MHC Class I Antigens and Immune Surveillance in Transformed Cells

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

NK CELL RECOGNITION

2004 • 2,685 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

CELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO

2005 • 1,108 citations

Human Diversity in Killer Cell Inhibitory Receptor Genes

1997 • 1,052 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Proteolysis: from the lysosome to ubiquitin and the proteasome

2005 • 1,016 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Human tumor antigens recognized by T lymphocytes.

1996 • 860 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1997 • 769 citations

Does the Immune System See Tumors as Foreign or Self?

2003 • 746 citations

Characterization of an Antigen That Is Recognized on a Melanoma Showing Partial HLA Loss by CTL Expressing an NK Inhibitory Receptor

1997 • 746 citations

Cancer--A Biological Approach: I. The Processes Of Control. II. The Significance of Somatic Mutation

1957 • 732 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

Role of MHC Gene Products in Immune Regulation

1981 • 705 citations

Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin.

1953 • 686 citations

T cell defined tumor antigens

1997 • 641 citations

HUMAN T CELL RESPONSES AGAINST MELANOMA

2005 • 638 citations

Antigen processing by the proteasome

2001 • 620 citations

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.

1994 • 584 citations

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes.

1996 • 542 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Loss of Functional Beta2-Microglobulin in Metastatic Melanomas From Five Patients Receiving Immunotherapy

1996 • 515 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

An overview of the MAGE gene family with the identification of all human members of the family.

2001 • 477 citations

MHC class I antigens, immune surveillance, and tumor immune escape

2003 • 475 citations

Immune surveillance against a solid tumor fails because of immunological ignorance

1999 • 463 citations

Natural history of HLA expression during tumour development

1993 • 448 citations

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

2002 • 448 citations

Antigen-processing machinery breakdown and tumor growth

2000 • 444 citations

The killer cell immunoglobulin‐like receptor (KIR) genomic region: gene‐order, haplotypes and allelic polymorphism

2002 • 438 citations

Cross‐presentation: underlying mechanisms and role in immune surveillance

2005 • 435 citations

NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

2002 • 431 citations

Immunoproteasome Assembly: Cooperative Incorporation of Interferon γ (IFN-γ)–inducible Subunits

1998 • 430 citations

Making sense of mass destruction: quantitating MHC class I antigen presentation

2003 • 426 citations

Mechanisms of MHC class I‐restricted antigen processing and cross‐presentation

2005 • 422 citations

THE DETAILED DISTRIBUTION OF HLA-A, B, C ANTIGENS IN NORMAL HUMAN ORGANS

1984 • 410 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Killer immunoglobulin-like receptors

2004 • 402 citations

Reversal of Oncogenesis by the Expression of a Major Histocompatibility Complex Class I Gene

1985 • 375 citations

The host—tumor immune conflict: from immunosuppression to resistance and destruction

1997 • 363 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells

1999 • 355 citations

Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues

2001 • 351 citations

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

1997 • 319 citations

The genetic and antigenic basis of tumour transplantation

1937 • 313 citations

Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.

1991 • 304 citations

MHC antigens and tumor escape from immune surveillance

2001 • 300 citations

Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection

2004 • 299 citations

Major Histocompatibility Complex (MHC) Class I Gene Expression in Single Neurons of the Central Nervous System: Differential Regulation by Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α

1997 • 284 citations

The discovery of MHC restriction

1997 • 281 citations

Immunoreceptor tyrosine-based inhibition motifs

1997 • 279 citations

Multiple Genetic Alterations Cause Frequent and Heterogeneous Human Histocompatibility Leukocyte Antigen Class I Loss in Cervical Cancer

2000 • 270 citations

IFN-γ-induced immune adaptation of the proteasome system is an accelerated and transient response

2005 • 264 citations

HLA class I antigen abnormalities and immune escape by malignant cells

2002 • 264 citations

Defects in the Human Leukocyte Antigen Class I Antigen Processing Machinery in Head and Neck Squamous Cell Carcinoma: Association with Clinical Outcome

