Tumor-induced death of immune cells: its mechanisms and consequences

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Metalloproteinase-mediated release of human Fas ligand.

1995 • 835 citations

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

1998 • 789 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Inhibition of Fas death signals by FLIPs

1998 • 531 citations

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

1997 • 403 citations

Human lung carcinomas express Fas ligand.

1997 • 395 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance.

2002 • 375 citations

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

1997 • 373 citations

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

1998 • 331 citations

Antitumor effect of locally produced CD95 ligand

1997 • 315 citations

Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients.

1994 • 307 citations

The role of FasL-induced apoptosis in immune privilege

1997 • 262 citations

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

1997 • 259 citations

Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

2000 • 256 citations

Gene transfer of Fas ligand induces tumor regression in vivo

1997 • 247 citations

Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes.

1998 • 238 citations

Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival

2000 • 236 citations

Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis.

1998 • 224 citations

Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes.

1999 • 218 citations

Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells

2000 • 200 citations

Lymphoid infiltration and prognosis in colorectal carcinoma

1984 • 190 citations

Dendritic cells : biology and clinical applications

1999 • 151 citations

Tumor Immunology

1998 • 146 citations

Dendritic Cells: Biology and Clinical Applications

1999 • 139 citations

Human melanoma cells do not express Fas (Apo-1/CD95) ligand.

1999 • 133 citations

Mechanisms Responsible for Signaling and Functional Defects

1998 • 132 citations

Decreased zeta chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma.

2001 • 128 citations

Fas-Mediated Suicide of Tumor-Reactive T Cells Following Activation by Specific Tumor: Selective Rescue by Caspase Inhibition

1999 • 126 citations

Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer

1998 • 122 citations

The role of Fas/FasL in immunosuppression induced by human tumors

1998 • 115 citations

Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer.

1999 • 112 citations

Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma.

2000 • 110 citations

Prognostic relevance of altered Fas (CD95)-system in human breast cancer

2000 • 106 citations

FasL:Fas ratio--a prognostic factor in breast carcinomas.

2000 • 99 citations

Frequency of apoptosis of tumor-infiltrating lymphocytes induced by fas counterattack in human colorectal carcinoma and its correlation with prognosis.

2000 • 99 citations

Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases

1999 • 96 citations

Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events

2000 • 92 citations

Programmed Cell Death as a Mechanism of CD4 and CD8 T Cell Deletion in AIDS: Molecular Control and Effect of Highly Active Anti‐retroviral Therapy

1999 • 91 citations

Constitutive Expression of FasL in Thyrocytes

1998 • 90 citations

Fas Ligand Is Present in Tumors of the Ewing's Sarcoma Family and Is Cleaved into a Soluble Form by a Metalloproteinase

1998 • 84 citations

FasL is more frequently expressed in liver metastases of colorectal cancer than in matched primary carcinomas

1999 • 83 citations

The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma

2000 • 77 citations

Cutting Edge: The Tumor Counterattack Hypothesis Revisited: Colon Cancer Cells Do Not Induce T Cell Apoptosis Via the Fas (CD95, APO-1) Pathway

2000 • 77 citations

Expressions of Fas ligand and other apoptosis-related genes and their prognostic significance in epithelial ovarian neoplasms

2000 • 73 citations

Fas Ligand Expression in Thyroid Carcinomas: A Potential Mechanism of Immune Evasion

1999 • 64 citations

True

2000 • 62 citations

The Fas Counterattack: A Molecular Mechanism of Tumor Immune Privilege

1997 • 61 citations

Fas-Mediated Apoptosis in Ewing's Sarcoma Cell Lines by Metalloproteinase Inhibitors

1999 • 53 citations

Fas and Fas ligand expression in tumor cells and in vascular smooth-muscle cells of colonic and renal carcinomas

1999 • 45 citations

Specific inhibition of lymphocyte blastogenic responses to mitogens by a factor produced by cultured human malignant lymphoma cells.

1974 • 37 citations

Depletion of the Natural Killer Cell Population in the Peritoneum by AK-5 Tumor Cells Overexpressing Fas-Ligand: A Mechanism of Immune Evasion

1998 • 32 citations

Fas (APO-1/CD95) ligand and Fas expression in renal cell carcinomas: Correlation with the prognostic factors

2000 • 27 citations

T Cell Immunity to Tumor Antigens

1998 • 24 citations

Fas (APO-1/CD95) Ligand and Fas Expression in Renal Cell Carcinomas

2000 • 24 citations

Expression of Fas and Fas Ligand and Apoptosis in Tumor-Associated Lymphocytes and in Tumor Cells from Malignant Pleural Effusions

1998 • 20 citations

Tumor-derived Fas ligand induces toxicity in lymphoid organs and plays an important role in successful chemotherapy

2000 • 15 citations