Antigenic Tumor Cell Variants Obtained with Mutagens

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Biology of the Laboratory Mouse

1967 • 1,382 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

Biology of the Laboratory Mouse

1941 • 826 citations

Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.

1960 • 736 citations

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

1976 • 726 citations

A highly polymorphic locus in human DNA.

1980 • 716 citations

Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes

1974 • 572 citations

On the nature of hereditable variation in cultured somatic cells

1976 • 497 citations

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO

1974 • 488 citations

Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2

1974 • 484 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.

1975 • 454 citations

Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.

1976 • 442 citations

Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis.

1977 • 400 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

Surface Antigens Common to Mouse Cleavage Embryos and Primitive Teratocarcinoma Cells in Culture

1973 • 330 citations

Immunodepression and Malignancy

1976 • 310 citations

The role of the reticuloendothelial system in the host reaction to neoplasia

1962 • 295 citations

Antigenic Properties of Lymphomas Induced by the Moloney Agent<xref ref-type="fn" rid="FN2">2</xref>

1964 • 286 citations

Teratomas and differentiation

1975 • 252 citations

Cell surface antigens of human malignant melanoma. II. Serological typing with immune adherence assays and definition of two new surface antigens.

1976 • 238 citations

VIRAL ONCOLYSIS: INCREASED IMMUNOGENICITY OF HOST CELL ANTIGEN ASSOCIATED WITH INFLUENZA VIRUS

1967 • 234 citations

IMMUNOLOGICAL FACTORS IN THE PROCESS OF CARCINOGENESIS

1964 • 232 citations

Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma.

1977 • 231 citations

Quantitation and Cloning of Cytolytic T Lymphocytes and their Precursors

1980 • 213 citations

Biological markers of neoplasia: Basic and applied aspects

1979 • 206 citations

PARASEXUAL APPROACHES TO THE GENETICS OF MAN

1975 • 203 citations

Common human melanoma-associated antigen(s) detected by monoclonal antibodies.

1980 • 200 citations

H-2 Mutations: Their Genetics and Effect on Immune Functions

1978 • 200 citations

Serological analysis of cell surface antigens of malignant human brain tumors

1978 • 191 citations

Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity.

1976 • 175 citations

Cell surface antigens of human renal cancer defined by autologous typing.

1979 • 165 citations

Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. II. T lymphocyte-mediated cytolysis.

1980 • 162 citations

Antitumor Activity of Corynebacterium Parvum

1978 • 148 citations

Rejection by syngeneic mice of cell variants obtained by mutagenesis of a malignant teratocarcinoma cell line.

1977 • 147 citations

Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene.

1970 • 144 citations

The Choice of Animal Tumors for Experimental Studies of Cancer Therapy

1978 • 143 citations

Protection against a nonimmunogenic mouse leukemia by an immunogenic variant obtained by mutagenesis.

1982 • 143 citations

Tumour-associated transplantation antigens of chemically induced sarcomata cross reacting with allogeneic histocompatibility antigens

1975 • 143 citations

Chemical Mutagenesis at the Phosphoribosyltransferase Locus in Cultured Human Lymphoblasts

1972 • 140 citations

Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice.

1980 • 129 citations

Cloned T-Cell Lines with Specific Cytolytic Activity

1979 • 127 citations

IMMUNOLOGICAL ALTERNATION OF LEUKEMIC CELLS In Vivo AFTER TREATMENT WITH AN ANTITUMOR DRUG

1970 • 121 citations

Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.

1977 • 120 citations

T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases.

1981 • 118 citations

Regulatory Mechanisms in the Immune Response to Cell-surface Antigens

1977 • 118 citations

In Vitro Induction of Cytotoxicity against Syngeneic Mastocytoma and Its Suppression by Spleen and Thymus Cells from Tumor-Bearing Mice

1976 • 118 citations

Clones of alloreactive T cells

1978 • 115 citations

Cell‐mediated reaction against tumors induced by oncornaviruses. I. Kinetics and specificity of the immune response in Murine sarcoma virus (MSV)‐induced tumors and transplanted lymphomas

1972 • 107 citations

Mechanism of tumor cell resistance to lysis by syngeneic lymphocytes.

