular blockade increases motoneurone survival during normal cell death in the chick embryo

1978 • 246 citations

Hormone-induced cell death. Purification ad properties of thymocytes undergoing apoptosis after glucocorticoid treatment.

1982 • 244 citations

Gene expression during metamorphosis: An ideal model for post‐embryonic development

1993 • 243 citations

The Bcl-2 family of proteins: regulators of cell death and survival

1994 • 238 citations

Regulation of neurotrophin receptors during the maturation of the mammalian visual system

1994 • 233 citations

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

1993 • 231 citations

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

1989 • 230 citations

Detection of the initial stages of DNA fragmentation in apoptosis.

1993 • 228 citations

Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer

1986 • 224 citations

Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells.

1993 • 223 citations

Delayed internucleosomal DNA fragmentation in programmed cell death

1993 • 222 citations

Rapidin VivoEffects of Glucocorticoids on the Integrity of Rat Lymphocyte Genomic Deoxyribonucleic Acid*

1986 • 218 citations

The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation

1992 • 216 citations

Coincident loss of mitochondria and nuclei during lens fiber cell differentiation

1992 • 215 citations

Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform

1993 • 214 citations

Activation of polyubiquitin gene expression during developmentally programmed cell death

1990 • 214 citations

Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor

1988 • 213 citations

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.

1994 • 210 citations

Cell death and removal in the cerebral cortex during development

1992 • 208 citations

Developmental and regional expression of thyroid hormone receptor genes during Xenopus metamorphosis

1991 • 205 citations

Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans.

1994 • 204 citations

Evidence That the Mechanism of Prenatal Germ Cell Death in the Mouse Is Apoptosis

1993 • 203 citations

The role of cytosolic Ca2+ in cell injury, necrosis and apoptosis

1992 • 199 citations

Interaction between inner cell mass and trophectoderm of the mouse blastocyst:I. A study of cellular proliferation

1978 • 196 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

Apoptosis as the Mode of Uterine Epithelial Cell Death during Embryo Implantation in Mice and Rats1

1987 • 195 citations

Genesis and death of vocal control neurons during sexual differentiation in the zebra finch

1989 • 193 citations

Postmetamorphic cell death in the nervous and muscular systems of Drosophila melanogaster

1990 • 193 citations

The pathology of development : a study of inherited skeletal disorders in animals

1963 • 192 citations

DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.

1990 • 185 citations

On the origin and development of the ventrolateral abdominal muscles in the avian embryo

1983 • 184 citations

Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.

1994 • 184 citations

Perspectives on mammalian cell death.

1987 • 183 citations

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells.

1994 • 182 citations

The epithelial-mesenchymal interface of the male rat Mullerian duct: Loss of basement membrane integrity and ductal regression

1982 • 179 citations

Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression

1987 • 179 citations

Cell death in the morphogenesis and teratogenesis of the heart

1975 • 178 citations

Cell death in the mammalian visual system during normal development: I. Retinal ganglion cells

1982 • 175 citations

The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein.

1993 • 174 citations

Two C. elegans genes control the programmed deaths of specific cells in the pharynx

1991 • 171 citations

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product.

1987 • 167 citations

The fate of medial edge epithelial cells during palatal fusion in vitro: an analysis by Dil labelling and confocal microscopy

1992 • 165 citations

Bcl-2 protein expression during murine development.

1994 • 164 citations

Changes in the numbers of optic nerve fibers during late prenatal and postnatal development in the albino rat

1985 • 162 citations

Programmed cell death. Activation of lysis by a mechanism involving the synthesis of protein

1969 • 162 citations

Epithelial-mesenchymal transformation during palatal fusion: carboxyfluorescein traces cells at light and electron microscopic levels

1992 • 162 citations

Control of lens epithelial cell survival.

1993 • 161 citations

Gene activation is required for developmentally programmed cell death.

1990 • 160 citations

The vertebrate tail bud: three germ layers from one tissue

1992 • 160 citations

Programmed death of nonproliferating androgen-independent prostatic cancer cells.

1991 • 159 citations

Development in mammals

1977 • 158 citations

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

1991 • 157 citations

Neurites Can Remain Viable after Destruction of the Neuronal Soma by Programmed Cell Death (Apoptosis)

1994 • 154 citations

Steroid regulation of neuronal death in the moth nervous system

1984 • 153 citations

Epithelial cell death and cyclic AMP increase during palatal development.

