Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy

Mucins in cancer: protection and control of the cell surface

2003 • 1,716 citations

Pancreatic Intraepithelial Neoplasia

2001 • 1,100 citations

Expression cloning of a functional glycoprotein ligand for P-selectin

1993 • 734 citations

Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: Postoperative Adjuvant Chemoradiation Improves Survival

1997 • 600 citations

Structural organization and classification of the human mucin genes

2001 • 374 citations

Pancreaticoduodenectomy With or Without Extended Retroperitoneal Lymphadenectomy for Periampullary Adenocarcinoma

1999 • 365 citations

Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression.

1999 • 362 citations

Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland

2001 • 340 citations

Progression of Pancreatic Intraductal Neoplasias to Infiltrating Adenocarcinoma of the Pancreas

1998 • 307 citations

Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion

1997 • 306 citations

Two novel mucin genes down-regulated in colorectal cancer identified by differential display.

1999 • 297 citations

The Dichotomy in the Preinvasive Neoplasia to Invasive Carcinoma Sequence in the Pancreas: Differential Expression of MUC1 and MUC2 Supports the Existence of Two Separate Pathways of Carcinogenesis

2002 • 289 citations

The Epidermal Growth Factor Receptor Regulates Interaction of the Human DF3/MUC1 Carcinoma Antigen with c-Src and β-Catenin

2001 • 251 citations

Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance.

2001 • 248 citations

Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin

1999 • 248 citations

Human epithelial tumor antigen cDNA sequences

1990 • 242 citations

Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas

2002 • 241 citations

Interaction of Glycogen Synthase Kinase 3β with the DF3/MUC1 Carcinoma-Associated Antigen and β-Catenin

1998 • 238 citations

MUC4 Expression Increases Progressively in Pancreatic Intraepithelial Neoplasia

2002 • 238 citations

Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene

2002 • 233 citations

Inhibition of MUC4 Expression Suppresses Pancreatic Tumor Cell Growth and Metastasis

2004 • 231 citations

The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.

1996 • 221 citations

Oligosaccharides Expressed on MUC1 Produced by Pancreatic and Colon Tumor Cell Lines

1997 • 210 citations

MUC17, a Novel Membrane-Tethered Mucin

2002 • 202 citations

Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines

1994 • 171 citations

Dietary Meat, Dairy Products, Fat, and Cholesterol and Pancreatic Cancer Risk in a Prospective Study

2003 • 169 citations

Reversible Disruption of Cell-Matrix and Cell-Cell Interactions by Overexpression of Sialomucin Complex

1997 • 167 citations

Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells.

1999 • 137 citations

Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways

2002 • 137 citations

Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: Its relationship with the biological behavior of the tumor

1999 • 121 citations

Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development

1992 • 119 citations

MUC1 and MUC2 in pancreatic neoplasia: Figure 1

2004 • 118 citations

Tumor-suppressor gene products in cell contacts: the cad herin-APC-armadillo connection

1994 • 115 citations

Mucin gene expression in intraductal papillary‐mucinous pancreatic tumours and related lesions

2002 • 112 citations

Developmental Mucin Gene Expression in the Gastroduodenal Tract and Accessory Digestive Glands. II. Duodenum and Liver, Gallbladder, and Pancreas

2000 • 112 citations

Muc4/sialomucin complex, the intramembrane Er6B2 ligand, in cancer and epithelia: To protect and to survive

2002 • 110 citations

Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins

2000 • 109 citations

Aberrant Expression of MUC3 and MUC4 Membrane-Associated Mucins and Sialyl Lex Antigen in Pancreatic Intraepithelial Neoplasia

2003 • 105 citations

MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: Its close relationship with prognosis of the patients

1997 • 104 citations

Developmental expression of mucin genes in the human gastrointestinal system

1998 • 99 citations

Human MUC4 Mucin cDNA and Its Variants in Pancreatic Carcinoma

2000 • 76 citations

Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion

2000 • 70 citations

The oligomerization of a family of four genetically clustered human gastrointestinal mucins

1998 • 63 citations

Usefulness of novel tumour markers

1999 • 47 citations

Expression of Mucin Carbohydrate Antigens (T, Tn and Sialyl Tn) and MUC-1 Gene Product in Intraductal Papillary-Mucinous Neoplasm of the Pancreas

1996 • 38 citations

Aberrant expression of muc3 and muc4 membrane-associated mucins and sialyl lex antigen in pancreatic intraepithelial neoplasia

2003 • 38 citations

Are elevated levels of the tumour marker CA19-9 of any clinical significance? — An evaluation

1999 • 29 citations

Untitled

1999 • 18 citations

Purification and Characterization of a Human Pancreatic Adenocarcinoma Mucin

2002 • 17 citations