1977 • 106 citations

T-cell lines which cooperate in generation of specific cytolytic activity

1979 • 105 citations

Tumour‐specific immunity against spontneous rat tumours

1966 • 104 citations

Interleukin-2 Dependent Culture of Cytolytic T Cell Lines

1981 • 102 citations

Biochemical polymorphisms in feral and inbred mice (Mus musculus)

1971 • 101 citations

Chromosomal assignment of the mouse kappa light chain genes.

1979 • 99 citations

Tumor Progression and Homeostasis

1976 • 98 citations

H‐2 Restricted Cytolytic and Noncytolytic T Cell Clones: Isolation, Specificity and Functional Analysis

1981 • 95 citations

Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. III. Clonal analysis of the syngeneic cytolytic T lymphocyte response

1982 • 89 citations

Teratocarcinoma cell variants rejected by syngeneic mice: protection of mice immunized with these variants against other variants and against the original malignant cell line.

1978 • 88 citations

H–2 region product as determinant in immune cytolysis of syngeneic tumour cells by anti-MSV T lymphocytes

1976 • 87 citations

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

1975 • 84 citations

Killer T cells in a Burkitt's lymphoma biopsy

1975 • 84 citations

Mutagen treatment as a means for selecting immunogenic variants from otherwise poorly immunogenic malignant murine tumors.

1983 • 83 citations

IN VITRO INDUCTION OF TUMOR-SPECIFIC IMMUNITY

1973 • 83 citations

Modification of tumor regression by immunologic means.

1969 • 79 citations

Relationship of Tumor Immunogenicity to Concentration of the Oncogen2

1975 • 79 citations

Modification in Growth of Transplantable Rat Tumors Exposed to Friend Virus

1969 • 77 citations

Bcg in Tumor Immunotherapy

1978 • 76 citations

Variants of Mouse Myeloma Cells That Produce Short Immunoglobulin Heavy Chains

1974 • 76 citations

Immunologic studies of membrane mutants of a highly metastatic murine tumor.

1979 • 74 citations

The augmentation of in vitro and in vivo tumor-specific T cell-mediated immunity by amplifier T lymphocytes.

1980 • 73 citations

Antigenic changes of L1210 leukemia in mice treated with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide.

1972 • 71 citations

Tumor progression in metastasis: an experimental approach using lectin resistant tumor variants

1982 • 67 citations

Antigenicity of L1210 leukemic sublines induced by drugs.

1972 • 66 citations

Escape of metastasizing clonal tumor cell variants from tumor-specific cytolytic T lymphocytes.

1981 • 64 citations

Inhibition of Transplanted Rat Tumors by Immunization With Identical Tumor Cells Infected With Friend Virus

1970 • 62 citations

Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. IV. Analysis of variant‐specific antigens by selection of antigen‐loss variants with cytolytic T cell clones

1982 • 59 citations

Induction of immune responsiveness in a genetically low-responsive tumor-host combination by chemical modification of the immunogen

1976 • 56 citations

Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens.

1980 • 55 citations

Antigenic specificity of the cytolytic T lymphocyte (CTL) response to murine sarcoma virus-induced tumors. II. Analysis of the clonal progeny of CTL precursors stimulated in vitro with syngeneic tumor cells.

1980 • 54 citations

Tumor cell variants obtained by mutagenesis of a Lewis lung carcinoma cell line: immune rejection by syngeneic mice.

1979 • 54 citations

Development of tumor cell resistance to syngeneic cell-mediated cytotoxicity during growth of ascitic mastocytoma P815Y.

1977 • 54 citations

Antigenic Changes of L5178Y Lymphoma After Treatment With 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide In Vivo 2

1976 • 52 citations

Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells.

1981 • 52 citations

Drug-Mediated Antigenic Changes in Murine Leukemia Cells: Antagonistic Effects of Quinacrine, an Antimutagenic Compound23

1980 • 51 citations

Karyotypic normalcy and quasi-normalcy of developmentally totipotent mouse teratocarcinoma cells

1978 • 50 citations

Cellular immune response to a drug-treated L5178Y lymphoma subline

1974 • 49 citations

Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice X. Immunoselection of tumor variants differing in tumor antigen expression and metastatic capacity

1980 • 47 citations

Chromosome assignment of the tumor-specific antigen of a 3-methylcholanthrene-induced mouse sarcoma.

