Cell death: a new classification separating apoptosis from necrosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease

1973 • 1,176 citations

Death in Embryonic Systems

1966 • 943 citations

Growth Kinetics of Tumours

1978 • 691 citations

Effect of a transient period of ischemia on myocardial cells. II. Fine structure during the first few minutes of reflow.

1974 • 434 citations

Extreme sensitivity of some intestinal crypt cells to X and γ irradiation

1977 • 417 citations

Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ culture

1966 • 364 citations

Ischemic tissue injury.

1975 • 336 citations

An electron‐microscope study of the mode of cell death induced by cancer‐chemotherapeutic agents in populations of proliferating normal and neoplastic cells

1975 • 300 citations

Deletion of cells by apoptosis during castration-induced involution of the rat prostate

1973 • 285 citations

An electron-microscope study of cell deletion in the anuran tadpole tail during spontaneous metamorphosis with special reference to apoptosis of striated muscle fibres

1974 • 238 citations

Cell Death in Morphogenesis

1966 • 232 citations

Atrophy and apoptosis in the cyclical human endometrium

1976 • 192 citations

Prevention by chlorpromazine of ischemic liver cell death.

1977 • 188 citations

The ultrastructure of the adrenal cortex of the rat under normal and experimental conditions

1971 • 184 citations

Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster

1969 • 168 citations

Early, reversible plasma membrane injury in galactosamine-induced liver cell death.

1975 • 163 citations

STUDIES ON NECROSIS OF MOUSE LIVER IN VITRO. ULTRASTRUCTURAL ALTERATIONS IN THE MITOCHONDRIA OF HEPATIC PARENCHYMAL CELLS.

1965 • 162 citations

Irreversible myocardial injury in anoxic perfused rat hearts.

1975 • 160 citations

Hormonal control of apoptosis in hamster uterine luminal epithelium

1979 • 156 citations

Epithelial cell death and cyclic AMP increase during palatal development.

1975 • 152 citations

The mechanism of T cell mediated cytotoxicity II. morphological studies of cell death by time-lapse microcinematography

1976 • 146 citations

Electron microscope study of palate fusion in mouse embryos

1968 • 145 citations

The Macrophage

1973 • 140 citations

The biochemical pathology of liver cell necrosis.

1975 • 136 citations

Structural abnormalities in neurones.

1977 • 132 citations

Ultrastructural study of the normal degeneration of the intersegmental muscles of Antheraea polyphemus and Manduca sexta (Insecta, lepidoptera) with particular reference to cellular autophagy

1977 • 131 citations

CELL DEATH IN THE EMBRYONIC CHICK SPINAL CORD

1974 • 127 citations

Alterations in renal cortex following ischemic injury. 3. Ultrastructure of proximal tubules after ischemia or autolysis.

1972 • 127 citations

Oxygen Diffusion Distance and Development of Necrosis in Multicell Spheroids

1979 • 121 citations

Cell death in the normal neonatal rat adrenal cortex

1973 • 121 citations

Microcinematographic and electron microscopic analysis of target cell lysis induced by cytotoxic T lymphocytes.

1979 • 111 citations

Dynamics of growth in tumors and in normal organisms.

1969 • 109 citations

Cell death and the development of limb form and skeletal pattern in normal andwingless(ws) chick embryos

1973 • 106 citations

Isolation and purification of calcium and magnesium dependent endonuclease from rat liver nuclei

1974 • 102 citations

Ultrastructural changes in the theca interna during follicular atresia in sheep

1978 • 101 citations

Inhibition of palatal epithelial cell death by altered protein synthesis

1976 • 100 citations

A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard, or X-irradiation.

1970 • 99 citations

Myocardial cell death in the embryonic chick ventricle

1969 • 97 citations

Cell death in chick embryos as studied by electron microscopy.

1961 • 97 citations

The Suppressive Role of Mouse Peritoneal Phagocytes in Agglutinin Response

1965 • 90 citations

The pathology of bone marrow transplantation.

1974 • 89 citations

Cellular change in human disease

1973 • 89 citations

Disorders of cell volume regulation. I. Effects of inhibition of plasma membrane adenosine triphosphatase with ouabain.

1968 • 87 citations

Lysosome and phagosome stability in lethal cell injury. Morphologic tracer studies in cell injury due to inhibition of energy metabolism, immune cytolysis and photosensitization.

1972 • 86 citations

Cytolysis induced by human lymphotoxin.

1972 • 85 citations

Colloidal lanthanum as a marker for impaired plasma membrane permeability in ischemic dog myocardium.

1975 • 85 citations

The effects of sodium chromate on the proximal tubules of the rat kidney. Fine structural damage and lysozymuria.

1974 • 84 citations

THE FOETAL ADRENAL CORTEX IN THE HUMAN

1968 • 84 citations

Changes in Small Blood Vessels During Cyclical Luteal Regression in Sheep

1977 • 82 citations

Cellular necrosis in the liver induced and modified by drugs.

