DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Inhibition of RNA synthesis by actinomycin D: Characteristic dose‐response of different RNA species

1970 • 531 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Perspectives on mammalian cell death

1988 • 334 citations

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

1984 • 195 citations

Immunosuppression in vitro by a metabolite of a human pathogenic fungus.

1984 • 178 citations

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product.

1987 • 167 citations

Gliotoxin induces apoptosis in macrophages unrelated to its antiphagocytic properties.

1988 • 155 citations

The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine

1987 • 147 citations

Inhibition of radiation-induced apoptosis in vitro by tumor promoters

1988 • 138 citations

Identification of an Agent in Cultures of Aspergillus fumigatus Displaying Anti-phagocytic and Immunomodulating Activity in vitro

1985 • 130 citations

Recent Advances in Histopathology

1984 • 127 citations

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ

1987 • 127 citations

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

1988 • 116 citations

Glucocorticoid-induced Lymphocytolysis Is Not Mediated by an Induced Endonuclease

1989 • 94 citations

DEATH OF CELLS BY APOPTOSIS FOLLOWING ATTACHMENT OF SPECIFICALLY ALLERGIZED LYMPHOCYTES IN VITRO

1977 • 93 citations

Apoptosis, lymphocytotoxicity and the containment of viral infections

1985 • 92 citations

Gliotoxin causes oxidative damage to plasmid and cellular DNA.

1988 • 89 citations

DNA Fragmentation in Targets of CTL: An Example of Programmed Cell Death in the Immune System

1985 • 81 citations

Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.

1988 • 78 citations

Glucocorticoid-induced proteins in rat thymus cells.

1981 • 74 citations

Second Cytotoxic Pathway of Diphtheria Toxin Suggested by Nuclease Activity

1989 • 66 citations

AN IMPROVED ASSAY FOR INTERLEUKIN 2 (LYMPHOCYTE GROWTH FACTOR) PRODUCED BY MITOGEN‐ACTIVATED LYMPHOCYTES

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The immunomodulating agent gliotoxin causes genomic DNA fragmentation

1987 • 54 citations

Molecular changes associated with induction of cell death in a human T-cell leukaemia line: Putative nucleases identified as histones

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Actinomycin D-induced breakage of human KB cell DNA

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Mechanisms of Viral Toxicity in Animal Cells

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Gliotoxin-E: A New Biologically-Active Epipolythiodioxopiperazine Isolated From Penicillium terlikowskii

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Alloreactive cytotoxic T cells induce DNA fragmentation in peritoneal macrophages: evidence for target cell killing by cytotoxic T cells in vivo

1989 • 7 citations

Glycogen synthesis in resident and thioglycollate-elicited rat peritoneal exudate cells

1983 • 7 citations