Chapter 10. Biochemical Mechanism of Glucocorticoid-and Phenytoin-Induced Cleft Palate

Gene Regulation for Higher Cells: A Theory

1969 • 2,022 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Teratology: Principles and Techniques.

1965 • 682 citations

Biochemical actions of hormones

1987 • 588 citations

Glucocorticoid receptors: Relations between steroid binding and biological effects

1972 • 554 citations

Teratology. Principles and Techniques

1965 • 522 citations

Tissue effects of glucocorticoids

1972 • 503 citations

Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle

1973 • 275 citations

Glucocorticoid Receptors in Lymphoma Cells in Culture: Relationship to Glucocorticoid Killing Activity

1971 • 239 citations

Hormone Receptors

1979 • 197 citations

Estrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors.

1979 • 184 citations

THE INHERITANCE OF SUSCEPTIBILITY TO THE TERATOGENIC ACTION OF CORTISONE IN MICE

1954 • 168 citations

Phenytoin teratogenesis: correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue.

1977 • 166 citations

Cleft Palate in the Mouse: A Teratogenic Index of Glucocorticoid Potency

1965 • 159 citations

The Embryology of Cortisone-induced Cleft Palate

1957 • 147 citations

Liver Cytosol Corticosteroid Binder II, a Hormone Receptor

1973 • 142 citations

Studies in Histocompatibility

1981 • 121 citations

Cleft palate susceptibility linked to histocompatibility-2 (H-2) in the mouse

1975 • 120 citations

Some aspects of the H-2 system, the major histocompatibility system in the mouse

1978 • 110 citations

Increased template activity of liver chromatin, a result of hydrocortisone administration.

1965 • 108 citations

Induction of cleft palate in rats with antiinflammatory drugs

1971 • 104 citations

Involvement of Glucocorticoids in the Development of the Secondary Palate

1979 • 103 citations

Glucocorticoid Receptors in Rat Thymocytes

1974 • 97 citations

Influence of the mouse major histocompatibility complex, H-2, on liver adenylate cyclase activity and on glucagon binding to liver cell membranes

1980 • 91 citations

Defect in 3′-phosphoadenosine 5′-phosphosulfate synthesis in brachymorphic mice

1982 • 87 citations

INTERACTION OF HLA MOLECULES WITH NON-IMMUNOLOGICAL LIGANDS AS AN EXPLANATION OF HLA AND DISEASE ASSOCIATIONS

1976 • 87 citations

Palatal cytosol cortisol-binding protein associated with cleft palate susceptibility and H–2 genotype

1977 • 84 citations

CORTISONE-INDUCED CLEFT PALATE IN THE MOUSE. A SEARCH FOR THE GENETIC CONTROL OF THE EMBRYONIC RESPONSE TRAIT

1977 • 82 citations

Some aspects of corticosteroid‐induced cleft palate: A review

1975 • 81 citations

Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids

1980 • 72 citations

Glucocorticoid receptors in murine embryonic facial mesenchyme cells

1976 • 70 citations

Human foetal palatal corticoid receptors and teratogens for cleft palate

1978 • 70 citations

An in vitro and in vivo study of single palatal processes

1972 • 68 citations

Genetic polymorphism of ?2-microglobulin (B2m) maps to the H-3 region of chromosome 2

1981 • 65 citations

On the mechanism of hormone action

1969 • 61 citations

Etiology of Cleft Lip and Cleft Palate.

1983 • 60 citations

Cortexolone: Binding to glucocorticoid receptors in rat thymocytes and mechanism of its antiglucocorticoid action

1972 • 56 citations

Cleft palate following prenatal food restriction in mice: Association with elevated maternal corticosteroids

1977 • 56 citations

Defect in 3′-phosphoadenosine 5′-phosphosulfate synthesis in brachymorphic mice

1982 • 54 citations

Association of mouse liver adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels with histocompatibility-2 genotype.

1975 • 52 citations

Comparison of In Vitro Fluoride Uptake by Human and Bovine Enamel from Acidulated Phosphate-Fluoride Solutions

1974 • 52 citations

Relationships, among the steroids, of anti-inflammatory properties and inhibition of prostaglandin production and arachidonic acid release by transformed mouse fibroblasts.

1977 • 52 citations

Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17.