1981 • 46 citations

INDUCTION AND ANALYSIS OF GENE MUTATIONS IN CULTURED MAMMALIAN SOMATIC CELLS

1974 • 46 citations

Augmented Immunogenicity of Tumor Cell Homogenates Infected with Influenza Virus

1974 • 46 citations

Recognition and genetic control of helper determinants for cell surface antigen Thy–1

1978 • 44 citations

Tumor Antigens on Neoplasms Induced by Chemical Carcinogens and by DNA- and RNA-Containing Viruses: Properties of the Solubilized Antigens

1980 • 43 citations

IN VITRO GENERATION OF PRIMARY CYTOTOXIC LYMPHOCYTES AGAINST L5178Y LEUKEMIA ANTIGENICALLY ALTERED BY 5-(3,3'-DIMETHYL-l-TRIAZENO)-IMIDAZOLE-4-CARBOXAMIDE IN VIVO

1979 • 41 citations

Drug-mediated immunogenic changes of virus-induced leukemia in vivo.

1976 • 41 citations

Naturally Arising Tumors of the Inbred WAB/Not Rat Strain. II. Immunogenicily of Transplanted Tumors<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 41 citations

In vitro generation of a highly immunogenic subline of L1210 leukemia following exposure to 5-(3,3'-dimethyl-1-triazeno)imidazole-4-carboxamide.

1981 • 40 citations

Dissociated and Reconstituted Subcellular Alloantigen Capable of Stimulating Mouse Cytotoxic T Lymphocytes in Vitro

1978 • 38 citations

Selection for high immunogenicity in drug-resistant sublines of murine lymphomas demonstrated by plaque assay.

1975 • 36 citations

Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. VI. Occasional escape from host rejection due to antigen‐loss secondary variants

1983 • 32 citations

Drug Induced Modulation of Immune Responses in Mice: Effects of 5-(3,3-Dimethyl-1-Triazeno)-Imidazole-4-Carboxamide (DTIC) and Cyclophosphayide (CY)

1978 • 30 citations

Brief Communication: Increased Immunogenicity of Two Lymphoma Lines After Drug Treatment of Athymic (Nude) Mice

1975 • 30 citations

Limiting dilution analysis of alloantigen-reactive T lymphocytes. III. Effect of priming on precursor frequencies.

1979 • 29 citations

Differential tumor immunogenicity of L1210 and its sublines. I. Effect of an increased antigen density on tumor cell surfaces on primary B cell responses in vitro.

1977 • 28 citations

Separation of the tumor rejection antigen (TSTA) from the major viral structural proteins associated with the membrane of an R‐MuLV‐induced leukemia

1978 • 28 citations

Antigenic differences between leukemia L1210 and a subline resistant to methylglyoxal-bis(guanylhydrazone).

1972 • 26 citations

Intracerebral Adoptive Immunotherapy of a Murine Lymphoma Antigenically Altered by Drug Treatment In Vivo<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

1982 • 26 citations

GROWTH AND REJECTION PATTERNS OF MURINE LYMPHOMA CELLS ANTIGENICALLY ALTERED FOLLOWING DRUG TREATMENT IN VIVO

1978 • 25 citations

IMMUNITY TO TRANSPLANTABLE TUMORS FOLLOWING VIRAL ONCOLYSIS. I. MECHANISM OF IMMUNITY TO EHRLICH ASCITES TUMOR.

1964 • 25 citations

The Antigenic Structure and Genetic Behaviour of a Transplanted Leukosis

1955 • 25 citations

A Comparative Study of Transplantability of Eight Mammary Gland Tumors Arising in Inbred Mice

1932 • 25 citations

Adoptive immunotherapy in BALB-c times DBA-2 Cr F1 mice bearing an immunogenic subline of L1210 leukemia.

1974 • 25 citations

Tumor-specific immunity induced by somatic hybrids. II. Elicitation of enhanced immunity against the parent plasmacytoma.

1979 • 24 citations

Expression of New Antigens by HL-A Variants of Cultured Lymphoid Cells

1974 • 24 citations

Demonstration of a correlation between tumor cell H-2 antigen content, immunogenicity, and tumorigenicity using lectin-resistant tumor variants.