1975 • 152 citations

Le^y antigen expression is correlated with apoptosis (programmed cell death)

1993 • 148 citations

Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.

1986 • 147 citations

Cell death of motoneurons in the chick embryo spinal cord. VI. Reduction of naturally occurring cell death in the thoracolumbar column of terni by nerve growth factor

1982 • 147 citations

A transgene insertional mutation at an imprinted locus in the mouse genome

1990 • 147 citations

S100 is present in developing chicken neurons and schwann cell and promotes motor neuron survival in vivo

1992 • 145 citations

DNA degradation in terminally differentiating lens fiber cells from chick embryos.

1977 • 141 citations

Programmed cell death is affected in the novel mouse mutant Fused toes (Ft)

1994 • 141 citations

c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha.

1994 • 141 citations

Muscle development in the grasshopper embryo

1985 • 140 citations

Cell death in embryogenesis

1981 • 138 citations

The cell cycle and cell death

1993 • 137 citations

PROGRAMMED CELL DEATH: CONCEPT, MECHANISM AND CONTROL

1992 • 136 citations

ULTRASTRUCTURAL CHANGES IN REGRESSING TAIL MUSCLES OF XENOPUS LARVAE AT METAMORPHOSIS

1964 • 134 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

Retinoic‐acid‐induced limb malformations resulting from apical ectodermal ridge cell death

1988 • 131 citations

Ellipse mutations in the Drosophila homologue of the EGF receptor affect pattern formation, cell division, and cell death in eye imaginal discs

1992 • 131 citations

Cell death in biology and pathology

1982 • 131 citations

Calcium channel antagonists delay regression of androgen‐dependent tissues and suppress gene activity associated with cell death

1988 • 128 citations

Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival

1991 • 127 citations

Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development

1988 • 126 citations

Programmed cell death during the earliest stages of spinal cord development in the chick embryo: A possible means of early phenotypic selection

1994 • 126 citations

Prolactin inhibits both thyroid hormone-induced morphogenesis and cell death in cultured amphibian larval tissues

1991 • 125 citations

Closure of the neural tube in the cephalic region of the mouse embryo

1977 • 125 citations

Cytochemical identification of programmed cell death in the fusing fetal mouse palate by specific labelling of DNA fragmentation

1994 • 124 citations

Programmed cell death in the nervous system of an adult insect

1983 • 123 citations

Antibody against single-stranded DNA detects both programmed cell death and drug-induced apoptosis

1994 • 122 citations

Retinoic acid-induced spina bifida: evidence for a pathogenetic mechanism

1990 • 120 citations

Apoptosis and signal transduction: clues to a molecular mechanism

1993 • 119 citations

Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily.

1993 • 119 citations

[Lysosomes of the intestinal epithelium. An embryological investigation].

1975 • 118 citations

Isolation and characterization of the chickenbcl–2gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo

1992 • 118 citations

Naturally occurring cell death in the developing dentate gyrus of the rat

1991 • 116 citations

Programmed cell death and apoptosis

1991 • 115 citations

Requirement of a neural tube signal for the differentiation of neural crest cells into dorsal root ganglia

1986 • 115 citations

Multiple pathways to apoptosis.

1993 • 113 citations

Internucleosomal dna fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud

1993 • 113 citations

Rapid onset of neuronal death induced by blockade of either axoplasmic transport or action potentials in afferent fibers during brain development

1992 • 112 citations

A comparative study of the differentiation and involution of the mullerian duct and wolffian duct in the male and female fetal mouse

1979 • 112 citations

Cytolysis mediated by ionophores and pore‐forming agents: role of intracellular calcium in apoptosis

1994 • 112 citations

Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency

1991 • 111 citations

Apoptosis or programmed cell death?

1993 • 110 citations

The Relation of Programmed Cell Death to Development and Reproduction: Comparative Studies an an Attempt at Classification.

