Apoptosis and signal transduction: clues to a molecular mechanism

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis

1991 • 525 citations

Apoptosis: a different type of cell death

1992 • 523 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.

1990 • 485 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Definition and incidence of apoptosis : an historical perspective

1991 • 458 citations

Vitamin D-Dependent Calcium Binding Proteins: Chemistry, Distribution, Functional Considerations, and Molecular Biology*

1989 • 428 citations

Apoptosis: molecular mechanisms in programmed cell death.

1991 • 425 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.

1991 • 359 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.

1989 • 349 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.

1992 • 250 citations

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

1992 • 245 citations

Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

1991 • 244 citations

Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.

1989 • 242 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

1992 • 199 citations

The role of cytosolic Ca2+ in cell injury, necrosis and apoptosis

1992 • 199 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation.

1992 • 190 citations

Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.

1992 • 188 citations

Transcriptional and Transforming Activities of the Adenovirus E1A Proteins

1991 • 187 citations

Properties and physiologic roles of the plasma membrane sodium-hydrogen exchanger.

1986 • 183 citations

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.

1992 • 181 citations

Endonuclease activation during apoptosis: The role of cytosolic Ca2+ and pH

1992 • 179 citations

Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.

1992 • 169 citations

Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.

1992 • 158 citations

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.

1990 • 157 citations

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

1991 • 157 citations

Inhibition of radiation-induced apoptosis in vitro by tumor promoters

1988 • 138 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes.

1992 • 125 citations

Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells

1990 • 119 citations

Protein kinase-C involvement in thymocyte apoptosis induced by hydrocortisone

1990 • 98 citations

Cyclic AMP-dependent protein kinase promotes glucocorticoid receptor function.

1986 • 97 citations

Phorbol esters inhibit apoptosis in IL-2-dependent T lymphocytes

1989 • 95 citations

Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.

1992 • 68 citations

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture.

1992 • 67 citations

Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells

1992 • 65 citations

Subtractive cloning of a hybrid human endogenous retrovirus and calbindin gene in the prostate cell line PC3.

1991 • 61 citations

Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes

1992 • 54 citations

Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1.

1992 • 49 citations

Dexamethasone‐induced killing of neoplastic cells of lymphoid derivation: Lack of early calcium involvement

1990 • 47 citations

Calcium and A23187-induced cytolysis of mouse thymocytes

1980 • 44 citations

Complementation by BCL2 and C-HA-RAS Oncogenes in Malignant Transformation of Rat Embryo Fibroblasts

1990 • 42 citations

Cell cycle kinetics, tissue transglutaminase and programmed cell death (apoptosis)

1992 • 39 citations

Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts.

1990 • 31 citations

The involvement of protein kinase C in activation-induced cell death in T-cell hybridoma

1992 • 26 citations