Natural selection of tumor variants in the generation of “tumor escape” phenotypes

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 • 1,027 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

Regulation of Cutaneous Malignancy by γδ T Cells

2001 • 945 citations

Caspase activation: The induced-proximity model

1999 • 920 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Expression of cyclooxygenase-2 in human gastric carcinoma.

1997 • 829 citations

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1997 • 769 citations

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

2001 • 757 citations

Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles

2002 • 739 citations

Expression of cyclooxygenase-2 in human lung carcinoma.

1998 • 729 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

Effect of interleukin‐10 on dendritic cell maturation and function

1997 • 571 citations

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

2000 • 540 citations

Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells.

1998 • 524 citations

Loss of Functional Beta2-Microglobulin in Metastatic Melanomas From Five Patients Receiving Immunotherapy

1996 • 515 citations

Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production.

1998 • 498 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

2001 • 454 citations

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

2002 • 447 citations

Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-κB Activation in Hemopoietic Progenitor Cells

1998 • 440 citations

TGF-β Released by Apoptotic T Cells Contributes to an Immunosuppressive Milieu

2001 • 414 citations

Human lung carcinomas express Fas ligand.

1997 • 395 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

The onset and extent of genomic instability in sporadic colorectal tumor progression

1999 • 388 citations

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

2002 • 363 citations

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

2001 • 347 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein

1999 • 337 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Immune suppression and skin cancer development: regulation by NKT cells

2000 • 327 citations

Somatic Fas Mutations in Non-Hodgkin’s Lymphoma: Association With Extranodal Disease and Autoimmunity

1998 • 324 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

MHC antigens and tumor escape from immune surveillance

2001 • 300 citations

Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variantsin vivo

1996 • 274 citations

Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

2000 • 256 citations

T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function

1999 • 248 citations

Gene transfer of Fas ligand induces tumor regression in vivo

1997 • 247 citations

A New Mechanism of NK Cell Cytotoxicity Activation: The CD40–CD40 Ligand Interaction

1997 • 244 citations

Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer

1995 • 240 citations

Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules

1997 • 239 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 228 citations

Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40‐ligand) and TNF‐α, but strongly enhanced by interleukin‐10

1995 • 215 citations

How melanoma cells evade trail-induced apoptosis

2001 • 211 citations

beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma.

1998 • 193 citations

Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.

1997 • 187 citations

Downregulation of TAP1 in B Lymphocytes by Cellular and Epstein-Barr Virus–Encoded Interleukin-10

1997 • 186 citations

Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancer

1996 • 186 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 183 citations

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

1998 • 181 citations

Recognition of autologous dendritic cells by human NK cells

1999 • 177 citations

Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.

1989 • 164 citations

Immune selection after antigen-specific immunotherapy of melanoma

1999 • 162 citations

Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas

2002 • 145 citations

High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas

1998 • 143 citations

Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue

1998 • 141 citations

Alterations of Fas (Apo-1/CD95) Gene in Cutaneous Malignant Melanoma

1999 • 136 citations

Dendritic cells hold promise for immunotherapy

1997 • 135 citations

CD27-Mediated Activation of Murine NK Cells

2000 • 133 citations

Human melanoma cells do not express Fas (Apo-1/CD95) ligand.

1999 • 133 citations

Functional Dissociation Between Local and Systemic Immune Response During Anti-Melanoma Peptide Vaccination

1998 • 127 citations

Fas-Mediated Suicide of Tumor-Reactive T Cells Following Activation by Specific Tumor: Selective Rescue by Caspase Inhibition

1999 • 126 citations

High frequency of altered HLA class I phenotypes in invasive breast carcinomas

1996 • 120 citations

Suppression of class I human histocompatibility leukocyte antigen by c-myc is locus specific.

1989 • 112 citations

Clinical significance of the determination of angiogenic factors

1996 • 112 citations

Immunodominance and tumor escape

2002 • 110 citations

Natural killer cell lines kill autologous β₂-microglobulin-deficient melanoma cells: Implications for cancer immunotherapy

1997 • 109 citations

Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.

1997 • 92 citations

Expression of a Variant of CD28 on a Subpopulation of Human NK Cells: Implications for B7-Mediated Stimulation of NK Cells

1999 • 87 citations

Melan A/MART-1 immunoreactivity in formalin-fixed paraffin-embedded primary and metastatic melanoma: frequency and distribution

1998 • 84 citations

Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in anIn vitro melanoma model

1999 • 83 citations

Two mechanisms for tumor evasion of preexisting cytotoxic T-cell responses: lessons from recurrent tumors.

1999 • 76 citations

Alterations of Fas-pathway genes associated with nodal metastasis innon-small cell lung cancer

2002 • 73 citations

Altered MHC class I antigens in tumors

1997 • 66 citations

Molecular strategies to define HLA haplotype loss in microdissected tumor cells

2000 • 61 citations

Local inhibition of natural killer cell activity promotes the progressive growth of intraocular tumors.

1997 • 59 citations

Pillars Article: Regulation of Cutaneous Malignancy by γδ T Cells.

2018 • 58 citations

Locus-specific transcriptional control of HLA genes.

1992 • 55 citations

Human Leukocyte Antigen Class I Gene Mutations in Cervical Cancer

1999 • 55 citations

Locus-Specific Analysis of Human Leukocyte Antigen Class I Expression in Melanoma Cell Lines

1994 • 55 citations

Expression and function of the peptide transporters in escape variants of human renal cell carcinomas.

1997 • 39 citations

Systemic deficits in transporter for antigen presentation (TAP)‐1 or proteasome subunit LMP2 have little or no effect on tumor incidence

2001 • 33 citations

Assumptions of the tumor ‘escape’ hypothesis

2002 • 33 citations

Fas Ligand Expression on Islets as Well as Multiple Cell Lines Results in Accelerated Neutrophilic Rejection

1998 • 29 citations

Death Receptor Ligands in Tumors

2002 • 26 citations

Antitumor effect of allogenic fibroblasts engineered to express Fas ligand (FasL)

1998 • 25 citations

Oncogene and Cytokine Expression of Human Colorectal Tumors Responding to Immunotherapy

1997 • 15 citations