1965 • 78 citations

Studies on the pathogenesis of cell injury: effects of inhibitors of metabolism and membrane function on the mitochondria of Ehrlich ascites tumor cells.

1975 • 75 citations

Differential effects of hydroxyurea on survival of proliferating cells in vivo.

1969 • 74 citations

Morphological aspects of glucocorticoid‐induced cell death in human lymphoblastoid cells

1978 • 72 citations

Elevated levels of cAMP alters the effect of epidermal growth factor in vitro on programmed cell death in the secondary palatal epithelium

1977 • 70 citations

Genetic inhibition of mesenchymal cell death and the development of form and skeletal pattern in the limbs oftalpid3(ta3) mutant chick embryos

1974 • 68 citations

A light and electron microscopic study of thermally injured cultured cells.

1972 • 62 citations

Tetrazolium salt and electron-microscopic studies of cellular degeneration and necrosis in the interdigital areas of the developing chick limb

1971 • 59 citations

Light and dark cells as artifacts of liver fixation.

1968 • 59 citations

Analytical electron microscopic study of mitochondrial inclusions in canine myocardial infarcts.

1976 • 59 citations

Inhibitory effect of actinomycin D on tail atrophy inXenopus larvae at metamorphosis

1965 • 57 citations

Early Biochemical Alterations Induced by Lymphotoxin in Target Cells

1973 • 55 citations

Differential Radiation Response Amongst Proliferating Epithelial Cells

1978 • 46 citations

Cell autolysis and deletion in the planarian polycelis tenuis Iijima

1974 • 44 citations

The effects of starvation on the planarian worm Polycelis tenuis iijima

1976 • 44 citations

Cytotoxic activity of lymphocytes. II. Studies on mechanism of lymphotoxin-mediated cytotoxicity.

1972 • 42 citations

Cell death

1976 • 41 citations

Origin and Continuity of Desmosomes

1971 • 40 citations

Structural changes in the freeze-fractured sarcolemma of ischemic myocardium.

1977 • 40 citations

Ion movements in cell injury. Effects of inhibition of respiration and glycolysis on the ultrastructure and function of the epithelial cells of the toad bladder.

1968 • 34 citations

ULTRASTRUCTURAL CHANGES IN LYMPHOCYTES EXPOSED TO NOXIOUS AGENTS IN VITRO

1966 • 31 citations

Protective effects of an inhibitor of protein synthesis, cycloheximide, on bone marrow damage induced by cytosine arabinoside or nitrogen mustard.

1975 • 31 citations

The morphology and pathogenesis of nephrotoxicity following methoxyflurane (penthrane) anesthesia. An experimental model in rats.

1972 • 29 citations

Cell death and autonomous gene action in lethals affecting imaginal discs in Drosophila melanogaster

1974 • 28 citations

Influence of thyroid hormones on neuronal death and differentiation in larval Rana pipiens

1976 • 28 citations

The fine structure of the newborn rat adrenal cortex

1970 • 27 citations

Perturbation of mammalian cell division: III. the topography and kinetics of extrusion subdivision

1976 • 26 citations

Cytotoxic Activity of Lymphocytes

1972 • 24 citations

[Electron microscopic studies on the degradation of the apical ridge during the development of limbs in rat embryos].

1972 • 24 citations

Mammary tumor regression. II. Autophagy of neoplastic cells.

1972 • 22 citations

Another look at rejection in pig liver homografts.

1974 • 21 citations

Das elektronenmikroskopische Bild des Abbaues der epithelialen Scheitelleiste w�hrend der Extremit�tenentwicklung bei Rattenfeten

1972 • 20 citations

Light and electron microscopic studies of the rat kidney after administration of inhibitors of the citric acid cycle in vivo. I. Effects of sodium fluoroacetate on the proximal convoluted tubule.

1972 • 19 citations

Light‐ and electron‐microscope studies of the rat kidney after administration of inhibitors of the citric acid cycle in vivo: Changes in the proximal convoluted tubule during fluorocitrate poisoning

1972 • 17 citations

Electrical Recordings from Meningioma Cells during Cytolytic Action of Antibody and Complement

1967 • 16 citations

Glucocorticoid regulation of rat thymus RNA polymerase activity: The role of RNA and protein synthesis

1978 • 14 citations

DIFFERENTIAL LETHAL EFFECTS OF BOTH CYTOSINE ARABINOSIDE AND HYDROXYUREA ON JEJUNAL CRYPT CELLS AND TESTOSTERONE‐STIMULATED ACCESSORY SEX GLANDS

1979 • 14 citations

Alteratons in RNA synthesis in lymphotoxin-treated target cells.

1975 • 14 citations

An experimental study of necrosis in tumors.

1962 • 13 citations

Cytotoxic activity of lymphocytes

1979 • 12 citations

The autolysis of neonatal pulmonary cells in vitro: An ultrastructural study

1973 • 5 citations

Effect of altering blood flow on necrosis in tumors.

1965 • 4 citations