1981 • 24 citations

<italic>Brief Communication:</italic> Inhibition of Metastasis in Rats Immunized With Xenogenized Autologous Tumor Cells After Excision of the Primary Tumor<xref ref-type="fn" rid="fn2">2</xref>

1975 • 23 citations

Number of Mouse Histocompatibility Genes Involved in Skin Grafting from Strain BALB/cAn to Strain DBA/2

1958 • 23 citations

Changes of the immunogenic properties of a radiation-induced mouse lymphoma following treatment with antitumor drugs.

1975 • 23 citations

Regulation of the immune response to tumor antigen

1980 • 23 citations

Limiting Dilution Analysis of Alloantigen-Reactive T Lymphocytes

1979 • 22 citations

Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. V. H‐2 associativity of variant‐specific antigens

1982 • 22 citations

Reduction of Transplantability of Novikoff Hepatoma Cells Grown <italic>In Vitro</italic> and the Consequent Protecting Effect to the Host Against Their Malignant Progenitor<xref ref-type="fn" rid="FN1">2</xref>

1960 • 22 citations

Frequency and cross-reactivity od cytolytic T lymphocyte precursors reacting against male alloantigens.

1982 • 20 citations

IMMUNOTHERAPY OF EXPERIMENTAL CANCER AS A GUIDE TO THE TREATMENT OF HUMAN CANCER

1976 • 18 citations

Differential Tumor Immunogenicity of DBA/2 Mouse Lymphoma L1210 and Its Sublines. II. Increased Expression of Tumor-Associated Antigens on Subline Cells Recognized by Serologic and Transplantation Methods<xref ref-type="fn" rid="FN2">2</xref>

1979 • 18 citations

Differential Tumor Immunogenicity of L1210 and its Sublines

1977 • 17 citations

In vitro lymphocyte stimulation and the generation of cytotoxic lymphocytes with drug-induced antigenic lymphomas.

1978 • 16 citations

Secondary Cytotoxic Response In Vitro Against Moloney Lymphoma Cells Antigenically Altered by Drug Treatment In Vivo

1978 • 15 citations

Induction of tumor cell rejection in the low responsive YAC-lymphoma strain A host combination by immunization with somatic cell hybrids

1979 • 15 citations

Changes of the immunogenic properties of K36 lymphoma treated in vivo with 5(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC)

1979 • 15 citations

Chemotherapy and immunotherapy of L1210 leukemic mice with antigenic tumor sublines.

1981 • 15 citations

Tumor-Specific Immunity Induced by Somatic Hybrids

1979 • 14 citations

Stimulation of cytolytic T lymphocytes by azaguanine-resistant mouse tumor cells in selective HAT medium

1981 • 13 citations

Expression of type C viral glycoproteins on P815 cells: higher expression of Mr 70,000 glycoprotein-containing glycoprotein on immunogenic variants.

1982 • 12 citations

Increased immunosensitivity in nitrogen mastard-resistant Yoshida sarcoma.

1973 • 12 citations

Immunity to Transplantable Tumors Following Viral Oncolysis

1964 • 11 citations

Immunogenic cell variants of a mouse teratocarcinoma confer a protection against the original non-immunogenic transplantable tumor

1981 • 10 citations

Immunogenic variants obtained by mutagenesis of mouse lewis lung carcinoma. Recognition of variant-specific antigens by cytolytic T lymphocytes

1982 • 9 citations

Immunologic Cross-Reactivity of Antigen(s) Induced by Drug Treatment in Two Leukemic Sublines

1976 • 8 citations

Stability of transplanted murine tumour systems after storage of cells at -196°C for up to 13 years

1978 • 7 citations

Expression of normal histocompatibility antigens in murine lymphomas treated with 5-(3,3′-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) in vivo

1981 • 7 citations

Antigenic properties of lymphoma sublines derived from a drug-treated immunogenic L5178Y leukemia.

1978 • 6 citations

Differential expression of murine leukemia antigen on L1210 parental and drug-resistant sublines.

1981 • 5 citations

EVALUATION OF ANTILEUKEMIC AGENTS IN THE TREATMENT OF DRUG RESISTANT VARIANTS OF LEUKEMIA L1210.

1963 • 3 citations

Rejection of drug-treated tumor cells in the peritoneal cavity of mice

1975 • 3 citations

Murine leukemia growth inhibition or enhancement following immunization with tumor cells antigenically altered by drug treatment

1977 • 2 citations