2005 • 247 citations

Genes of the Major Histocompatibility Complex in Mouse and Man

1983 • 241 citations

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

1989 • 241 citations

Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA–liposome complexes

1996 • 237 citations

The enigma of the natural killer cell

1995 • 236 citations

Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2?-deoxycytidine treatment

2001 • 234 citations

The innate immune response to tumors and its role in the induction of T‐cell immunity

2002 • 227 citations

Interferon‐γ, the functional plasticity of the ubiquitin–proteasome system, and MHC class I antigen processing

2005 • 226 citations

Expression of Major Histocompatibility Complex class l Molecules on the Different Cell Types in Multiple Sclerosis Lesions

2004 • 226 citations

Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection

1995 • 225 citations

Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis

2005 • 224 citations

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

1990 • 224 citations

Class 1 major histocompatibility complex antigens on human extra-villous trophoblast.

1984 • 224 citations

Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β₂‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association

1988 • 224 citations

Functions of nonclassical MHC and non-MHC-encoded class I molecules

1999 • 211 citations

Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57

2005 • 208 citations

A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer

1996 • 196 citations

beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma.

1998 • 193 citations

DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas

2001 • 191 citations

Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway.

2001 • 189 citations

Variable receptors controlling activation and inhibition of NK cells

2002 • 187 citations

The Major Histocompatibility System in Man and Animals

1977 • 185 citations

The functionality of HLA‐G is emerging

1999 • 177 citations

Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.

1993 • 176 citations

Analysis of HLA-E expression in human tumors

2003 • 173 citations

Distribution of human Class I (HLA-A,B,C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin.

1984 • 168 citations

Deficiency of Transporter for Antigen Presentation (TAP) in Tumor Cells Allows Evasion of Immune Surveillance and Increases Tumorigenesis

1999 • 167 citations

Antigenic Tumor Cell Variants Obtained with Mutagens

1983 • 166 citations

Immunoselective Pressure and Human Leukocyte Antigen Class I Antigen Machinery Defects in Microsatellite Unstable Colorectal Cancers

2005 • 161 citations

Variation Within the Human Killer Cell Immunoglobulin-Like Receptor ( KIR) Gene Family

2002 • 160 citations

HLA-E Protects Glioma Cells from NKG2D-Mediated Immune Responses In Vitro: Implications for Immune Escape In Vivo

2005 • 157 citations

Tumor-induced death of immune cells: its mechanisms and consequences

2002 • 154 citations

Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy

2004 • 152 citations

Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: β₂‐microglobulin inactivation in MSI‐positive tumors and LMP7/TAP2 downregulation in MSI‐negative tumors

2003 • 152 citations

Total loss of MHC class I is an independent indicator of good prognosis in breast cancer

2005 • 146 citations

Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene.

1970 • 144 citations

High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas

1998 • 143 citations

Mutations of the β₂‐microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides

1998 • 142 citations

Further evidence for derepression of H–2 and Ia-like specificities of foreign haplotypes in mouse tumour cell lines

1976 • 138 citations

The Major Histocompatibility System in Man and Animals.

1979 • 136 citations

Alterations of Fas (Apo-1/CD95) Gene in Cutaneous Malignant Melanoma

1999 • 136 citations

Hla Class I Antigens in Human Tumors

1995 • 133 citations

HLA Class I Chromosomal Region, Genes, and Products: Facts and Questions

2017 • 132 citations

Coordinated downregulation of the antigen presentation machinery and HLA class I/β2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer

2004 • 132 citations

Multiple mechanisms underlie HLA dysregulation in cervical cancer

2000 • 129 citations

HLA class I antigen loss, tumor immune escape and immune selection

2002 • 127 citations

Functional Dissociation Between Local and Systemic Immune Response During Anti-Melanoma Peptide Vaccination

1998 • 127 citations

The Detection of Antigenic Differences in Mouse Erythrocytes by the Employment of Immune Sera

1936 • 127 citations

HLA Class I Chromosomal Region, Genes, and Products: Facts and Questions

1994 • 123 citations

Calreticulin and Calnexin Interact with Different Protein and Glycan Determinants During the Assembly of MHC Class I

1998 • 121 citations

High frequency of altered HLA class I phenotypes in invasive breast carcinomas

1996 • 120 citations

Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia.

