The role of cell death genes during development

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1951 • 947 citations

Death in Embryonic Systems

1966 • 943 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

1989 • 711 citations

Cell death in the development of the lateral motor column of the chick embryo

1975 • 658 citations

Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein

1960 • 651 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Programmed cell death—I. Cytology of degeneration in the intersegmental muscles of the Pernyi silkmoth

1965 • 449 citations

The neurotrophic theory and naturally occurring motoneuron death

1989 • 397 citations

Naturally Occurring Neuronal Death in Vertebrates

1990 • 389 citations

Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ culture

1966 • 364 citations

Complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells

1975 • 350 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant

1987 • 280 citations

Hormonal control of rates of metamorphic development in the tobacco hornworm Manduca sexta

1983 • 224 citations

Activation of polyubiquitin gene expression during developmentally programmed cell death

1990 • 214 citations

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

1988 • 201 citations

Programmed cell death. Activation of lysis by a mechanism involving the synthesis of protein

1969 • 162 citations

Gene activation is required for developmentally programmed cell death.

1990 • 160 citations

Steroid regulation of neuronal death in the moth nervous system

1984 • 153 citations

Cell death in embryogenesis

1981 • 138 citations

Ultrastructural study of the normal degeneration of the intersegmental muscles of Antheraea polyphemus and Manduca sexta (Insecta, lepidoptera) with particular reference to cellular autophagy

1977 • 131 citations

Peptide and Steroid Regulation of Muscle Degeneration in an Insect

1982 • 93 citations

Rescue of motoneurons from cell death by a purified skeletal muscle polypeptide: Effects of the ChAT development factor, CDF

1990 • 83 citations

Normal and Induced Degeneration of Abdominal Muscles during Metamorphosis in the Lepidoptera

1956 • 78 citations

Cell death in metamorphosis

1981 • 74 citations

Induced metamorphosis in isolated tails ofXenopus larvae

1962 • 72 citations

Programmed cell death: Dying cells synthesize a co‐ordinated, unique set of proteins in two different episodes of cell death

1988 • 57 citations

Regeneration of Neurites on Long-Term Cultures of Sympathetic Neurons Deprived of Nerve Growth Factor

1981 • 40 citations

Characterization of a ubiquitin-fusion gene from the tobacco hawkmoth,Manduca sexta

1990 • 22 citations

Genetic control of cell death in the nematode

1990 • 4 citations