1982 • 108 citations

Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development

1991 • 108 citations

Sensory ganglia require neurotrophin-3 early in development

1994 • 107 citations

Cell death and the development of limb form and skeletal pattern in normal andwingless(ws) chick embryos

1973 • 106 citations

Trophoblast‐decidual cell interactions and establishment of maternal blood circulation in the parietal yolk sac placenta of the rat

1987 • 106 citations

Apoptotic Cell Death in the Mouse Limb and Its Suppression in the Hammertoe Mutant

1994 • 105 citations

Cell Death in Invertebrate Nervous Systems

1984 • 104 citations

Ciliary neurotrophic factor maintains motoneurons and their target muscles in developing rats

1993 • 104 citations

Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal

1982 • 102 citations

Cell redundancy in the zona-intact preimplantation mouse blastocyst: a light and electron microscope study of dead cells and their fate.

1974 • 102 citations

The ins and outs of programmed cell death duringC. elegansdevelopment

1994 • 100 citations

In vitro analysis of the control of cell death in a zone of prospective necrosis from the chick wing bud

1968 • 100 citations

Electrical stimulation of hindlimb increases neuronal cell death in chick embryo

1982 • 100 citations

Inhibition of palatal epithelial cell death by altered protein synthesis

1976 • 100 citations

Lack of correspondence between mRNA expression for a putative cell death molecule (SGP‐2) and neuronal cell death in the central nervous system

1991 • 99 citations

Mechanism of programmed cell death in the blastocyst.

1989 • 98 citations

Cell death in chick embryos as studied by electron microscopy.

1961 • 97 citations

Terminal lens cell differentiation I. Histological and microspectrophotometric analysis of nuclear Degeneration

1970 • 97 citations

Myocardial cell death in the embryonic chick ventricle

1969 • 97 citations

The development of rat palatal shelves in vitro

1975 • 94 citations

Major role for neuronal death during brain development: refinement of topographical connections.

1987 • 91 citations

A reevaluation of the role of innervation in primary and secondary myogenesis in developing chick muscle

1991 • 90 citations

Programmed cell death : the cellular and molecular biology of apoptosis

1993 • 90 citations

DNA strand breaks in rat tissues as detected by in situ nick translation

1986 • 89 citations

Immunocytochemical detection of anti-müllerian hormone in Sertoli cells of various mammalian species including human.

1987 • 87 citations

The role of cell death genes during development

1991 • 86 citations

Ultrastructural observations on cell necrosis during formation of the neural tube in mouse embryos

1973 • 86 citations

History of the discovery of neuronal death in embryos

1992 • 85 citations

Molecular and morphologic changes during the epithelial-mesenchymal transformation of palatal shelf medial edge epithelium in vitro.

1991 • 84 citations

The Lysosomal System in Neuronal Cell Death: A Review^a

1993 • 83 citations

Programmed cell death in the Müllerian duct induced by Müllerian inhibiting substance

1977 • 82 citations

Programmed neuronal death in insect development

1992 • 82 citations

Limb development in the polydactylous talpid3 mutant of the fowl

1967 • 82 citations

Role of cell death in the topogenesis of neuronal distributions in the developing cat retinal ganglion cell layer

1987 • 81 citations

Apoptosis: a general comment

1991 • 81 citations

Developmental and abnormal cell death in C. Elegans

1992 • 80 citations

Insect muscle as a model for programmed cell death

1992 • 78 citations

Molecular genetics of cell death in the nematode Caenorhabditis elegans

1992 • 77 citations

Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos

1989 • 76 citations

Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation.

1992 • 75 citations

Cell death in the ‘opaque patch’ in the central mesenchyme of the developing chick limb: a cytological, cytochemical and electron microscopic analysis

1971 • 74 citations

Glucocorticoid-induced proteins in rat thymus cells.

1981 • 74 citations

Cell death in metamorphosis

1981 • 74 citations

Evidence of a role for cell death in the disappearance of the embryonic human tail

1978 • 73 citations

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis

1992 • 73 citations

Cell death in developing systems.

1988 • 71 citations

Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition.

1994 • 70 citations

Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.

1992 • 68 citations

Differential mitosis and degeneration patterns in relation to the alterations in the shape of the embryonic ectoderm of early post-implantation mouse embryos

1980 • 68 citations

Genetic inhibition of mesenchymal cell death and the development of form and skeletal pattern in the limbs oftalpid3(ta3) mutant chick embryos

1974 • 68 citations

Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death

1994 • 68 citations

Role of Calcium in Toxic and Programmed Cell Death

1991 • 67 citations

Reduction of intramuscular nerve branching and synaptogenesis is correlated with decreased motoneuron survival

1993 • 67 citations

Interdigital cell death during limb development of the turtle and lizard with an interpretation of evolutionary significance

1977 • 67 citations

The development of human skeletal muscle with particular reference to muscle cell death

1972 • 65 citations

Retrograde transport of nerve growth factor in chicken embryo.