1989 • 119 citations

Tumour immunology: MHC antigens and malignancy

1986 • 119 citations

Chromosome loss is the most frequent mechanism contributing to HLA haplotype loss in human tumors

1999 • 116 citations

Analysis of HLA expression in human tumor tissues

2003 • 116 citations

HLA Class I Antigen Down-Regulation in Primary Ovary Carcinoma Lesions: Association with Disease Stage

2005 • 115 citations

Constitutive IL-10 Production Accounts for the High NK Sensitivity, Low MHC Class I Expression, and Poor Transporter Associated with Antigen Processing (TAP)-1/2 Function in the Prototype NK Target YAC-1

1998 • 113 citations

Involvement of natural cytotoxicity receptors in human natural killer cell-mediated lysis of neuroblastoma and glioblastoma cell lines

2000 • 112 citations

Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma

2001 • 112 citations

Immunodominance and tumor escape

2002 • 110 citations

The role of the proteasome activator PA28 in MHC class I antigen processing

2002 • 109 citations

Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

2002 • 106 citations

Aberrant DNA methylation in cancer: potential clinical interventions

2002 • 102 citations

Mechanisms of loss of HLA class I expression on colorectal tumor cells

1996 • 102 citations

Loss of major histocompatibility complex-encoded transporter associated with antigen presentation (TAP) in colorectal cancer.

1994 • 100 citations

CD4 T Lymphocytes: A Critical Component of Antitumor Immunity

2005 • 98 citations

HLA class I recognition by killer cell Ig-like receptors

2000 • 97 citations

Complete loss of HLA class I antigen expression on melanoma cells: A result of successive mutational events

2002 • 97 citations

HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas

1999 • 97 citations

High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene

2000 • 97 citations

Immune Selection of Hot-Spot β2-Microglobulin Gene Mutations, HLA-A2 Allospecificity Loss, and Antigen-Processing Machinery Component Down-Regulation in Melanoma Cells Derived from Recurrent Metastases following Immunotherapy

2005 • 96 citations

Sequential Immune Escape and Shifting of T Cell Responses in a Long-Term Survivor of Melanoma

2005 • 94 citations

The TATA box binding protein

1996 • 90 citations

Distribution of HLA class I altered phenotypes in colorectal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

2004 • 89 citations

Loss of interferon-gamma inducibility of TAP1 and LMP2 in a renal cell carcinoma cell line.

2000 • 89 citations

Evolution and Function of the Major Histocompatibility System: Facts and Speculations

1977 • 86 citations

Structure of the HLA class I region and expression of its resident genes

1993 • 85 citations

Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line

1996 • 85 citations

Tumor cell recognition by natural killer cells

2002 • 84 citations

Immunoselection by T lymphocytes generates repeated MHC class I-deficient metastatic tumor variants

2000 • 84 citations

Restoration of the Expression of Transporters Associated with Antigen Processing in Lung Carcinoma Increases Tumor-Specific Immune Responses and Survival

2005 • 81 citations

HLA class I expression in metastatic melanoma correlates with tumor development during autologous vaccination

2006 • 78 citations

Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals

2004 • 77 citations

Epigenetic targets for immune intervention in human malignancies

2003 • 75 citations

Allelic Differences in the Relationship Between Proteasome Activity and MHC Class I Peptide Loading

1998 • 75 citations

Expression of HLA class I and II antigens in bronchogenic carcinomas: its relationship to cellular DNA content and clinical-pathological parameters.

1991 • 74 citations

Tumor aggressiveness and MHC class I and II antigens in laryngeal and breast cancer.

1991 • 71 citations

HLA-DR expression is associated with excellent prognosis in squamous cell carcinoma of the larynx

1990 • 70 citations

Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression.

1992 • 68 citations

EXPRESSION OF CLASS I TRANSPLANTATION ANTIGENS

1986 • 66 citations

Mechanisms of Tumor Evasion

2007 • 66 citations

HLA class I defects in malignant lesions: What have we learned?

