The molecular mechanisms of neuronal apoptosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Excitotoxic cell death

1992 • 2,307 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells

1991 • 810 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

Glutamate triggers internucleosomal DNA cleavage in neuronal cells

1991 • 276 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.

1994 • 251 citations

The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells

1993 • 222 citations

Pro‐oxidants and mitochondrial Ca²⁺: their relationship to apoptosis and oncogenesis

1993 • 218 citations

Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice

1992 • 211 citations

Cell death and the cell cycle: a relationship between transformation and neurodegeneration?

1993 • 205 citations

Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans.

1994 • 204 citations

Expression of the Baculovirus p35 Gene Inhibits Mammalian Neural Cell Death

1993 • 194 citations

Death by suicide: one way to go in mammalian cellular development?

1991 • 167 citations

Peptide growth factors protect against ischemia in culture by preventing nitric oxide toxicity

1993 • 160 citations

The cell cycle and cell death

1993 • 137 citations

Bcl-2 affects survival but not neuronal differentiation of PC12 cells

1993 • 129 citations

Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere

1993 • 73 citations

Oncogene expression in retinal horizontal cells of transgenic mice results in a cascade of neurodegeneration

1993 • 45 citations