Making sense of mass destruction: quantitating MHC class I antigen presentation

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

2002 • 4,069 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

2001 • 2,167 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

2003 • 737 citations

Phagosomes are competent organelles for antigen cross-presentation

2003 • 701 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

2000 • 634 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

Antigen processing by the proteasome

2001 • 620 citations

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

2000 • 574 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter

1993 • 556 citations

A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes

1997 • 528 citations

An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

2002 • 518 citations

Quantitating Protein Synthesis, Degradation, and Endogenous Antigen Processing

2003 • 508 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues

2002 • 486 citations

Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?

1996 • 440 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

In vivo newly translated polypeptides are sequestered in a protected folding environment

1999 • 333 citations

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

2001 • 322 citations

Linkage between ATP Consumption and Mechanical Unfolding during the Protein Processing Reactions of an AAA+ Degradation Machine

2003 • 309 citations

Peptide Diffusion, Protection, and Degradation in Nuclear and Cytoplasmic Compartments before Antigen Presentation by MHC Class I

2003 • 298 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation.

1988 • 293 citations

Recycling MHC class I molecules and endosomal peptide loading

1999 • 290 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

Dynamics of proteasome distribution in living cells

1997 • 269 citations

Two new proteases in the MHC class I processing pathway

2000 • 253 citations

ATP Hydrolysis by the Proteasome Regulatory Complex PAN Serves Multiple Functions in Protein Degradation

2003 • 248 citations

Detecting and Measuring Cotranslational Protein Degradation in Vivo

2000 • 247 citations

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

2001 • 247 citations

Proteins Are Unfolded on the Surface of the ATPase Ring before Transport into the Proteasome

2001 • 235 citations

An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope

2003 • 231 citations

Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β₂‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association

1988 • 224 citations

Disulfide Bond Isomerization and the Assembly of MHC Class I-Peptide Complexes

2002 • 223 citations

Mutant PrP Is Delayed in Its Exit from the Endoplasmic Reticulum, but Neither Wild-type nor Mutant PrP Undergoes Retrotranslocation Prior to Proteasomal Degradation

2003 • 222 citations

Peptide size selection by the major histocompatibility complex-encoded peptide transporter.

1994 • 212 citations

Newly Synthesized Human δ Opioid Receptors Retained in the Endoplasmic Reticulum Are Retrotranslocated to the Cytosol, Deglycosylated, Ubiquitinated, and Degraded by the Proteasome

2001 • 206 citations

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice

2000 • 192 citations

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

1996 • 174 citations

TAP‐translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin

1997 • 171 citations

The Cytosolic Endopeptidase, Thimet Oligopeptidase, Destroys Antigenic Peptides and Limits the Extent of MHC Class I Antigen Presentation

2003 • 156 citations

Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences.

1995 • 155 citations

The SCF Ubiquitin Ligase

2002 • 153 citations

PMP22 Accumulation in Aggresomes: Implications for CMT1A Pathology

1999 • 152 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

Export of Antigenic Peptides from the Endoplasmic Reticulum Intersects with Retrograde Protein Translocation through the Sec61p Channel

2000 • 151 citations

Neurons Promote the Translocation of Peripheral Myelin Protein 22 into Myelin

1997 • 148 citations

Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase

2001 • 147 citations

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

2001 • 147 citations

Tripeptidyl peptidases: enzymes that count

1999 • 145 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

A Proteasome Howdunit

2000 • 129 citations

Intracellular transport of membrane glycoproteins: two closely related histocompatibility antigens differ in their rates of transit to the cell surface.

1985 • 127 citations

Efficiency of MHC class I antigen processing: A quantitative analysis

1994 • 121 citations

Constitutive Display of Cryptic Translation Products by MHC Class I Molecules

2003 • 112 citations

Antigen Loading of MHC Class I Molecules in the Endocytic Tract

2001 • 108 citations

Human Bleomycin Hydrolase: Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization

1996 • 107 citations

Cutting Edge: Neosynthesis Is Required for the Presentation of a T Cell Epitope from a Long-Lived Viral Protein

2001 • 101 citations

Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.

1993 • 95 citations

Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity

2002 • 91 citations

At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules

2001 • 90 citations

Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

2001 • 85 citations

Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides

1998 • 64 citations

26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate

1999 • 63 citations

Orchestrating nuclear functions: ubiquitin sets the rhythm

2003 • 61 citations

Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase

1990 • 57 citations

Quantifying Recruitment of Cytosolic Peptides for HLA Class I Presentation: Impact of TAP Transport

2003 • 56 citations

Protein disulfide isomerase is the dominant acceptor for peptides translocated into the endoplasmic reticulum

1997 • 54 citations

Prolyl aminopeptidase from rat brain and kidney

1990 • 53 citations

Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity

1987 • 52 citations

Powering the peptide pump: TAP crosstalk with energetic nucleotides

2002 • 52 citations

Association of the thyrotropin receptor with calnexin, calreticulin and BiP

2002 • 50 citations

Proteasome activity limits the assembly of MHC class I molecules after IFN-gamma stimulation.

1997 • 46 citations

Tumor Antigens and Proteomics from the Point of View of the Major Histocompatibility Complex Peptides

2003 • 46 citations

Assembly and Dissociation of Human Leukocyte Antigen (HLA)-A2 Studied by Real-Time Fluorescence Resonance Energy Transfer

2000 • 31 citations

Turnover of nascent proteins in HeLa-S3 cells and the quasi-linear incorporation kinetics of amino acids

1985 • 11 citations

Protein turnover in relation to growth status and the cell cycle in cultured mammalian cells.

1989 • 4 citations