2003 • 66 citations

Loss of HLA molecules in B lymphomas is associated with an aggressive clinical course

1998 • 64 citations

Structural and functional analysis of β2 microglobulin abnormalities in human lung and breast cancer

1996 • 64 citations

An immunohistochemical study of altered immunomodulatory molecule expression in head and neck squamous cell carcinoma

1997 • 63 citations

Sequence organisation of the class II region of the human MHC

1999 • 63 citations

MHC class I alleles and their exploration of the antigen‐processing machinery

2005 • 62 citations

Loss of HLA class‐I alleles, heavy chains and β₂‐microglobulin in colorectal cancer

1992 • 61 citations

Immunological ignorance of solid tumors

2005 • 59 citations

Class I and II HLA antigen distribution in normal mucosa, adenoma and colon carcinoma: relation with malignancy and invasiveness.

1987 • 57 citations

Prognostic significance of cytokine modulation in non‐small cell lung cancer

2002 • 56 citations

The biological consequences of altered MHC expression on tumours

1987 • 55 citations

Identification of different tumor escape mechanisms in several metastases from a melanoma patient undergoing immunotherapy

2006 • 55 citations

Characterization of a gastric tumor cell line defective in MHC class I inducibility by both α‐ and γ‐interferon

1996 • 55 citations

Complexity, contradictions, and conundrums: studying post‐proteasomal proteolysis in HLA class I antigen presentation

2005 • 53 citations

LOH at 6p21.3 region and HLA class altered phenotypes in bladder carcinomas

2006 • 53 citations

Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro

1998 • 52 citations

Multiple mechanisms of immune evasion can coexist in melanoma tumor cell lines derived from the same patient

2001 • 50 citations

Biological Implications of HLA‐DR Expression in Tumours

1995 • 50 citations

A new β₂ microglobulin mutation found in a melanoma tumor cell line

1999 • 50 citations

Expression of histocompatibility (HLA) antigens on tumor cells and normal cells from patients with melanoma

1977 • 48 citations

High frequency of altered HLA class I phenotypes in laryngeal carcinomas

2000 • 47 citations

HLA class I phenotype and genotype alterations in cervical carcinomas and derivative cell lines

1998 • 46 citations

Physical and Functional Association of the Major Histocompatibility Complex Class I Heavy Chain α3 Domain with the Transporter Associated with Antigen Processing

1998 • 46 citations

Accessory molecules in the assembly of major histocompatibility complex class I/peptide complexes: how essential are they for CD8⁺ T‐cell immune responses?

2005 • 40 citations

Criteria to define HLA haplotype loss in human solid tumors

2000 • 40 citations

Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells

2002 • 40 citations

Distinct Transcriptional Pathways Regulate Basal and Activated Major Histocompatibility Complex Class I Expression

2003 • 40 citations

Expression of melan-a/MART-1 antigen as a prognostic factor in primary cutaneous melanoma

2001 • 40 citations

A weakly tumorigenic phenotype with high mhc class‐i expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma

1990 • 39 citations

Phenotypic and genetic analysis of HLA class I and HLA-DR antigen expression on human melanomas.

1988 • 39 citations

Molecular analysis of the HLA-A2 antigen loss by melanoma cells SK-MEL-29.1.22 and SK-MEL-29.1.29.

1998 • 38 citations

In vivo and in vitro generation of a new altered HLA phenotype in melanoma-tumour-cell variants expressing a single HLA-class-I allele

1998 • 37 citations

Transcriptional suppression of HLA-B expression by c-Myc is mediated through the core promoter elements

1994 • 36 citations

HLA class I expression in bladder carcinomas

2003 • 35 citations

Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy

2001 • 35 citations

Mutation in the β2m gene is not a frequent event in head and neck squamous cell carcinomas

1999 • 34 citations

High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity

2004 • 33 citations

Low frequency of HLA haplotype loss associated with loss of heterozygocity in chromosome region 6p21 in clear renal cell carcinomas

2004 • 32 citations

Microsatellite Analysis of Microdissected Tumor Cells and 6p High Density Microsatellite Analysis in Head and Neck Squamous Cell Carcinomas with Down-Regulated Human Leukocyte Antigen Class I Expression

2000 • 31 citations

Loss of Human Leukocyte Antigen Expression on Colorectal Tumor Cell Lines

1993 • 31 citations

Heterogeneity of MHC-class-I antigens in clones of methylcholanthrene-induced tumors. Implications for local growth and metastasis

1991 • 30 citations

Influence of class I H-2 gene expression on local tumor growth. Description of a model obtained from clones derived from a solid BALB/c tumor.