1981 • 50 citations

Glucocorticoid Inhibition of RNA Synthesis Responsible for Cleft Palate in Mice: A Model

1970 • 49 citations

Inhibition of Programmed Cell Death in Mouse Embryonic Palate in Vitro by Cortisol and Phenytoin: Receptor Involvement and Requirement of Protein Synthesis

1983 • 48 citations

Stabilization and characterization of the dexamethasone-binding proteins in rat liver cytosol

1976 • 45 citations

Spatial relations in the oral cavity of cortisone‐treated mouse fetuses during the time of secondary palate closure

1973 • 41 citations

HLA Antigens and Corticosteroid Response

1976 • 41 citations

Genetic and Environmental Factors in Cortisone Induced Cleft Palate

1978 • 40 citations

H-2 Histocompatibility Region: Influence on the Murine Glucocorticoid Receptor and Its Response

1982 • 39 citations

Hepatic glucocorticoid receptors and the H–2 locus

1978 • 38 citations

Distribution and metabolism of triamcinolone acetonide in inbred mice with different cleft palate sensitivities

1972 • 37 citations

Diphenylhydantoin: An Alternative Ligand of a Glucocorticoid Receptor Affecting Prostaglandin Generation in A/J Mice

1982 • 36 citations

Glucocorticoid inhibition of RNA synthesis and the critical period for cleft palate induction in inbred mice

1973 • 36 citations

A glucocorticoid receptor in fetal mouse: Its relationship to cleft palate formation

1980 • 34 citations

Corticosteroid-induced cleft palate in mice and H-2 haplotype: Maternal and embryonic effects

1981 • 33 citations

Evidence for a Role of Arachidonic Acid in Glucocorticoid-Induced Cleft Palate in Rats

1981 • 32 citations

Ontogeny and biochemical properties of glucocorticoid receptors in mid-gestation mouse embryos

1978 • 32 citations

Prostaglandin synthesis by primary cultures of mouse embryo palate mesenchyme cells

1981 • 31 citations

Further Evidence for a Role of Arachidonic Acid in Glucocorticoid Teratogenic Action in the Palate

1983 • 30 citations

Inhibition of Programmed Cell Death in the Fetal Palate by Cortisol

1981 • 29 citations

The susceptibility to cortisone-induced cleft palate of recombinant inbred strains of mice: lack of association with theH-2haplotype

1981 • 29 citations

Cortisone‐induced cleft palate in the brachymorphic mouse

1981 • 26 citations

Maternal-Fetal Distribution of Radioactive Cortisol and Its Correlation with Teratogenic Effect

1968 • 26 citations

The Biological Function of the Major Histocompatibility Complex: Hypotheses

1980 • 26 citations

Saturable binding of [³H]phenytoin to rat brain membrane fraction

1981 • 25 citations

Influence of H-2-linked genes on glucocorticoid receptors in the fetal mouse palate

1981 • 24 citations

Comparative Teratogenicity of Cortisone and Phenytoin in Mice

1981 • 23 citations

Calmodulin antagonists competitively inhibit dexamethasone binding to the glucocorticoid receptor

1982 • 22 citations

Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3

1983 • 21 citations

Relation of in vivo drug metabolism to stereoselective fetal hydantoin toxicology in mouse: evaluation of mephenytoin and its metabolite, nirvanol.

1982 • 20 citations

The effect of cortisone on the teratogenic action of acetylsalicylic acid and diphenylhydantoin in the mouse

1976 • 19 citations

Estrogen receptor in uteri of mice of differentH-2 genotypes

1979 • 18 citations

An H-2 linked difference in the binding of dexamethasone to murine hepatic cytosol receptor a possible role of endogenous modifier(s)

1981 • 18 citations

Palate development after fetal tongue removal in cortisone‐treated mice

1978 • 17 citations

Effect of cortisol on medial edge epithelium of organ-cultured single palatal shelves from steroid-susceptible mouse strains

1980 • 15 citations

Commercial dietary influences on the frequency of cortisone‐induced cleft palate in C57B1/6J mice

1977 • 15 citations

Abnormal Organogenesis in the Reproductive System

1977 • 14 citations

Differential Binding of 14C-Cortisone in Fetal, Placental, and Maternal Liver Tissue in A/Jax and C57BL Mice

1972 • 14 citations

Occurrence of cleft palate, micrognathia, and agnathia in selected strains of cortisone- and phenytoin-treated mice.

1982 • 14 citations

The endogenous heat-stable glucocorticoid receptor stabilizing factor and the H-2 locus

1982 • 13 citations

Phenytoin Teratogenicity in the Primary and Secondary Mouse Embryonic Palate Is Influenced by the H-2 Histocompatibility Locus

1983 • 12 citations

Genetic control of insulin receptors.

1981 • 11 citations

CLEFT PALATE SUSCEPTIBILITY MAPS IN TWO H‐2 SUBREGIONS, H‐2K TO I‐B AND G TO H‐2D

1982 • 10 citations

Susceptibility of Mice to Phenytoin-Induced Cleft Palate Correlated with Inhibition of Fetal Palatal RNA and Protein Synthesis

1981 • 10 citations

Genetic control of hydrocortisone-induced thymus atrophy

1979 • 10 citations

Palate Morphology and Fetal Movements in Mice After DPH

1979 • 8 citations

[Induction of cleft palate in ball mice: the comparative effect of 5-fluorouracil, phenylbutazone and water and food deprivation (author's transl)].

1976 • 5 citations

Cortisol inhibition of development of various lysosomal enzymes in cultured palatal shelves from mouse embryos

1983 • 3 citations