1979 • 65 citations

Expression of Tumor Necrosis Factor Alpha in the Developing Nervous System

1991 • 64 citations

The molecular mechanisms of neuronal apoptosis

1994 • 64 citations

Retinoic acid alters EGF receptor expression during palatogenesis

1988 • 64 citations

Cell death in cranial neural crest development

1992 • 64 citations

Chapter 7. Epithelial-Mesenchymal Interactions During Vertebrate Palatogenesis

1984 • 64 citations

Effects of chronic injections of α-bungarotoxin on embryonic cell death

1979 • 63 citations

Morphogenetic processes involved in the remodeling of the tail region of the chick embryo

1981 • 63 citations

Epithelial autolysis during implantation of the mouse blastocyst: an ultrastructural study

1975 • 63 citations

Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition

1994 • 62 citations

Techniques for demonstrating cell death

1981 • 62 citations

Cell death in the anuran tadpole tail: Thyroid hormone induces keratinization and tail-specific growth inhibition of epidermal cells

1989 • 62 citations

Effect of epidermal growth factor on secondary palatal epithelium in vitro: tissue isolation and recombination studies

1980 • 61 citations

Differentiation of cultured palatal shelves from alligator, chick, and mouse embryos

1984 • 61 citations

Naturally occurring cell death in the subicular complex and hippocampus in the rat during development

1990 • 59 citations

Comparisons of the effects of TCDD and hydrocortisone on growth factor expression provide insight into their interaction in the embryonic mouse palate

1992 • 59 citations

Activation patterns of embryonic chick hind‐limb muscles following blockade of activity and motoneurone cell death.

1986 • 59 citations

Mitosis and cell death in the tail of the chick embryo

1989 • 57 citations

Programmed cell death: Dying cells synthesize a co‐ordinated, unique set of proteins in two different episodes of cell death

1988 • 57 citations

Calcium chelators induce apoptosis — evidence that raised intracellular ionised calcium is not essential for apoptosis

1994 • 56 citations

Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro

1994 • 56 citations

Potential roles for tumour necrosis factor? during embryonic development

1995 • 55 citations

Calcium wave fronts that cross gap junctions may signal neuronal death during development

1994 • 55 citations

Cell death during development of a forebrain nucleus involved with vocal learning in zebra finches

1989 • 55 citations

Constitutive expression of tnf-α and -β genes in mouse embryo: roles of cytokines as regulator and effector on development

1994 • 54 citations

Cellular and molecular aspects of mouse primordial germ cell migration and proliferation in culture.

1992 • 53 citations

Up‐regulation of aFGF expression in quiescent cells is related to cell survival

1994 • 52 citations

A segmented pattern of cell death during development of the chick embryo

1992 • 52 citations

Talpid² mutant chick limb has anteroposterior polarity and altered patterns of programmed cell death

1991 • 51 citations

Effect of epidermal growth factor/urogastrone on glycosaminoglycan synthesis and accumulation in vitro in the developing mouse palate

1985 • 50 citations

The relationship of intramuscular nerve branching and synaptogenesis to motoneuron survival

1992 • 50 citations

Chapter 10. Biochemical Mechanism of Glucocorticoid-and Phenytoin-Induced Cleft Palate

1984 • 49 citations

Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1.

1992 • 49 citations

Interplay between thyroid hormone and estrogen in modulating expression of their receptor and vitellogenin genes during Xenopus metamorphosis

1994 • 49 citations

Evidence that at least some of the motor nerve cells that die during development have first made peripheral connections

1976 • 49 citations

Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes.

1988 • 48 citations

The absence of cell death during development of free digits in amphibians

1977 • 48 citations

Inhibition of Programmed Cell Death in Mouse Embryonic Palate in Vitro by Cortisol and Phenytoin: Receptor Involvement and Requirement of Protein Synthesis

1983 • 48 citations

Cell death in the posterior necrotic zone (PNZ) of the chick wing-bud: a stereoscan and ultrastructural survey of autolysis and cell fragmentation

1978 • 46 citations

Evidence linking programmed cell death in the blastocyst to polyamine oxidation

1990 • 45 citations

Distribution of TNF alpha-like proteins correlates with some regions of programmed cell death in the chick embryo.