1986 • 30 citations

A mutation determining the loss of HLA-A2 antigen expression in a cervical carcinoma reveals novel splicing of human MHC class I classical transcripts in both tumoral and normal cells

2000 • 30 citations

High frequency of HLA-B44 allelic losses in human solid tumors

2003 • 29 citations

Involvement of the chaperone tapasin in HLA-B44 allelic losses in colorectal tumors

2004 • 29 citations

Enhancement and Inhibition of the Growth of Tumor Homoiotransplants by Pretreatment of the Hosts With Various Preparations of Normal and Tumor Tissue<xref ref-type="fn" rid="fn1">²</xref><xref ref-type="fn" rid="fn2">³</xref>

1952 • 28 citations

Loss of heterozygosity in the HLA class I region in human pancreatic cancer

2004 • 27 citations

Loss of heterozygosity, a frequent but a non‐exclusive mechanism responsible for HLA dysregulation in non‐Hodgkin's lymphomas

2004 • 27 citations

A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*0301 allele in a prostate carcinoma cell line

2001 • 26 citations

MHC loss in colorectal tumours: evidence for immunoselection?

1992 • 26 citations

MHC CLASS I AND II ANTIGENS ON GASTRIC CARCINOMAS AND AUTOLOGOUS MUCOSA

1989 • 25 citations

Efficacy and safety of HLA-B7/β-2 microglobulin plasmid DNA/lipid complex (Allovectin-7^®) in patients with metastatic melanoma

2003 • 25 citations

Reconstitution of antigen presentation in HLA class I-negative cancer cells with peptide-β2m fusion molecules

2001 • 24 citations

Alterations in Fas Expression Are Characteristic of, But Not Solely Responsible for, Enhanced Metastatic Competence

2003 • 23 citations

Antigen Processing, Where Tumor-Specific T-Cell Responses Begin

1993 • 19 citations

High level of chromosome 15 aneuploidy in head and neck squamous cell carcinoma lesions identified by FISH analysis: limited value of β2‐microglobulin LOH analysis

2004 • 19 citations

β2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors

2000 • 19 citations

Selection of metastatic tumour phenotypes by host immune systems

1999 • 19 citations

Mechanisms of Tumor Escape from the Immune Response

2002 • 18 citations

HLA Class I and II Expression in Rhabdomyosarcomas

1991 • 17 citations

Mechanisms of Tumor Escape from the Immune Response

2002 • 15 citations

Development of cancer vaccines to activate cytotoxic T lymphocytes

2005 • 14 citations

Reduced expression of MHC class I antigen in human cancer cell lines with defective LMP-7.

2000 • 12 citations

Regulation of Tumor Progression by Anti-Neoplastic T Cell Responses

2004 • 9 citations

Biologic effects of the altered MHS profile on the K36 tumor, a spontaneous leukemia of AKR.

1980 • 7 citations

Differential expression of melanoma-associated antigens and molecules involved in antigen processing and presentation in three cell lines established from a single patient

2004 • 7 citations

Identification of human papillomavirus 16-E6 protein-derived peptides with the potential to generate cytotoxic T-lymphocytes toward human leukocyte antigen-A24+ cervical cancer

2005 • 6 citations

Universities Vie for DOD Software Center

1984 • 5 citations

Invasion and metastasis control: implications for increased therapeutic index of antitumor drugs

1990 • 5 citations

Efficacy and safety of HLA-B7/beta-2 microglobulin plasmid DNA/lipid complex (Allovectin-7�) in patients with metastatic melanoma

2003 • 3 citations

Lack of sufficient B7 expression as a tumor escape mechanism: implications for immunotherapy

2002 • 3 citations

Reconstitution of expression of H-2K region-encoded murine MHC class I glycoproteins in MHC class I-deficient B16BL6 melanoma cells affects the expression and function of antigen-processing machinery

2005 • 3 citations

Activation of MAPK and AKT pathways by BRAF, NRAS and PIK3CA mutations in melanoma

2007 • 1 citations