Insect muscle as a model for programmed cell death

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

1989 • 711 citations

Cell death in the development of the lateral motor column of the chick embryo

1975 • 658 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

Programmed cell death—I. Cytology of degeneration in the intersegmental muscles of the Pernyi silkmoth

1965 • 449 citations

Ubiquitination

1991 • 430 citations

Naturally Occurring Neuronal Death in Vertebrates

1990 • 389 citations

Cell death in normal and rough eye mutants of Drosophila

1991 • 364 citations

Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ culture

1966 • 364 citations

Perspectives on mammalian cell death

1988 • 334 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development

1978 • 318 citations

Regulation of the differentiation of PC12 pheochromocytoma cells.

1989 • 296 citations

Ultrastructural differences during embryonic cell death in normal and peripherally deprived ciliary ganglia.

1976 • 266 citations

Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration

1989 • 266 citations

Anti‐immunoglobulins induce death by apoptosis in WEHI‐231 B lymphoma cells

1990 • 239 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

Hormonal control of rates of metamorphic development in the tobacco hornworm Manduca sexta

1983 • 224 citations

Activation of polyubiquitin gene expression during developmentally programmed cell death

1990 • 214 citations

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

1988 • 201 citations

Antigen-induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*

1989 • 186 citations

Programmed cell death. Activation of lysis by a mechanism involving the synthesis of protein

1969 • 162 citations

Gene activation is required for developmentally programmed cell death.

1990 • 160 citations

Biochemical characterization of programmed cell death in NGF‐deprived sympathetic neurons

1992 • 146 citations

Regulation of the ecdysteroid titer of Manduca sexta: reappraisal of the role of the prothoracic glands.

1988 • 136 citations

Ubiquitin in health and disease

1991 • 135 citations

Ultrastructural study of the normal degeneration of the intersegmental muscles of Antheraea polyphemus and Manduca sexta (Insecta, lepidoptera) with particular reference to cellular autophagy

1977 • 131 citations

Prolactin inhibits both thyroid hormone-induced morphogenesis and cell death in cultured amphibian larval tissues

1991 • 125 citations

Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro

1990 • 103 citations

Biochemical evidence for programmed cell death in rabbit uterine epithelium.

1989 • 95 citations

Peptide and Steroid Regulation of Muscle Degeneration in an Insect

1982 • 93 citations

The role of cell death genes during development

1991 • 86 citations

Rescue of motoneurons from cell death by a purified skeletal muscle polypeptide: Effects of the ChAT development factor, CDF

1990 • 83 citations

Disappearance of Rohon‐Beard neurons from the spinal cord of larval Xenopus laevis

1987 • 81 citations

LYSOSOMAL PACKAGING IN DIFFERENTIATING AND DEGENERATING ANURAN LATERAL MOTOR COLUMN NEURONS

1974 • 78 citations

Normal and Induced Degeneration of Abdominal Muscles during Metamorphosis in the Lepidoptera

1956 • 78 citations

Inclusion bodies in motor cortex and brainstem of patients with motor neurone disease are detected by immunocytochemical localisation of ubiquitin

1989 • 61 citations

Glucocorticoid Endangerment of Hippocampal Neurons Does not Involve Deoxyribonucleic Acid Cleavage

1989 • 60 citations

Programmed cell death: Dying cells synthesize a co‐ordinated, unique set of proteins in two different episodes of cell death

1988 • 57 citations

Characterization and inducibility of hsp 70 proteins in the male mouse germ line.

1990 • 49 citations

Cyclic GMP may serve as a second messenger in peptide-induced muscle degeneration in an insect.

1984 • 43 citations

Programmed cell death. Electrophysiological and ultrastructural correlations in metamorphosing muscles of lepidopteran insects

1979 • 37 citations

Mechanisms for Programmed Cell Death in the Nervous System of a Moth

2007 • 29 citations

Identical populations of phagocytes and dying neurons revealed by intravascularly injected horseradish peroxidase, and by endogenous glutaraldehyde-resistant acid phosphatase, in the brains of chick embryos

1984 • 29 citations

Characterization of a ubiquitin-fusion gene from the tobacco hawkmoth,Manduca sexta

1990 • 22 citations