Complete loss of HLA class I antigen expression on melanoma cells: A result of successive mutational events

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1997 • 769 citations

Antigen-processing machinery breakdown and tumor growth

2000 • 444 citations

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

2001 • 347 citations

Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.

1991 • 304 citations

MHC antigens and tumor escape from immune surveillance

2001 • 300 citations

The β2-microglobulin gene is on chromosome 15 and not in the HL-A region

1975 • 274 citations

HLA class I antigen abnormalities and immune escape by malignant cells

2002 • 264 citations

Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells

2000 • 245 citations

Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2?-deoxycytidine treatment

2001 • 234 citations

Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection

1995 • 225 citations

beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma.

1998 • 193 citations

Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway.

2001 • 189 citations

Mutations of the β₂‐microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides

1998 • 142 citations

Chromosome loss is the most frequent mechanism contributing to HLA haplotype loss in human tumors

1999 • 116 citations

Identification of New Melanoma Epitopes on Melanosomal Proteins Recognized by Tumor Infiltrating T Lymphocytes Restricted by HLA-A1, -A2, and -A3 Alleles

1998 • 114 citations

Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens

2000 • 100 citations

Defective death receptor signaling as a cause of tumor immune escape

2002 • 92 citations

Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line

1996 • 85 citations

Immunoselection by T lymphocytes generates repeated MHC class I-deficient metastatic tumor variants

2000 • 84 citations

Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression.

1992 • 68 citations

Molecular strategies to define HLA haplotype loss in microdissected tumor cells

2000 • 61 citations

A Novel Autocrine Pathway of Tumor Escape from Immune Recognition: Melanoma Cell Lines Produce a Soluble Protein That Diminishes Expression of the Gene Encoding the Melanocyte Lineage Melan-A/MART-1 Antigen Through Down-Modulation of Its Promoter

2001 • 59 citations

Stimulation of HLA-A,B,C by IFN-alpha. The derivation of Molt 4 variants and the differential expression of HLA-A,B,C subsets.

1985 • 56 citations

A new β₂ microglobulin mutation found in a melanoma tumor cell line

1999 • 50 citations

Multiple mechanisms of immune evasion can coexist in melanoma tumor cell lines derived from the same patient

2001 • 50 citations

Identification of a new HLA-A*0201-restricted T-cell epitope from the tyrosinase-related protein 2 (TRP2) melanoma antigen

2000 • 49 citations

HLA class I expression and HPV‐16 sequences in premalignant and malignant lesions of the cervix

1993 • 47 citations

Evidence for a shared HLA-A intralocus determinant defined by monoclonal antibody 131.

1985 • 40 citations

Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy

2001 • 35 citations

Biological and clinical developments in melanoma vaccines

2001 • 25 citations

The Interferon Inhibiting Cytokine IK is Overexpressed in Cutaneous T Cell Lymphoma Derived Tumor Cells That Fail to Upregulate Major Histocompatibility Complex Class II Upon Interferon-γ Stimulation

2001 • 21 citations

Loss of single HLA Class I allospecificities in melanoma cells due to selective genomic abbreviations

2002 • 20 citations