The innate immune response to tumors and its role in the induction of T‐cell immunity

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

1975 • 1,308 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

2001 • 1,190 citations

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

1998 • 1,134 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Regulation of Cutaneous Malignancy by γδ T Cells

2001 • 945 citations

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

2001 • 937 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages

2000 • 864 citations

Natural killer cells, viruses and cancer

2001 • 859 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells

1975 • 844 citations

MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells

1992 • 805 citations

A second lineage of mammalian major histocompatibility complex class I genes.

1994 • 779 citations

Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

1999 • 758 citations

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

2001 • 757 citations

Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells

1995 • 735 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

CD27 is required for generation and long-term maintenance of T cell immunity

2000 • 726 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

1998 • 719 citations

Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice

2000 • 694 citations

The Role of the NKG2D Immunoreceptor in Immune Cell Activation and Natural Killing

2002 • 634 citations

Occurrence of malignancy in immunodeficiency diseases: A literature review

1971 • 621 citations

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumorin vivo

2001 • 588 citations

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

1995 • 575 citations

Molecular Cloning of NKp46: A Novel Member of the Immunoglobulin Superfamily Involved in Triggering of Natural Cytotoxicity

1998 • 562 citations

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

2000 • 540 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

Regulation of the Natural Killer Cell Receptor Repertoire

2001 • 531 citations

Role of NK cells in tumour growth and metastasis in beige mice

1980 • 524 citations

p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation

1997 • 518 citations

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis

2001 • 499 citations

Mouse CD94/NKG2A Is a Natural Killer Cell Receptor for the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule Qa-1b

1998 • 491 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

MHC Class I Deficiency: Susceptibility to Natural Killer (NK) Cells and Impaired NK Activity

1991 • 474 citations

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

2002 • 447 citations

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.

1996 • 441 citations

NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily

1999 • 437 citations

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

1991 • 430 citations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

1991 • 419 citations

In vivonatural killer cell activities revealed by natural killer cell-deficient mice

2000 • 406 citations

IMMUNOLOGICAL ASPECTS OF MALIGNANT DISEASE

1967 • 360 citations

Induction of tumor-specific T cell memory by NK cell–mediated tumor rejection

2001 • 349 citations

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

2000 • 348 citations

Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer

1995 • 338 citations

Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin

2001 • 329 citations

Tumor Development after 3-Methylcholanthrene in Immunologically Deficient Athymic-Nude Mice

1974 • 328 citations

Cutting Edge: NKG2D Receptors Induced by IL-15 Costimulate CD28-Negative Effector CTL in the Tissue Microenvironment

2001 • 318 citations

Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells

1989 • 296 citations

Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor

1993 • 280 citations

UL16-Binding Proteins, Novel MHC Class I-Related Proteins, Bind to NKG2D and Activate Multiple Signaling Pathways in Primary NK Cells

2002 • 272 citations

The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 • 271 citations

Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice.

1991 • 269 citations

The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes.

1979 • 268 citations

Recognition of the Class Ib Molecule Qa-1b by Putative Activating Receptors Cd94/Nkg2c and Cd94/Nkg2e on Mouse Natural Killer Cells

1999 • 233 citations

Dap10 and Dap12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells

2000 • 232 citations

The Molecular and Functional Characterization of a Dominant Minor H Antigen, H60

1998 • 231 citations

Control of lymphocyte function through CD27–CD70 interactions

1998 • 219 citations

Strategies for target cell recognition by natural killer cells

2001 • 212 citations

In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.

1994 • 196 citations

Immunity against cancer: lessons learned from melanoma

2001 • 190 citations

Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity.

1987 • 181 citations

Evidence for Increased Somatic Cell Mutations at the Glycophorin A Locus in Atomic Bomb Survivors

1987 • 180 citations

A reassessment of the role of B7-1 expression in tumor rejection.

1995 • 178 citations

Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.

1993 • 178 citations

YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage.

1985 • 171 citations

Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice

1980 • 165 citations

A Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2–q25.3

2002 • 156 citations

A murine T lymphocyte antigen belongs to a supergene family of type II integral membrane proteins.

1989 • 139 citations

Hla Class I Antigens in Human Tumors

1995 • 133 citations

CD27-Mediated Activation of Murine NK Cells

2000 • 133 citations

MurineNkg2dandCd94are clustered within the natural killer complex and are expressed independently in natural killer cells

1998 • 128 citations

NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity.

1995 • 125 citations

Cloning of a mouse homolog of CD94 extends the family of C‐type lectins on murine natural killer cells

1997 • 122 citations

Cutting Edge: KAP10, a Novel Transmembrane Adapter Protein Genetically Linked to DAP12 but with Unique Signaling Properties

1999 • 115 citations

Chemical Carcinogenesis in Nude Mice: Comparison Between Nude Mice From Homozygous Matings and Heterozygous Matings and Effect of Age and Carcinogen Dose<xref ref-type="fn" rid="fn2">2</xref>

1979 • 103 citations

Genomic Structures and Characterization of Rael Family Members Encoding GPI-Anchored Cell Surface Proteins and Expressed Predominantly in Embryonic Mouse Brain

1996 • 96 citations

Isolation and Characterization of Retinoic Acid-Inducible cDNA Clones in F9 Cells: A Novel cDNA Family Encodes Cell Surface Proteins Sharing Partial Homology with MHC Class I Molecules

1996 • 90 citations

Molecular cloning and characterization of a novel murine T cell surface antigen, YE1/48.

1989 • 83 citations

Increased expression of CD80, CD86 and CD70 on T cells from HIV‐infected individuals upon activation in vitro: regulation by CD4⁺ T cells

1996 • 74 citations

In vitro NK‐activity and in vivo resistance to leukemia: Studies of beige, beige/nude and wild‐type hosts on C57BL background

1980 • 69 citations

Susceptibility to Natural Killer Cell-Mediated Cytolysis Is Independent of the Level of Target Cell Class I HLA-A Expression1

2015 • 66 citations

Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.

1993 • 65 citations

Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants.

1990 • 60 citations

Elevated Frequency of Glycophorin A Mutations in Erythrocytes from Chernobyl Accident Victims

1995 • 58 citations

H-2Kb antigen expression has no effect on natural killer susceptibility and tumorigenicity of a murine hepatoma.

1988 • 52 citations

Susceptibility to natural killer cell-mediated cytolysis is independent of the level of target cell class I HLA expression.

1989 • 49 citations

Natural killer susceptibility is independent of HLA class I antigen expression on cell lines obtained from human solid tumors

1990 • 46 citations

Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells

1998 • 45 citations

PHENOTYPIC MODULATION OF HODGKIN AND REED-STERNBERG CELLS BY EPSTEIN-BARR VIRUS

1996 • 35 citations

Ligands for murine NKG2D display heterogeneous binding behavior

2002 • 32 citations

Development of a flow-cytometric HLA-A locus mutation assay for human peripheral blood lymphocytes

1992 • 29 citations

A Novel Secreted Tumor Antigen with a Glycosylphosphatidylinositol-Anchored Structure Ubiquitously Expressed in Human Cancers

2001 • 29 citations

Spontaneous Tumors in Nude Mice: Effect of the Viable Yellow Gene

1979 • 26 citations

Immunodeficiency states and related malignancies

1997 • 23 citations

Ability of Nude Mice to Generate Alloreactive, Xenoreactive and H-2-Restricted Cytotoxic T-Lymphocyte Responses

1984 • 13 citations

NK-Mediated Elimination of Mutant Lymphocytes that Have Lost Expression of MHC Class I Molecules

2000 • 10 citations