1994 • 45 citations

Antibodies against mouse nerve growth factor interfere in vivo with the development of avian sensory and sympathetic neurones

1988 • 44 citations

Leukemia Inhibitory Factor and Neurotrophins Support Overlapping Populations of Rat Nodose Sensory Neurons in Culture

1994 • 43 citations

An experimental and morphological analysis of the tail bud mesenchyme of the chick embryo

1986 • 43 citations

Differential expression of two MSH-related homeobox genes Chox-7 and Chox-8 during chick limb development

1992 • 42 citations

Calcium‐Induced Neuronal Degeneration: A Normal Growth Cone Regulating Signal Gone Awry (?)

1989 • 42 citations

Chapter 2. Role of Extracellular Matrices in Palatal Shelf Closure

1984 • 41 citations

The Neural Crest: a Study On Cell Degeneration and the Improbability of Cell Migration in Mouse Embryos

1979 • 41 citations

Fragmentation of DNA in the retina of chicken embryos coincides with retinal ganglion cell death

1992 • 39 citations

Interleukin-2 Induces Apoptosis in Mouse Thymocytes

1993 • 39 citations

Cell death during the formation of tubular heart of the chick embryo

1975 • 39 citations

[The regression of the mesonephros in the chick embryo. A study of acid phosphatase and catepsin activity. Biochemical, histochemical, and electron microscopic observations].

1966 • 38 citations

Neuronal death, a tradition of dying

1992 • 38 citations

Commitment to Cell Death Is Signaled by the Appearance of a Terminin Protein of 30 kDa

1994 • 37 citations

The expression pattern of the chicken homeobox-containing gene GHox-7 in developing polydactylous limb buds suggests its involvement in apical ectodermal ridge-directed outgrowth of limb mesoderm and in programmed cell death

1993 • 36 citations

Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily

1993 • 36 citations

Nerve growth factor and neuronal cell death

1990 • 36 citations

The early development of the avian embryo. II. Mesoderm formation and the distribution of presumptive embryonic material

1938 • 35 citations

Cell death in the optic tectum of the developing rat

1977 • 35 citations

Cell redundancy in the zona-intact preimplantation mouse blastocyst: a light and electron microscope study of dead cells and their fate

1974 • 34 citations

Expression of tumor necrosis factor‐α (TNFα)‐cross‐reactive proteins during early chick embryo development

1993 • 34 citations

Reduction of the rate of outgrowth, cell density, and cell division following removal of the apical ectodermal ridge of the chick limb-bud

1977 • 33 citations

Bcl-2 expressed using a retroviral vector is localized primarily in the nuclear membrane and the endoplasmic reticulum of chicken embryo fibroblasts.

1994 • 33 citations

Inhibitory effects of actinomycin D and cycloheximide on neuronal death in adult Manduca sexta

1994 • 33 citations

Tumor necrosis factor‐α and embryonic mouse lung morphogenesis

1994 • 32 citations

The developmentally-regulatedDrosophilagenerox8encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins

1993 • 31 citations

Effects of a protein synthesis inhibitor on the hormonally mediated regression and death of motoneurons in the tobacco hornworm, Manduca sexta

1993 • 30 citations

Mechanisms for Programmed Cell Death in the Nervous System of a Moth

2007 • 29 citations

Differentiation of the inner cell mass of the baboon blastocyst

1990 • 29 citations

Chapter 6. Morphological, Cellular, and Biochemical Aspects of Differentiation of Normal Hamster and Teratogen-Treated Palate in and Chick Embryos

1984 • 29 citations

Scanning and light microscope studies of the development of the chick embryo semilunar heart valves

1979 • 29 citations

Programmed death of peripheral pioneer neurons in the grasshopper embryo

1987 • 29 citations

Histochemical detection of DNA strand scissions in mammalian cells by nick translation

1985 • 28 citations

Programmed cell death in Drosophila

1994 • 28 citations

Synthesis of Specific Proteins in Trophic Factor‐Deprived Neurons Undergoing Apoptosis

1994 • 28 citations

Anti-apogens and anti-engulfens: monoclonal antibodies reveal specific antigens on apoptotic and engulfment cells during chicken embryonic development

