Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

An improved colorimetric assay for interleukin 2

1986 • 858 citations

[1] Assays of protein kinase

1983 • 832 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Death and the cell

1986 • 616 citations

Mouse myelomas and lymphomas in culture

1970 • 559 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*

1987 • 363 citations

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

1987 • 293 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

Cloning of mouse myeloma cells and detection of rare variants

1972 • 243 citations

Identification of mRNAs associated with programmed cell death in immature thymocytes.

1991 • 242 citations

Characterization of a glucocorticoid-sensitive human lymphoid cell line.

1977 • 217 citations

Dexamethasone induces irreversible G₁ arrest and death of a human lymphoid cell line

1979 • 201 citations

Differentiated functions expressed by cultured mouse lymphoma cells. II. Theta antigen, surface immunoglobulin and a receptor for antibody on cells of a thymoma cell line.

1973 • 184 citations

The chemotherapy of lymphomas: looking back, moving forward--the Richard and Hinda Rosenthal Foundation award lecture.

1987 • 180 citations

Induction of Cytolysis of Cultured Lymphoma Cells by Adenosine 3′:5′-Cyclic Monophosphate and the Isolation of Resistant Variants

1973 • 176 citations

Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.

1985 • 172 citations

Diploid and haploid states of the glucocorticoid receptor gene of mouse lymphoid cell lines

1977 • 170 citations

Cyclic AMP-Dependent Protein Kinase: Pivotal Role in Regulation of Enzyme Induction and Growth

1975 • 164 citations

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

1991 • 157 citations

Functional Characterizations of the Androgen Receptor Confirm that the Molecular Basis of Androgen Action Is Transcriptional Regulation

1990 • 141 citations

Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line

1991 • 120 citations

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

1991 • 120 citations

Differentiated Functions Expressed by Cultured Mouse Lymphoma Cells

1973 • 117 citations

Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.

1992 • 106 citations

Cyclic AMP-dependent protein kinase promotes glucocorticoid receptor function.

1986 • 97 citations

Genes Newly Identified as Regulated by Glucocorticoids in Murine Thymocytes

1991 • 91 citations

Mutagenesis in S49 mouse lymphoma cells: induction of resistance to ouabain, 6-thioguanine, and dibutyryl cyclic AMP.

1977 • 90 citations

In vivo accumulation of sulfated glycoprotein 2 mRNA in rat thymocytes upon dexamethasone-induced cell death

1991 • 89 citations

Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants.

1984 • 87 citations

A new determinant of glucocorticoid sensitivity in lymphoid cell lines.

1983 • 72 citations

Glucocorticoid action on rat thymic lymphocytes. Experiments utilizing adenosine to support cellular metabolism lead to a reassessment of catabolic hormone actions.

1976 • 71 citations

Tissue-Specific Enhancer of the Human Glycoprotein Hormone α-Subunit Gene: Dependence on Cyclic AMP-Inducible Elements

1987 • 71 citations

DNA fragmentation in S49 lymphoma cells killed with glucocorticoids and other agents

1983 • 66 citations

Protein Serine Threonine Kinases

1987 • 63 citations

Cyclic amp-induced cytolysis in S49 cells: selection of an unresponsive “deathless” mutant

1977 • 53 citations

Ion transport by ouabain resistant and sensitive ehrlich ascites carcinoma cells

1972 • 39 citations

Immunological selection of variant mouse lymphoid cells with altered glucocorticoid responsiveness.

1983 • 35 citations

Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor

1990 • 33 citations

Genetic and Epigenetic Bases of Glucocorticoid Resistance in Lymphoid Cell Lines

1985 • 31 citations

Anti‐CD3‐induced cell death in T cell hybridomas: mitochondrial failure and DNA fragmentation are distinct events

1991 • 27 citations

Glucocorticoid receptors in human leukemias and related diseases

1985 • 24 citations

Down-Regulation of Glucocorticoid Receptors in Mouse Lymphoma Cell Variants

1984 • 24 citations

Coexpression of mutant and wild type protein kinase in lymphoma cells resistant to dibutyryl cyclic AMP

1977 • 24 citations

Transcriptional Transactivation Functions Localized to the Glucocorticoid Receptor N Terminus Are Necessary for Steroid Induction of Lymphocyte Apoptosis

1992 • 21 citations

Glucocorticoid action on rat thymic lymphocytes

1976 • 19 citations

Phenothiazines cause a shift in the cAMP dose-response: Selection of resistant variants in a murine thymoma line

1984 • 19 citations

Immunological Selection of Variant Mouse Lymphoid Cells with Altered Glucocorticoid Responsiveness

1983 • 14 citations

Induction of glucocorticoid-resistant variants in a murine thymoma line by antitumor drugs.

1981 • 14 citations

Be13, a human T-leukemia cell line highly sensitive to dexamethasone-induced cytolysis.

1984 • 14 citations

Combined Therapy With 5-Azacytidine and Hydrocortisone in Glucocorticoid-Sensitive and -Resistant Mouse P1798 Lymphosarcoma1

1988 • 10 citations