1994 • 28 citations

Glucocorticoid-Induced Messenger Ribonucleic Acids in Rat Thymic Lymphocytes: Rapid Primary Effects Specific for Glucocorticoids

1986 • 27 citations

Cell death in suboptic necrotic centers of chick embryo diencephalon and their topographic relationship with the earliest optic fiber fascicles

1988 • 27 citations

DNAase activities in embryonic chicken lens: in epithelial cells or in differentiating fibers where chromatin is progressively cleaved

1991 • 27 citations

The involvement of protein kinase C in activation-induced cell death in T-cell hybridoma

1992 • 26 citations

Talpid² limb bud mesoderm does not express GHox‐8 and has an altered expression pattern of GHox‐7

1992 • 26 citations

Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules.

1993 • 26 citations

A tissue culture system for studying lens cell differentiation

1981 • 26 citations

Differential staining of dead and dying embryonic cells with a simple new technique

1986 • 26 citations

Cell movement, proliferation and death in the formation of the embryonic axis of the rabbit

1966 • 26 citations

Inhibition of epithelial cell death in the secondary palate in vitro by alteration of lysosome function.

1978 • 25 citations

Differentiation of the avian secondary palate

1983 • 25 citations

The early development of the sheep trophoblast and the involvement of cell death

1985 • 25 citations

Localization of immunoreactive ubiquitin in the nervous system of the Manduca sexta moth

1994 • 25 citations

DNA Fragmentation during the Programmed Cell Death in the Chick Limb Buds

1994 • 24 citations

The lens: A model for chromatin degradation studies in terminally differentiating cells

1989 • 22 citations

Fibroblast growth factor and culture in monolayer rescue mesoderm cells destined to die in the developing avian wing

1991 • 22 citations

Muscular dystrophy and muscle cell death in normal foetal development

1974 • 22 citations

Chapter 3 Hormones and programmed cell death: insights from invertebrate studies

1990 • 22 citations

Morphogenetic movements during the early development of the chick eye. An ultrastructural and spatial reconstructive study. B. Invagination of the optic vesicle and fusion of its walls.

1980 • 21 citations

Somatostatin (SRIF) Prevents Natural Motoneuron Cell Death in Embryonic Chick Spinal Cord

1991 • 21 citations

Expression of the epidermal growth factor receptor in developing fetal mouse palates: An immunohistochemical study

1990 • 20 citations

Autonomous death of amphibian (Xenopus laevis) cranial myotomes

1989 • 20 citations

Expression of Bcl-2 protein in murine neural cells in culture

1994 • 19 citations

Retinoic acid alters epithelial differentiation during palatogenesis.

1991 • 19 citations

Cell death in the dorsal part of the chick optic cup. Evidence for a new necrotic area

1984 • 19 citations

Pronephric regression during larval life in the sea lamprey, Petromyzon marinus L.

1990 • 19 citations

Absence of endonuclease activation during acute cell death in renal proximal tubules

1993 • 18 citations

Müllerian inhibiting substance: New perspectives and future directions

1993 • 15 citations

Cell death during the postnatal morphogenesis of the normal rabbit kidney and in experimental renal polycystosis.

1978 • 15 citations

8 Control of Cell Lineage and Cell Fate during Nematode Development

1991 • 14 citations

An ultrastructural and histochemical study of the development of secondary palate in Japanese quail, Coturnix coturnix japonica.

1985 • 14 citations

Cell death during normal gastrulation in the newt, Cynops pyrrhogaster

1986 • 14 citations

The role of target size in neuronal survival

1992 • 14 citations

The development of the trigeminal (V) motor nucleus in normal and tubocurare treated chick embryos

1986 • 11 citations

Cell death, thyroxinf and the development of Rana temporaria larvae with special reference to the pronephros

1971 • 10 citations

Vital staining for cell death in chick limb buds: a histochemical technique in the analysis of control of limb development.

1986 • 9 citations

Formation of the chick mesonephros. 1. General outline of development.

1975 • 9 citations

Mutants with Delayed Cell Death of the Ptilinal Head Muscles inDrosophila

1992 • 7 citations

Involution of the Wolffian duct in the rat.

1993 • 6 citations

A cell division counter exists in the chick embryo myogenic lineage.

1992 • 1 citations